Magneto-Mechanically Triggered Thick Films for Drug Delivery Micropumps
Given the demanding use of controlled drug delivery systems, our attention was focused on developing a magnetic film that can be triggered in the presence of a magnetic field for both drug delivery and the actuating mechanism in micropump biomedical microelectromechanical systems (BioMEMS). Magnetic...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Nanomaterials |
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| Online Access: | https://www.mdpi.com/2079-4991/12/20/3598 |
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| author | Georgiana Dolete Cristina Chircov Ludmila Motelica Denisa Ficai Ovidiu-Cristian Oprea Marin Gheorghe Anton Ficai Ecaterina Andronescu |
| author_facet | Georgiana Dolete Cristina Chircov Ludmila Motelica Denisa Ficai Ovidiu-Cristian Oprea Marin Gheorghe Anton Ficai Ecaterina Andronescu |
| author_sort | Georgiana Dolete |
| collection | DOAJ |
| description | Given the demanding use of controlled drug delivery systems, our attention was focused on developing a magnetic film that can be triggered in the presence of a magnetic field for both drug delivery and the actuating mechanism in micropump biomedical microelectromechanical systems (BioMEMS). Magnetic alginate films were fabricated in three steps: the co-precipitation of iron salts in an alkaline environment to obtain magnetite nanoparticles (Fe<sub>3</sub>O<sub>4</sub>), the mixing of the obtained nanoparticles with a sodium alginate solution containing glycerol as a plasticizer and folic acid as an active substance, and finally the casting of the final solution in a Petri dish followed by cross-linking with calcium chloride solution. Magnetite nanoparticles were incorporated in the alginate matrix because of the well-established biocompatibility of both materials, a property that would make the film convenient for implantable BioMEMS devices. The obtained film was analyzed in terms of its magnetic, structural, and morphological properties. To demonstrate the hypothesis that the magnetic field can be used to trigger drug release from the films, we studied the release profile in an aqueous medium (pH = 8) using a NdFeB magnet as a triggering factor. |
| first_indexed | 2024-03-09T19:40:57Z |
| format | Article |
| id | doaj.art-f234057708994eca975db1321d975184 |
| institution | Directory Open Access Journal |
| issn | 2079-4991 |
| language | English |
| last_indexed | 2024-03-09T19:40:57Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj.art-f234057708994eca975db1321d9751842023-11-24T01:39:56ZengMDPI AGNanomaterials2079-49912022-10-011220359810.3390/nano12203598Magneto-Mechanically Triggered Thick Films for Drug Delivery MicropumpsGeorgiana Dolete0Cristina Chircov1Ludmila Motelica2Denisa Ficai3Ovidiu-Cristian Oprea4Marin Gheorghe5Anton Ficai6Ecaterina Andronescu7Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Chemical Engineering and Biotechnologies, University Politehnica of Bucharest, Gh. Polizu 1-7, 011061 Bucharest, RomaniaDepartment of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Chemical Engineering and Biotechnologies, University Politehnica of Bucharest, Gh. Polizu 1-7, 011061 Bucharest, RomaniaDepartment of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Chemical Engineering and Biotechnologies, University Politehnica of Bucharest, Gh. Polizu 1-7, 011061 Bucharest, RomaniaNational Center for Micro and Nanomaterials, University Politehnica of Bucharest, Splaiul Independentei 313, 060042 Bucharest, RomaniaNational Center for Micro and Nanomaterials, University Politehnica of Bucharest, Splaiul Independentei 313, 060042 Bucharest, RomaniaSC NANOMEMS SRL, George Coșbuc 9, 505400 Râșnov, RomaniaDepartment of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Chemical Engineering and Biotechnologies, University Politehnica of Bucharest, Gh. Polizu 1-7, 011061 Bucharest, RomaniaDepartment of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Chemical Engineering and Biotechnologies, University Politehnica of Bucharest, Gh. Polizu 1-7, 011061 Bucharest, RomaniaGiven the demanding use of controlled drug delivery systems, our attention was focused on developing a magnetic film that can be triggered in the presence of a magnetic field for both drug delivery and the actuating mechanism in micropump biomedical microelectromechanical systems (BioMEMS). Magnetic alginate films were fabricated in three steps: the co-precipitation of iron salts in an alkaline environment to obtain magnetite nanoparticles (Fe<sub>3</sub>O<sub>4</sub>), the mixing of the obtained nanoparticles with a sodium alginate solution containing glycerol as a plasticizer and folic acid as an active substance, and finally the casting of the final solution in a Petri dish followed by cross-linking with calcium chloride solution. Magnetite nanoparticles were incorporated in the alginate matrix because of the well-established biocompatibility of both materials, a property that would make the film convenient for implantable BioMEMS devices. The obtained film was analyzed in terms of its magnetic, structural, and morphological properties. To demonstrate the hypothesis that the magnetic field can be used to trigger drug release from the films, we studied the release profile in an aqueous medium (pH = 8) using a NdFeB magnet as a triggering factor.https://www.mdpi.com/2079-4991/12/20/3598magnetic polymer thick filmsmagneto-mechanical triggeringdrug deliveryBioMEMs |
| spellingShingle | Georgiana Dolete Cristina Chircov Ludmila Motelica Denisa Ficai Ovidiu-Cristian Oprea Marin Gheorghe Anton Ficai Ecaterina Andronescu Magneto-Mechanically Triggered Thick Films for Drug Delivery Micropumps Nanomaterials magnetic polymer thick films magneto-mechanical triggering drug delivery BioMEMs |
| title | Magneto-Mechanically Triggered Thick Films for Drug Delivery Micropumps |
| title_full | Magneto-Mechanically Triggered Thick Films for Drug Delivery Micropumps |
| title_fullStr | Magneto-Mechanically Triggered Thick Films for Drug Delivery Micropumps |
| title_full_unstemmed | Magneto-Mechanically Triggered Thick Films for Drug Delivery Micropumps |
| title_short | Magneto-Mechanically Triggered Thick Films for Drug Delivery Micropumps |
| title_sort | magneto mechanically triggered thick films for drug delivery micropumps |
| topic | magnetic polymer thick films magneto-mechanical triggering drug delivery BioMEMs |
| url | https://www.mdpi.com/2079-4991/12/20/3598 |
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