Recurrent deletions of the X chromosome linked CNV64, CNV67, and CNV69 shows geographic differences across China and no association with idiopathic infertility in men.
A recent study found that three recurrent deletions of X chromosome linked copy number variations (CNVs), CNV64, CNV67 and CNV69 were associated with idiopathic male infertility in Spanish and Italian populations, especially CNV67 resembling the azoospermia factor deletions. That merits further inve...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2017-01-01
|
| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5608304?pdf=render |
| _version_ | 1819176892261990400 |
|---|---|
| author | Xiulan Ma Martin Kuete Xiuli Gu Hui Zhou Chengliang Xiong Honggang Li |
| author_facet | Xiulan Ma Martin Kuete Xiuli Gu Hui Zhou Chengliang Xiong Honggang Li |
| author_sort | Xiulan Ma |
| collection | DOAJ |
| description | A recent study found that three recurrent deletions of X chromosome linked copy number variations (CNVs), CNV64, CNV67 and CNV69 were associated with idiopathic male infertility in Spanish and Italian populations, especially CNV67 resembling the azoospermia factor deletions. That merits further investigations among different populations. This study was conducted to examine the prevalence of the three CNVs deletions and their associations with idiopathic male infertility in Chinese Han population. The present study included a large population of 1550 Chinese Han subjects recruited between 2014 and 2016. In total, 714 infertile participants were diagnosed as idiopathic infertility with different conditions (288 with non-obstructive azoospermia, 210 oligozoospermia and 216 asthenospermia) and 836 fertile participants (vasectomized men). The fertile participants were recruited from the representative areas: the north (Hebei and Shanxi), center (Hubei and Jiangsu), and south (Guangdong) of China. All patients were recruited from Hubei province. A multiplex PCR system was established to screen the deletion of the three CNVs, and deletion was confirmed by general PCR. Similar rates of these deletions were observed in infertile men and fertile participants (Hubei), and among the different conditions of infertility. Moreover, CNV64 and CNV67 map distribution geographically differed across China. The three CNVs in fertile groups of other regions were similar, except for Guangdong. No association between the three CNVs deletions and idiopathic male infertility was observed. CNV67 is rare in central China, albeit large sample size study for confirmation is warranted. It seems that the association between these CNVs deletions and idiopathic male infertility is ethnic dependent. There is still need to screen the CNVs deletions in other ethnicities. We suggested to consider the stratification patterns and geographic differences when prescribing CNVs deletions screening as a test in male infertility. |
| first_indexed | 2024-12-22T21:17:59Z |
| format | Article |
| id | doaj.art-f239126f8242457ab8e03f5476b32745 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-22T21:17:59Z |
| publishDate | 2017-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-f239126f8242457ab8e03f5476b327452022-12-21T18:12:19ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01129e018508410.1371/journal.pone.0185084Recurrent deletions of the X chromosome linked CNV64, CNV67, and CNV69 shows geographic differences across China and no association with idiopathic infertility in men.Xiulan MaMartin KueteXiuli GuHui ZhouChengliang XiongHonggang LiA recent study found that three recurrent deletions of X chromosome linked copy number variations (CNVs), CNV64, CNV67 and CNV69 were associated with idiopathic male infertility in Spanish and Italian populations, especially CNV67 resembling the azoospermia factor deletions. That merits further investigations among different populations. This study was conducted to examine the prevalence of the three CNVs deletions and their associations with idiopathic male infertility in Chinese Han population. The present study included a large population of 1550 Chinese Han subjects recruited between 2014 and 2016. In total, 714 infertile participants were diagnosed as idiopathic infertility with different conditions (288 with non-obstructive azoospermia, 210 oligozoospermia and 216 asthenospermia) and 836 fertile participants (vasectomized men). The fertile participants were recruited from the representative areas: the north (Hebei and Shanxi), center (Hubei and Jiangsu), and south (Guangdong) of China. All patients were recruited from Hubei province. A multiplex PCR system was established to screen the deletion of the three CNVs, and deletion was confirmed by general PCR. Similar rates of these deletions were observed in infertile men and fertile participants (Hubei), and among the different conditions of infertility. Moreover, CNV64 and CNV67 map distribution geographically differed across China. The three CNVs in fertile groups of other regions were similar, except for Guangdong. No association between the three CNVs deletions and idiopathic male infertility was observed. CNV67 is rare in central China, albeit large sample size study for confirmation is warranted. It seems that the association between these CNVs deletions and idiopathic male infertility is ethnic dependent. There is still need to screen the CNVs deletions in other ethnicities. We suggested to consider the stratification patterns and geographic differences when prescribing CNVs deletions screening as a test in male infertility.http://europepmc.org/articles/PMC5608304?pdf=render |
| spellingShingle | Xiulan Ma Martin Kuete Xiuli Gu Hui Zhou Chengliang Xiong Honggang Li Recurrent deletions of the X chromosome linked CNV64, CNV67, and CNV69 shows geographic differences across China and no association with idiopathic infertility in men. PLoS ONE |
| title | Recurrent deletions of the X chromosome linked CNV64, CNV67, and CNV69 shows geographic differences across China and no association with idiopathic infertility in men. |
| title_full | Recurrent deletions of the X chromosome linked CNV64, CNV67, and CNV69 shows geographic differences across China and no association with idiopathic infertility in men. |
| title_fullStr | Recurrent deletions of the X chromosome linked CNV64, CNV67, and CNV69 shows geographic differences across China and no association with idiopathic infertility in men. |
| title_full_unstemmed | Recurrent deletions of the X chromosome linked CNV64, CNV67, and CNV69 shows geographic differences across China and no association with idiopathic infertility in men. |
| title_short | Recurrent deletions of the X chromosome linked CNV64, CNV67, and CNV69 shows geographic differences across China and no association with idiopathic infertility in men. |
| title_sort | recurrent deletions of the x chromosome linked cnv64 cnv67 and cnv69 shows geographic differences across china and no association with idiopathic infertility in men |
| url | http://europepmc.org/articles/PMC5608304?pdf=render |
| work_keys_str_mv | AT xiulanma recurrentdeletionsofthexchromosomelinkedcnv64cnv67andcnv69showsgeographicdifferencesacrosschinaandnoassociationwithidiopathicinfertilityinmen AT martinkuete recurrentdeletionsofthexchromosomelinkedcnv64cnv67andcnv69showsgeographicdifferencesacrosschinaandnoassociationwithidiopathicinfertilityinmen AT xiuligu recurrentdeletionsofthexchromosomelinkedcnv64cnv67andcnv69showsgeographicdifferencesacrosschinaandnoassociationwithidiopathicinfertilityinmen AT huizhou recurrentdeletionsofthexchromosomelinkedcnv64cnv67andcnv69showsgeographicdifferencesacrosschinaandnoassociationwithidiopathicinfertilityinmen AT chengliangxiong recurrentdeletionsofthexchromosomelinkedcnv64cnv67andcnv69showsgeographicdifferencesacrosschinaandnoassociationwithidiopathicinfertilityinmen AT honggangli recurrentdeletionsofthexchromosomelinkedcnv64cnv67andcnv69showsgeographicdifferencesacrosschinaandnoassociationwithidiopathicinfertilityinmen |