Lung Stereotactic Body Radiation Therapy (SBRT) dose gradient and PTV volume: a retrospective multi-center analysis
Abstract Background The treatment of lung lesions with stereotactic body radiation therapy calls for highly conformal dose, which is evaluated by a number of metrics. Lung stereotactic body radiation therapy clinical trials constrain a plans gradient index. The purpose of this work is to describe th...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2019-09-01
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| Series: | Radiation Oncology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13014-019-1334-9 |
| _version_ | 1818276685039009792 |
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| author | David Hoffman Irena Dragojević Jeremy Hoisak David Hoopes Ryan Manger |
| author_facet | David Hoffman Irena Dragojević Jeremy Hoisak David Hoopes Ryan Manger |
| author_sort | David Hoffman |
| collection | DOAJ |
| description | Abstract Background The treatment of lung lesions with stereotactic body radiation therapy calls for highly conformal dose, which is evaluated by a number of metrics. Lung stereotactic body radiation therapy clinical trials constrain a plans gradient index. The purpose of this work is to describe the dependence of clinically achievable dose gradient on planning target volume. Methods Three hundred seventy-four lung stereotactic body radiation therapy treatment plans were retrospectively reviewed and selected for this study. The relationship between R50% and planning target volume size was observed and compared against the RTOG 0915 and 0813 constraints noting minor and major deviations. Then a least squares regression was used to determine the coefficients for a power functional form of the dependence of gradient measure (GM) on planning target volume size. Results Of the 317 peripheral lung SBRT plans, 142 exhibited no deviation, 135 exhibited a minor deviation, and 40 exhibited a major deviation according to the RTOG 0915 dosimetric. conformality and dose fall-off constraints. A plot of gradient measure versus planning target volume size for peripheral lesions, excluding RTOG 0915 major deviations, is fit with an power function of GM = 0.564 V0.215. Conclusions Using the PTV size and GM relationship we have characterized, treatment plans with PTV < 85 cm3 can be evaluated subjectively to our previously plans, and given a percentile GM. This relationship and evaluation is useful for volumetric modulated arc therapy lung stereotactic body radiation therapy treatment planning and quality control. |
| first_indexed | 2024-12-12T22:49:34Z |
| format | Article |
| id | doaj.art-f2384b8b1b8f469c90d8486210dd48f8 |
| institution | Directory Open Access Journal |
| issn | 1748-717X |
| language | English |
| last_indexed | 2024-12-12T22:49:34Z |
| publishDate | 2019-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Radiation Oncology |
| spelling | doaj.art-f2384b8b1b8f469c90d8486210dd48f82022-12-22T00:09:07ZengBMCRadiation Oncology1748-717X2019-09-011411710.1186/s13014-019-1334-9Lung Stereotactic Body Radiation Therapy (SBRT) dose gradient and PTV volume: a retrospective multi-center analysisDavid Hoffman0Irena Dragojević1Jeremy Hoisak2David Hoopes3Ryan Manger4UC San Diego Radiation Medicine and Applied SciencesUC San Diego Radiation Medicine and Applied SciencesUC San Diego Radiation Medicine and Applied SciencesUC San Diego Radiation Medicine and Applied SciencesUC San Diego Radiation Medicine and Applied SciencesAbstract Background The treatment of lung lesions with stereotactic body radiation therapy calls for highly conformal dose, which is evaluated by a number of metrics. Lung stereotactic body radiation therapy clinical trials constrain a plans gradient index. The purpose of this work is to describe the dependence of clinically achievable dose gradient on planning target volume. Methods Three hundred seventy-four lung stereotactic body radiation therapy treatment plans were retrospectively reviewed and selected for this study. The relationship between R50% and planning target volume size was observed and compared against the RTOG 0915 and 0813 constraints noting minor and major deviations. Then a least squares regression was used to determine the coefficients for a power functional form of the dependence of gradient measure (GM) on planning target volume size. Results Of the 317 peripheral lung SBRT plans, 142 exhibited no deviation, 135 exhibited a minor deviation, and 40 exhibited a major deviation according to the RTOG 0915 dosimetric. conformality and dose fall-off constraints. A plot of gradient measure versus planning target volume size for peripheral lesions, excluding RTOG 0915 major deviations, is fit with an power function of GM = 0.564 V0.215. Conclusions Using the PTV size and GM relationship we have characterized, treatment plans with PTV < 85 cm3 can be evaluated subjectively to our previously plans, and given a percentile GM. This relationship and evaluation is useful for volumetric modulated arc therapy lung stereotactic body radiation therapy treatment planning and quality control.http://link.springer.com/article/10.1186/s13014-019-1334-9SBRTLung cancerRadiotherapyGradient indexGradient measureRetrospective |
| spellingShingle | David Hoffman Irena Dragojević Jeremy Hoisak David Hoopes Ryan Manger Lung Stereotactic Body Radiation Therapy (SBRT) dose gradient and PTV volume: a retrospective multi-center analysis Radiation Oncology SBRT Lung cancer Radiotherapy Gradient index Gradient measure Retrospective |
| title | Lung Stereotactic Body Radiation Therapy (SBRT) dose gradient and PTV volume: a retrospective multi-center analysis |
| title_full | Lung Stereotactic Body Radiation Therapy (SBRT) dose gradient and PTV volume: a retrospective multi-center analysis |
| title_fullStr | Lung Stereotactic Body Radiation Therapy (SBRT) dose gradient and PTV volume: a retrospective multi-center analysis |
| title_full_unstemmed | Lung Stereotactic Body Radiation Therapy (SBRT) dose gradient and PTV volume: a retrospective multi-center analysis |
| title_short | Lung Stereotactic Body Radiation Therapy (SBRT) dose gradient and PTV volume: a retrospective multi-center analysis |
| title_sort | lung stereotactic body radiation therapy sbrt dose gradient and ptv volume a retrospective multi center analysis |
| topic | SBRT Lung cancer Radiotherapy Gradient index Gradient measure Retrospective |
| url | http://link.springer.com/article/10.1186/s13014-019-1334-9 |
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