Evaluation and correction for optical scattering variations in laser speckle rheology of biological fluids.

Biological fluids fulfill key functionalities such as hydrating, protecting, and nourishing cells and tissues in various organ systems. They are capable of these versatile tasks owing to their distinct structural and viscoelastic properties. Characterizing the viscoelastic properties of bio-fluids i...

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Main Authors: Zeinab Hajjarian, Seemantini K Nadkarni
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3660338?pdf=render
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author Zeinab Hajjarian
Seemantini K Nadkarni
author_facet Zeinab Hajjarian
Seemantini K Nadkarni
author_sort Zeinab Hajjarian
collection DOAJ
description Biological fluids fulfill key functionalities such as hydrating, protecting, and nourishing cells and tissues in various organ systems. They are capable of these versatile tasks owing to their distinct structural and viscoelastic properties. Characterizing the viscoelastic properties of bio-fluids is of pivotal importance for monitoring the development of certain pathologies as well as engineering synthetic replacements. Laser Speckle Rheology (LSR) is a novel optical technology that enables mechanical evaluation of tissue. In LSR, a coherent laser beam illuminates the tissue and temporal speckle intensity fluctuations are analyzed to evaluate mechanical properties. The rate of temporal speckle fluctuations is, however, influenced by both optical and mechanical properties of tissue. Therefore, in this paper, we develop and validate an approach to estimate and compensate for the contributions of light scattering to speckle dynamics and demonstrate the capability of LSR for the accurate extraction of viscoelastic moduli in phantom samples and biological fluids of varying optical and mechanical properties.
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spelling doaj.art-f23239ef52f64ee4973be2a7e683992c2022-12-22T02:25:56ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0185e6501410.1371/journal.pone.0065014Evaluation and correction for optical scattering variations in laser speckle rheology of biological fluids.Zeinab HajjarianSeemantini K NadkarniBiological fluids fulfill key functionalities such as hydrating, protecting, and nourishing cells and tissues in various organ systems. They are capable of these versatile tasks owing to their distinct structural and viscoelastic properties. Characterizing the viscoelastic properties of bio-fluids is of pivotal importance for monitoring the development of certain pathologies as well as engineering synthetic replacements. Laser Speckle Rheology (LSR) is a novel optical technology that enables mechanical evaluation of tissue. In LSR, a coherent laser beam illuminates the tissue and temporal speckle intensity fluctuations are analyzed to evaluate mechanical properties. The rate of temporal speckle fluctuations is, however, influenced by both optical and mechanical properties of tissue. Therefore, in this paper, we develop and validate an approach to estimate and compensate for the contributions of light scattering to speckle dynamics and demonstrate the capability of LSR for the accurate extraction of viscoelastic moduli in phantom samples and biological fluids of varying optical and mechanical properties.http://europepmc.org/articles/PMC3660338?pdf=render
spellingShingle Zeinab Hajjarian
Seemantini K Nadkarni
Evaluation and correction for optical scattering variations in laser speckle rheology of biological fluids.
PLoS ONE
title Evaluation and correction for optical scattering variations in laser speckle rheology of biological fluids.
title_full Evaluation and correction for optical scattering variations in laser speckle rheology of biological fluids.
title_fullStr Evaluation and correction for optical scattering variations in laser speckle rheology of biological fluids.
title_full_unstemmed Evaluation and correction for optical scattering variations in laser speckle rheology of biological fluids.
title_short Evaluation and correction for optical scattering variations in laser speckle rheology of biological fluids.
title_sort evaluation and correction for optical scattering variations in laser speckle rheology of biological fluids
url http://europepmc.org/articles/PMC3660338?pdf=render
work_keys_str_mv AT zeinabhajjarian evaluationandcorrectionforopticalscatteringvariationsinlaserspecklerheologyofbiologicalfluids
AT seemantiniknadkarni evaluationandcorrectionforopticalscatteringvariationsinlaserspecklerheologyofbiologicalfluids