Aspirin Exerts Synergistic Effect with Anti-Fas Stimulation against Colorectal Cancer Stem Cells In Vitro
Cancer cells, especially cancer stem cells (CSCs), are known for their therapeutic resistance and ability to induce a cancer relapse even many years after successful treatment. The quest for a novel protocol utilizing some commonly used non-oncologic drugs that would improve patients outcomes seems...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-10-01
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| Series: | Applied Sciences |
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| Online Access: | https://www.mdpi.com/2076-3417/11/21/10009 |
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| author | Magdalena Szaryńska Agata Olejniczak-Kęder Adrian Zubrzycki Anna Wardowska Zbigniew Kmieć |
| author_facet | Magdalena Szaryńska Agata Olejniczak-Kęder Adrian Zubrzycki Anna Wardowska Zbigniew Kmieć |
| author_sort | Magdalena Szaryńska |
| collection | DOAJ |
| description | Cancer cells, especially cancer stem cells (CSCs), are known for their therapeutic resistance and ability to induce a cancer relapse even many years after successful treatment. The quest for a novel protocol utilizing some commonly used non-oncologic drugs that would improve patients outcomes seems to be the right solution. Aspirin (ASA) is one of such eminent drugs. Our study demonstrated that ASA may exert synergistic effect with the anti-Fas antibody on CSCs of colorectal cancer cell lines. We found that such compound treatment inhibited the pro-cancerous effect of anti-Fas stimulation and decreased spherogenicity, survival and CD133-positive cells’ count. Additionally, ASA with anti-Fas antibody may have a positive impact on dendritic cells’ functions. Our innovative study explored simultaneous usage of two biologically active compounds which haven’t been considered in such combination to assess their significance in colorectal cancer cell biology. |
| first_indexed | 2024-03-10T06:07:32Z |
| format | Article |
| id | doaj.art-f238bb1d04a6494ca9f44fcad3067636 |
| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-03-10T06:07:32Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj.art-f238bb1d04a6494ca9f44fcad30676362023-11-22T20:26:25ZengMDPI AGApplied Sciences2076-34172021-10-0111211000910.3390/app112110009Aspirin Exerts Synergistic Effect with Anti-Fas Stimulation against Colorectal Cancer Stem Cells In VitroMagdalena Szaryńska0Agata Olejniczak-Kęder1Adrian Zubrzycki2Anna Wardowska3Zbigniew Kmieć4Department of Histology, Medical University of Gdansk, 80-210 Gdansk, PolandDepartment of Histology, Medical University of Gdansk, 80-210 Gdansk, PolandDepartment of Histology, Medical University of Gdansk, 80-210 Gdansk, PolandDepartment of Physiopathology, Medical University of Gdansk, 80-210 Gdansk, PolandDepartment of Histology, Medical University of Gdansk, 80-210 Gdansk, PolandCancer cells, especially cancer stem cells (CSCs), are known for their therapeutic resistance and ability to induce a cancer relapse even many years after successful treatment. The quest for a novel protocol utilizing some commonly used non-oncologic drugs that would improve patients outcomes seems to be the right solution. Aspirin (ASA) is one of such eminent drugs. Our study demonstrated that ASA may exert synergistic effect with the anti-Fas antibody on CSCs of colorectal cancer cell lines. We found that such compound treatment inhibited the pro-cancerous effect of anti-Fas stimulation and decreased spherogenicity, survival and CD133-positive cells’ count. Additionally, ASA with anti-Fas antibody may have a positive impact on dendritic cells’ functions. Our innovative study explored simultaneous usage of two biologically active compounds which haven’t been considered in such combination to assess their significance in colorectal cancer cell biology.https://www.mdpi.com/2076-3417/11/21/10009cancer stem cellscolorectal canceranti-Fasaspirindendritic cells |
| spellingShingle | Magdalena Szaryńska Agata Olejniczak-Kęder Adrian Zubrzycki Anna Wardowska Zbigniew Kmieć Aspirin Exerts Synergistic Effect with Anti-Fas Stimulation against Colorectal Cancer Stem Cells In Vitro Applied Sciences cancer stem cells colorectal cancer anti-Fas aspirin dendritic cells |
| title | Aspirin Exerts Synergistic Effect with Anti-Fas Stimulation against Colorectal Cancer Stem Cells In Vitro |
| title_full | Aspirin Exerts Synergistic Effect with Anti-Fas Stimulation against Colorectal Cancer Stem Cells In Vitro |
| title_fullStr | Aspirin Exerts Synergistic Effect with Anti-Fas Stimulation against Colorectal Cancer Stem Cells In Vitro |
| title_full_unstemmed | Aspirin Exerts Synergistic Effect with Anti-Fas Stimulation against Colorectal Cancer Stem Cells In Vitro |
| title_short | Aspirin Exerts Synergistic Effect with Anti-Fas Stimulation against Colorectal Cancer Stem Cells In Vitro |
| title_sort | aspirin exerts synergistic effect with anti fas stimulation against colorectal cancer stem cells in vitro |
| topic | cancer stem cells colorectal cancer anti-Fas aspirin dendritic cells |
| url | https://www.mdpi.com/2076-3417/11/21/10009 |
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