Cortical Endplate Bone Density Measured by Novel Phantomless Quantitative Computed Tomography May Predict Cage Subsidence more Conveniently and Accurately
Objective Previous studies have shown that bone mineral density (BMD) is a predictor of cage subsidence. Phantom‐less quantitative computed tomography (PL‐QCT) can measure volumetric bone mineral density (vBMD) of lumbar trabecular and cortical bone. The study of endplate vBMD (EP‐vBMD) is important...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-12-01
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| Series: | Orthopaedic Surgery |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/os.13897 |
| _version_ | 1797405540692787200 |
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| author | Mingyuan Di Yuanzhi Weng Guohua Wang Hanming Bian Huan Qi Hongjin Wu Chao Chen Yiming Dou Zhi Wang Xinlong Ma Baoshan Xu Shan Zhu Weijia William Lu Qiang Yang |
| author_facet | Mingyuan Di Yuanzhi Weng Guohua Wang Hanming Bian Huan Qi Hongjin Wu Chao Chen Yiming Dou Zhi Wang Xinlong Ma Baoshan Xu Shan Zhu Weijia William Lu Qiang Yang |
| author_sort | Mingyuan Di |
| collection | DOAJ |
| description | Objective Previous studies have shown that bone mineral density (BMD) is a predictor of cage subsidence. Phantom‐less quantitative computed tomography (PL‐QCT) can measure volumetric bone mineral density (vBMD) of lumbar trabecular and cortical bone. The study of endplate vBMD (EP‐vBMD) is important in predicting cage settlement after extreme lateral interbody fusion (XLIF). This study aimed to determine the risk factors for postoperative cage subsidence after XLIF, particularly focusing on the relationship between vBMD measured by automatic PL‐QCT and cage subsidence. Methods Patients who underwent XLIF surgery from January 2018 to October 2020 with a minimum of 6 months of follow‐up were retrospectively included. Cage subsidence was defined as >2 mm cage sinking on the adjacent endplate in follow‐up imaging evaluation. Outcome measures were localized vBMDs included EP‐vBMDs with different region of interest (ROI) heights measured by PL‐QCT based on a customized muscle‐fat algorithm. Shapiro–Wilk test, one‐way ANOVA, Mann–Whitney test, Fisher exact test, univariable and multivariable logistic regression and receiver operating characteristic (ROC) curve analysis were executed in this study. Results One hundred and thirteen levels of 78 patients were included in the analysis. The mean age was 65 ± 7.9 years for 11 males and 67 females. Cage subsidence occurred on 45 (39.8%) surgical levels. There was no significant difference in demographics, fused levels, or preoperative radiographic parameters. 1.25‐mm EP‐vBMD (0.991 [0.985,0.997], p = 0.004) and P‐TB‐vBMD (cage‐positioned trabecular volumetric bone mineral density) (0.988 [0.977–0.999], p = 0.026) were cage‐subsidence relevant according to univariate analysis. Low 1.25‐mm EP‐vBMD (0.992 [0.985, 0.999], p = 0.029) was an independent risk factor according to multifactorial analysis. Conclusion Preoperative low EP‐vBMD was an independent risk factor for postoperative cage subsidence after XLIF. EP‐vBMD measured by most cortex‐occupied ROI may be the optimal vBMD parameter for cage subsidence prediction. |
| first_indexed | 2024-03-09T03:12:26Z |
| format | Article |
| id | doaj.art-f239591fe2e14e1faeb94c00be379ce4 |
| institution | Directory Open Access Journal |
| issn | 1757-7853 1757-7861 |
| language | English |
| last_indexed | 2024-03-09T03:12:26Z |
| publishDate | 2023-12-01 |
| publisher | Wiley |
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| series | Orthopaedic Surgery |
| spelling | doaj.art-f239591fe2e14e1faeb94c00be379ce42023-12-04T02:35:48ZengWileyOrthopaedic Surgery1757-78531757-78612023-12-0115123126313510.1111/os.13897Cortical Endplate Bone Density Measured by Novel Phantomless Quantitative Computed Tomography May Predict Cage Subsidence more Conveniently and AccuratelyMingyuan Di0Yuanzhi Weng1Guohua Wang2Hanming Bian3Huan Qi4Hongjin Wu5Chao Chen6Yiming Dou7Zhi Wang8Xinlong Ma9Baoshan Xu10Shan Zhu11Weijia William Lu12Qiang Yang13Graduate School Tianjin Medical University Tianjin ChinaDepartment of Orthopaedics and Traumatology Li Ka Shing Faculty of Medicine, The University of Hong Kong Pokfulam ChinaGraduate School Tianjin Medical University Tianjin ChinaGraduate School Tianjin Medical University Tianjin ChinaDepartment of Orthopaedics and Traumatology Li Ka Shing Faculty of Medicine, The University of Hong Kong Pokfulam ChinaGraduate School Tianjin Medical University Tianjin ChinaDepartment of Spine Surgery