Focus on Mitochondrial Respiratory Chain: Potential Therapeutic Target for Chronic Renal Failure
The function of the respiratory chain is closely associated with kidney function, and the dysfunction of the respiratory chain is a primary pathophysiological change in chronic kidney failure. The incidence of chronic kidney failure caused by defects in respiratory-chain-related genes has frequently...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-01-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/25/2/949 |
| _version_ | 1797339848738078720 |
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| author | Yi Wang Jing Yang Yu Zhang Jianhua Zhou |
| author_facet | Yi Wang Jing Yang Yu Zhang Jianhua Zhou |
| author_sort | Yi Wang |
| collection | DOAJ |
| description | The function of the respiratory chain is closely associated with kidney function, and the dysfunction of the respiratory chain is a primary pathophysiological change in chronic kidney failure. The incidence of chronic kidney failure caused by defects in respiratory-chain-related genes has frequently been overlooked. Correcting abnormal metabolic reprogramming, rescuing the “toxic respiratory chain”, and targeting the clearance of mitochondrial reactive oxygen species are potential therapies for treating chronic kidney failure. These treatments have shown promising results in slowing fibrosis and inflammation progression and improving kidney function in various animal models of chronic kidney failure and patients with chronic kidney disease (CKD). The mitochondrial respiratory chain is a key target worthy of attention in the treatment of chronic kidney failure. This review integrated research related to the mitochondrial respiratory chain and chronic kidney failure, primarily elucidating the pathological status of the mitochondrial respiratory chain in chronic kidney failure and potential therapeutic drugs. It provided new ideas for the treatment of kidney failure and promoted the development of drugs targeting the mitochondrial respiratory chain. |
| first_indexed | 2024-03-08T09:54:22Z |
| format | Article |
| id | doaj.art-f238369f10754d26aac9d8654d07b0e3 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-08T09:54:22Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-f238369f10754d26aac9d8654d07b0e32024-01-29T13:55:45ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672024-01-0125294910.3390/ijms25020949Focus on Mitochondrial Respiratory Chain: Potential Therapeutic Target for Chronic Renal FailureYi Wang0Jing Yang1Yu Zhang2Jianhua Zhou3Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan 430030, ChinaDepartment of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan 430030, ChinaDepartment of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan 430030, ChinaDepartment of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan 430030, ChinaThe function of the respiratory chain is closely associated with kidney function, and the dysfunction of the respiratory chain is a primary pathophysiological change in chronic kidney failure. The incidence of chronic kidney failure caused by defects in respiratory-chain-related genes has frequently been overlooked. Correcting abnormal metabolic reprogramming, rescuing the “toxic respiratory chain”, and targeting the clearance of mitochondrial reactive oxygen species are potential therapies for treating chronic kidney failure. These treatments have shown promising results in slowing fibrosis and inflammation progression and improving kidney function in various animal models of chronic kidney failure and patients with chronic kidney disease (CKD). The mitochondrial respiratory chain is a key target worthy of attention in the treatment of chronic kidney failure. This review integrated research related to the mitochondrial respiratory chain and chronic kidney failure, primarily elucidating the pathological status of the mitochondrial respiratory chain in chronic kidney failure and potential therapeutic drugs. It provided new ideas for the treatment of kidney failure and promoted the development of drugs targeting the mitochondrial respiratory chain.https://www.mdpi.com/1422-0067/25/2/949mitochondrial respiratory chainchronic renal failurepotential treatment strategies |
| spellingShingle | Yi Wang Jing Yang Yu Zhang Jianhua Zhou Focus on Mitochondrial Respiratory Chain: Potential Therapeutic Target for Chronic Renal Failure International Journal of Molecular Sciences mitochondrial respiratory chain chronic renal failure potential treatment strategies |
| title | Focus on Mitochondrial Respiratory Chain: Potential Therapeutic Target for Chronic Renal Failure |
| title_full | Focus on Mitochondrial Respiratory Chain: Potential Therapeutic Target for Chronic Renal Failure |
| title_fullStr | Focus on Mitochondrial Respiratory Chain: Potential Therapeutic Target for Chronic Renal Failure |
| title_full_unstemmed | Focus on Mitochondrial Respiratory Chain: Potential Therapeutic Target for Chronic Renal Failure |
| title_short | Focus on Mitochondrial Respiratory Chain: Potential Therapeutic Target for Chronic Renal Failure |
| title_sort | focus on mitochondrial respiratory chain potential therapeutic target for chronic renal failure |
| topic | mitochondrial respiratory chain chronic renal failure potential treatment strategies |
| url | https://www.mdpi.com/1422-0067/25/2/949 |
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