MORPHOLOGICAL, IMMUNOHISTOCHEMICAL AND SPECTRAL CHARACTERISTICS OF DYSPLASIA, PREINVASIVE AND INVASIVE FORMS OF LUNG CANCER
An analysis of modern methods of diagnostics such as morphological, immunohistochemical and spectral, which included the bronchoscopy and spectrometry by using reflectance and autofluorescent regime, was made. The data involved the results of prospective follow-up study of 167 patients (620 biopsies...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | Russian |
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Pavlov First Saint Petersburg State Medical University
2018-01-01
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| Series: | Вестник хирургии имени И.И. Грекова |
| Subjects: | |
| Online Access: | https://www.vestnik-grekova.ru/jour/article/view/649 |
| _version_ | 1797877693200465920 |
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| author | A. I. Arseniev A. A. Barchuk E. A. Zhelbunova D. E. Matsko A. S. Barchuk E. V. Levchenko K. E. Gagua K. A. Kostitsyn S. A. Tarkov A. O. Nefyodov |
| author_facet | A. I. Arseniev A. A. Barchuk E. A. Zhelbunova D. E. Matsko A. S. Barchuk E. V. Levchenko K. E. Gagua K. A. Kostitsyn S. A. Tarkov A. O. Nefyodov |
| author_sort | A. I. Arseniev |
| collection | DOAJ |
| description | An analysis of modern methods of diagnostics such as morphological, immunohistochemical and spectral, which included the bronchoscopy and spectrometry by using reflectance and autofluorescent regime, was made. The data involved the results of prospective follow-up study of 167 patients (620 biopsies). An obligatory spectrometry of suspicious area was carried out before the forceps biopsy. The microslides, which met the requirements of criteria of one of the carcinogen steps (n=201), were subjected to the in-depth morphological and immunohistochemical investigations. The tendency of angiogenesis (CD31 and CD34), proliferative activity (Ki-67), level of apoptosis (P53), EGFR expression were estimated. The sensitivity of combined endoscopic method was 94,74% by specificity 79,95% and high prognostic value of negative endoscopic diagnosis — 99,4%. |
| first_indexed | 2024-04-10T02:21:12Z |
| format | Article |
| id | doaj.art-f23cc95480aa4aa792518b0e79c8b756 |
| institution | Directory Open Access Journal |
| issn | 0042-4625 |
| language | Russian |
| last_indexed | 2024-04-10T02:21:12Z |
| publishDate | 2018-01-01 |
| publisher | Pavlov First Saint Petersburg State Medical University |
| record_format | Article |
| series | Вестник хирургии имени И.И. Грекова |
| spelling | doaj.art-f23cc95480aa4aa792518b0e79c8b7562023-03-13T08:09:14ZrusPavlov First Saint Petersburg State Medical UniversityВестник хирургии имени И.И. Грекова0042-46252018-01-01172501602010.24884/0042-4625-2013-172-5-016-020648MORPHOLOGICAL, IMMUNOHISTOCHEMICAL AND SPECTRAL CHARACTERISTICS OF DYSPLASIA, PREINVASIVE AND INVASIVE FORMS OF LUNG CANCERA. I. Arseniev0A. A. Barchuk1E. A. Zhelbunova2D. E. Matsko3A. S. Barchuk4E. V. Levchenko5K. E. Gagua6K. A. Kostitsyn7S. A. Tarkov8A. O. Nefyodov9N. N. Petrov research institute of oncologyN. N. Petrov research institute of oncologyN. N. Petrov research institute of oncologyN. N. Petrov research institute of oncologyN. N. Petrov research institute of oncologyN. N. Petrov research institute of oncologyN. N. Petrov research institute of oncologyN. N. Petrov research institute of oncologyN. N. Petrov research institute of oncologyN. N. Petrov research institute of oncologyAn analysis of modern methods of diagnostics such as morphological, immunohistochemical and spectral, which included the bronchoscopy and spectrometry by using reflectance and autofluorescent regime, was made. The data involved the results of prospective follow-up study of 167 patients (620 biopsies). An obligatory spectrometry of suspicious area was carried out before the forceps biopsy. The microslides, which met the requirements of criteria of one of the carcinogen steps (n=201), were subjected to the in-depth morphological and immunohistochemical investigations. The tendency of angiogenesis (CD31 and CD34), proliferative activity (Ki-67), level of apoptosis (P53), EGFR expression were estimated. The sensitivity of combined endoscopic method was 94,74% by specificity 79,95% and high prognostic value of negative endoscopic diagnosis — 99,4%.https://www.vestnik-grekova.ru/jour/article/view/649рак лёгкогобронхоскопиябиопсияаутофлюоресценцияlung cancerbiopsyautofluorescencebronchoscopy |
| spellingShingle | A. I. Arseniev A. A. Barchuk E. A. Zhelbunova D. E. Matsko A. S. Barchuk E. V. Levchenko K. E. Gagua K. A. Kostitsyn S. A. Tarkov A. O. Nefyodov MORPHOLOGICAL, IMMUNOHISTOCHEMICAL AND SPECTRAL CHARACTERISTICS OF DYSPLASIA, PREINVASIVE AND INVASIVE FORMS OF LUNG CANCER Вестник хирургии имени И.И. Грекова рак лёгкого бронхоскопия биопсия аутофлюоресценция lung cancer biopsy autofluorescence bronchoscopy |
| title | MORPHOLOGICAL, IMMUNOHISTOCHEMICAL AND SPECTRAL CHARACTERISTICS OF DYSPLASIA, PREINVASIVE AND INVASIVE FORMS OF LUNG CANCER |
| title_full | MORPHOLOGICAL, IMMUNOHISTOCHEMICAL AND SPECTRAL CHARACTERISTICS OF DYSPLASIA, PREINVASIVE AND INVASIVE FORMS OF LUNG CANCER |
| title_fullStr | MORPHOLOGICAL, IMMUNOHISTOCHEMICAL AND SPECTRAL CHARACTERISTICS OF DYSPLASIA, PREINVASIVE AND INVASIVE FORMS OF LUNG CANCER |
| title_full_unstemmed | MORPHOLOGICAL, IMMUNOHISTOCHEMICAL AND SPECTRAL CHARACTERISTICS OF DYSPLASIA, PREINVASIVE AND INVASIVE FORMS OF LUNG CANCER |
| title_short | MORPHOLOGICAL, IMMUNOHISTOCHEMICAL AND SPECTRAL CHARACTERISTICS OF DYSPLASIA, PREINVASIVE AND INVASIVE FORMS OF LUNG CANCER |
| title_sort | morphological immunohistochemical and spectral characteristics of dysplasia preinvasive and invasive forms of lung cancer |
| topic | рак лёгкого бронхоскопия биопсия аутофлюоресценция lung cancer biopsy autofluorescence bronchoscopy |
| url | https://www.vestnik-grekova.ru/jour/article/view/649 |
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