Activation of STING Based on Its Structural Features
The cGAS-cGAMP-STING pathway is an important innate immune signaling cascade responsible for the sensing of abnormal cytosolic double-stranded DNA (dsDNA), which is a hallmark of infection or cancers. Recently, tremendous progress has been made in the understanding of the STING activation mechanism...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-07-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.808607/full |
| _version_ | 1811292697071190016 |
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| author | Behzad Hussain Yufeng Xie Uzma Jabeen Defen Lu Bo Yang Bo Yang Changxin Wu Guijun Shang Guijun Shang |
| author_facet | Behzad Hussain Yufeng Xie Uzma Jabeen Defen Lu Bo Yang Bo Yang Changxin Wu Guijun Shang Guijun Shang |
| author_sort | Behzad Hussain |
| collection | DOAJ |
| description | The cGAS-cGAMP-STING pathway is an important innate immune signaling cascade responsible for the sensing of abnormal cytosolic double-stranded DNA (dsDNA), which is a hallmark of infection or cancers. Recently, tremendous progress has been made in the understanding of the STING activation mechanism from various aspects. In this review, the molecular mechanism of activation of STING protein based on its structural features is briefly discussed. The underlying molecular mechanism of STING activation will enable us to develop novel therapeutics to treat STING-associated diseases and understand how STING has evolved to eliminate infection and maintain immune homeostasis in innate immunity. |
| first_indexed | 2024-04-13T04:49:18Z |
| format | Article |
| id | doaj.art-f2389d11b36c492985c5ef9ac1530ad4 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-13T04:49:18Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-f2389d11b36c492985c5ef9ac1530ad42022-12-22T03:01:44ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-07-011310.3389/fimmu.2022.808607808607Activation of STING Based on Its Structural FeaturesBehzad Hussain0Yufeng Xie1Uzma Jabeen2Defen Lu3Bo Yang4Bo Yang5Changxin Wu6Guijun Shang7Guijun Shang8The Key Laboratory of Medical Molecular Cell Biology of Shanxi Province, The Institutes of Biomedical Sciences, Shanxi University, Taiyuan, ChinaDepartment of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing, ChinaInstitute of Microbiology, University of Veterinary and Animal Sciences, Lahore, PakistanCAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, ChinaShanxi Provincial Key Laboratory of Protein Structure Determination, Shanxi Academy of Advanced Research and Innovation, Taiyuan, ChinaShanxi Provincial Key Laboratory for Major Infectious Disease Response, Shanxi Academy of Advanced Research and Innovation, Taiyuan, ChinaThe Key Laboratory of Medical Molecular Cell Biology of Shanxi Province, The Institutes of Biomedical Sciences, Shanxi University, Taiyuan, ChinaShanxi Provincial Key Laboratory of Protein Structure Determination, Shanxi Academy of Advanced Research and Innovation, Taiyuan, ChinaShanxi Provincial Key Laboratory for Major Infectious Disease Response, Shanxi Academy of Advanced Research and Innovation, Taiyuan, ChinaThe cGAS-cGAMP-STING pathway is an important innate immune signaling cascade responsible for the sensing of abnormal cytosolic double-stranded DNA (dsDNA), which is a hallmark of infection or cancers. Recently, tremendous progress has been made in the understanding of the STING activation mechanism from various aspects. In this review, the molecular mechanism of activation of STING protein based on its structural features is briefly discussed. The underlying molecular mechanism of STING activation will enable us to develop novel therapeutics to treat STING-associated diseases and understand how STING has evolved to eliminate infection and maintain immune homeostasis in innate immunity.https://www.frontiersin.org/articles/10.3389/fimmu.2022.808607/fullstimulator of interferon genescyclic GMP-AMPcyclic GMP-AMP Synthase (cGAS)innate immunitycyclic dinucleotide |
| spellingShingle | Behzad Hussain Yufeng Xie Uzma Jabeen Defen Lu Bo Yang Bo Yang Changxin Wu Guijun Shang Guijun Shang Activation of STING Based on Its Structural Features Frontiers in Immunology stimulator of interferon genes cyclic GMP-AMP cyclic GMP-AMP Synthase (cGAS) innate immunity cyclic dinucleotide |
| title | Activation of STING Based on Its Structural Features |
| title_full | Activation of STING Based on Its Structural Features |
| title_fullStr | Activation of STING Based on Its Structural Features |
| title_full_unstemmed | Activation of STING Based on Its Structural Features |
| title_short | Activation of STING Based on Its Structural Features |
| title_sort | activation of sting based on its structural features |
| topic | stimulator of interferon genes cyclic GMP-AMP cyclic GMP-AMP Synthase (cGAS) innate immunity cyclic dinucleotide |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.808607/full |
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