Tianjin Hospital, Tianjin University Tianjin ChinaDepartment of Spine Surgery Tianjin Hospital, Tianjin University Tianjin ChinaTianjin Hospital of Tianjin University Tianjin ChinaDepartment of Spine Surgery Tianjin Hospital, Tianjin University Tianjin ChinaDepartment of Spine Surgery Tianjin Hospital, Tianjin University Tianjin ChinaTianjin Hospital of Tianjin University Tianjin ChinaDepartment of Orthopaedics and Traumatology Li Ka Shing Faculty of Medicine, The University of Hong Kong Pokfulam ChinaDepartment of Spine Surgery Tianjin Hospital, Tianjin University Tianjin ChinaObjective Previous studies have shown that bone mineral density (BMD) is a predictor of cage subsidence. Phantom‐less quantitative computed tomography (PL‐QCT) can measure volumetric bone mineral density (vBMD) of lumbar trabecular and cortical bone. The study of endplate vBMD (EP‐vBMD) is important in predicting cage settlement after extreme lateral interbody fusion (XLIF). This study aimed to determine the risk factors for postoperative cage subsidence after XLIF, particularly focusing on the relationship between vBMD measured by automatic PL‐QCT and cage subsidence. Methods Patients who underwent XLIF surgery from January 2018 to October 2020 with a minimum of 6 months of follow‐up were retrospectively included. Cage subsidence was defined as >2 mm cage sinking on the adjacent endplate in follow‐up imaging evaluation. Outcome measures were localized vBMDs included EP‐vBMDs with different region of interest (ROI) heights measured by PL‐QCT based on a customized muscle‐fat algorithm. Shapiro–Wilk test, one‐way ANOVA, Mann–Whitney test, Fisher exact test, univariable and multivariable logistic regression and receiver operating characteristic (ROC) curve analysis were executed in this study. Results One hundred and thirteen levels of 78 patients were included in the analysis. The mean age was 65 ± 7.9 years for 11 males and 67 females. Cage subsidence occurred on 45 (39.8%) surgical levels. There was no significant difference in demographics, fused levels, or preoperative radiographic parameters. 1.25‐mm EP‐vBMD (0.991 [0.985,0.997], p = 0.004) and P‐TB‐vBMD (cage‐positioned trabecular volumetric bone mineral density) (0.988 [0.977–0.999], p = 0.026) were cage‐subsidence relevant according to univariate analysis. Low 1.25‐mm EP‐vBMD (0.992 [0.985, 0.999], p = 0.029) was an independent risk factor according to multifactorial analysis. Conclusion Preoperative low EP‐vBMD was an independent risk factor for postoperative cage subsidence after XLIF. EP‐vBMD measured by most cortex‐occupied ROI may be the optimal vBMD parameter for cage subsidence prediction.https://doi.org/10.1111/os.13897Cage subsidenceEndplateExtreme lateral interbody fusionPhantom‐less quantitative computed tomographyVolumetric bone mineral density |
| spellingShingle | Mingyuan Di Yuanzhi Weng Guohua Wang Hanming Bian Huan Qi Hongjin Wu Chao Chen Yiming Dou Zhi Wang Xinlong Ma Baoshan Xu Shan Zhu Weijia William Lu Qiang Yang Cortical Endplate Bone Density Measured by Novel Phantomless Quantitative Computed Tomography May Predict Cage Subsidence more Conveniently and Accurately Orthopaedic Surgery Cage subsidence Endplate Extreme lateral interbody fusion Phantom‐less quantitative computed tomography Volumetric bone mineral density |
| title | Cortical Endplate Bone Density Measured by Novel Phantomless Quantitative Computed Tomography May Predict Cage Subsidence more Conveniently and Accurately |
| title_full | Cortical Endplate Bone Density Measured by Novel Phantomless Quantitative Computed Tomography May Predict Cage Subsidence more Conveniently and Accurately |
| title_fullStr | Cortical Endplate Bone Density Measured by Novel Phantomless Quantitative Computed Tomography May Predict Cage Subsidence more Conveniently and Accurately |
| title_full_unstemmed | Cortical Endplate Bone Density Measured by Novel Phantomless Quantitative Computed Tomography May Predict Cage Subsidence more Conveniently and Accurately |
| title_short | Cortical Endplate Bone Density Measured by Novel Phantomless Quantitative Computed Tomography May Predict Cage Subsidence more Conveniently and Accurately |
| title_sort | cortical endplate bone density measured by novel phantomless quantitative computed tomography may predict cage subsidence more conveniently and accurately |
| topic | Cage subsidence Endplate Extreme lateral interbody fusion Phantom‐less quantitative computed tomography Volumetric bone mineral density |
| url | https://doi.org/10.1111/os.13897 |
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