Investigating the relationship between interleukin‐6 serum levels and outcome in acute ischemic CVA
Abstract Introduction Interleukin‐6 (IL‐6) is among the inflammatory mediators exhibiting elevated levels in ischemic stroke (IS) patients. The present study set out to evaluate the relationship between serum levels of interleukin‐6 with long‐term and at‐hospital outcomes of acute ischemic stroke in...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-08-01
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| Series: | Brain and Behavior |
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| Online Access: | https://doi.org/10.1002/brb3.1668 |
| _version_ | 1818277647450374144 |
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| author | Arash Mosarrezaii Mohammad Reza Amiri‐Nikpour Hamid Reza Mehryar Babak Choobi Anzali Sarmad Nourooz‐Zadeh Shadi Babaei Hedieh Farrokhi |
| author_facet | Arash Mosarrezaii Mohammad Reza Amiri‐Nikpour Hamid Reza Mehryar Babak Choobi Anzali Sarmad Nourooz‐Zadeh Shadi Babaei Hedieh Farrokhi |
| author_sort | Arash Mosarrezaii |
| collection | DOAJ |
| description | Abstract Introduction Interleukin‐6 (IL‐6) is among the inflammatory mediators exhibiting elevated levels in ischemic stroke (IS) patients. The present study set out to evaluate the relationship between serum levels of interleukin‐6 with long‐term and at‐hospital outcomes of acute ischemic stroke in patients hospitalized at Imam Khomeini Hospital, Urmia, Iran, from 2017 to 2018. Method and materials This cross‐sectional descriptive study enrolled 29 and 31 acute stroke patients for long‐term and at‐hospital observation, respectively. Evaluation of stroke severity was performed using the National Institute of Health Stroke Scale (NIHSS) and the modified Rankin Scale (mRS) on days 1, 5, and 90. Serum IL‐6 level was measured via enzyme‐linked immunosorbent assay (ELISA) on days one and five. Results In the present cohort study, the following population were enrolled: for long‐term evaluation, 11 (38%) men and 18 (63%) women with a mean age of 64.5 ± 14.9 years, and for at‐hospital evaluation: 11 (37.5%) men and 20 (64.5%) with a mean age of 65.25 ± 14.37 years. A significant positive correlation was observed between IL‐6 levels with NIHSS and mRS scores of the patients from time of admission until the end of the follow‐up period (long‐term: p < .001; at‐hospital: 0.022). Conclusion The evidence from the present study suggests that IL‐6 contributes to the determination of the severity of ischemic strokes and may be useful in predicting prognosis. However, larger scale studies are required to further establish these finds. |
| first_indexed | 2024-12-12T23:04:52Z |
| format | Article |
| id | doaj.art-f2335b356ed4425ca6eace951333f291 |
| institution | Directory Open Access Journal |
| issn | 2162-3279 |
| language | English |
| last_indexed | 2024-12-12T23:04:52Z |
| publishDate | 2020-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | Brain and Behavior |
| spelling | doaj.art-f2335b356ed4425ca6eace951333f2912022-12-22T00:08:44ZengWileyBrain and Behavior2162-32792020-08-01108n/an/a10.1002/brb3.1668Investigating the relationship between interleukin‐6 serum levels and outcome in acute ischemic CVAArash Mosarrezaii0Mohammad Reza Amiri‐Nikpour1Hamid Reza Mehryar2Babak Choobi Anzali3Sarmad Nourooz‐Zadeh4Shadi Babaei5Hedieh Farrokhi6Department of Neurology Urmia University of Medical Sciences Urmia IranDepartment of Neurology Urmia University of Medical Sciences Urmia IranClinical Research Development Unit of Imam Khomeini Hospital Urmia University of Medical Sciences Urmia IranDepartment of Emergency Medicine Urmia University of Medical Sciences Urmia IranUrmia University of Medical Sciences Urmia IranUrmia University of Medical Sciences Urmia IranUrmia University of Medical Sciences Urmia IranAbstract Introduction Interleukin‐6 (IL‐6) is among the inflammatory mediators exhibiting elevated levels in ischemic stroke (IS) patients. The present study set out to evaluate the relationship between serum levels of interleukin‐6 with long‐term and at‐hospital outcomes of acute ischemic stroke in patients hospitalized at Imam Khomeini Hospital, Urmia, Iran, from 2017 to 2018. Method and materials This cross‐sectional descriptive study enrolled 29 and 31 acute stroke patients for long‐term and at‐hospital observation, respectively. Evaluation of stroke severity was performed using the National Institute of Health Stroke Scale (NIHSS) and the modified Rankin Scale (mRS) on days 1, 5, and 90. Serum IL‐6 level was measured via enzyme‐linked immunosorbent assay (ELISA) on days one and five. Results In the present cohort study, the following population were enrolled: for long‐term evaluation, 11 (38%) men and 18 (63%) women with a mean age of 64.5 ± 14.9 years, and for at‐hospital evaluation: 11 (37.5%) men and 20 (64.5%) with a mean age of 65.25 ± 14.37 years. A significant positive correlation was observed between IL‐6 levels with NIHSS and mRS scores of the patients from time of admission until the end of the follow‐up period (long‐term: p < .001; at‐hospital: 0.022). Conclusion The evidence from the present study suggests that IL‐6 contributes to the determination of the severity of ischemic strokes and may be useful in predicting prognosis. However, larger scale studies are required to further establish these finds.https://doi.org/10.1002/brb3.1668inflammatory factorsinterleukin‐6ischemic strokeserum levelstroke severity |
| spellingShingle | Arash Mosarrezaii Mohammad Reza Amiri‐Nikpour Hamid Reza Mehryar Babak Choobi Anzali Sarmad Nourooz‐Zadeh Shadi Babaei Hedieh Farrokhi Investigating the relationship between interleukin‐6 serum levels and outcome in acute ischemic CVA Brain and Behavior inflammatory factors interleukin‐6 ischemic stroke serum level stroke severity |
| title | Investigating the relationship between interleukin‐6 serum levels and outcome in acute ischemic CVA |
| title_full | Investigating the relationship between interleukin‐6 serum levels and outcome in acute ischemic CVA |
| title_fullStr | Investigating the relationship between interleukin‐6 serum levels and outcome in acute ischemic CVA |
| title_full_unstemmed | Investigating the relationship between interleukin‐6 serum levels and outcome in acute ischemic CVA |
| title_short | Investigating the relationship between interleukin‐6 serum levels and outcome in acute ischemic CVA |
| title_sort | investigating the relationship between interleukin 6 serum levels and outcome in acute ischemic cva |
| topic | inflammatory factors interleukin‐6 ischemic stroke serum level stroke severity |
| url | https://doi.org/10.1002/brb3.1668 |
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