The Emerging Functions of Circular RNAs in Bladder Cancer
Bladder cancer (BC) is among the top ten most common cancer types worldwide and is a serious threat to human health. Circular RNAs (circRNAs) are a new class of non-coding RNAs generated by covalently closed loops through back-splicing. As an emerging research hotspot, circRNAs have attracted consid...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-09-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/13/18/4618 |
| _version_ | 1797520013196787712 |
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| author | Kai Sun Di Wang Burton B. Yang Jian Ma |
| author_facet | Kai Sun Di Wang Burton B. Yang Jian Ma |
| author_sort | Kai Sun |
| collection | DOAJ |
| description | Bladder cancer (BC) is among the top ten most common cancer types worldwide and is a serious threat to human health. Circular RNAs (circRNAs) are a new class of non-coding RNAs generated by covalently closed loops through back-splicing. As an emerging research hotspot, circRNAs have attracted considerable attention due to their high conservation, stability, abundance, and specificity of tissue development. Accumulating evidence has revealed different form of circRNAs are closely related to the malignant phenotype, prognosis and chemotherapy resistance of BC, suggesting that different circRNAs may be promising biomarkers and have therapeutic significance in BC. The intention of this review is to summarize the mechanisms of circRNA-mediated BC progression and their diagnostic and prognostic value as biomarkers, as well as to further explore their roles in chemotherapy resistance. |
| first_indexed | 2024-03-10T07:50:49Z |
| format | Article |
| id | doaj.art-f23ce0306bca471d819a32e4a9944ef6 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T07:50:49Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-f23ce0306bca471d819a32e4a9944ef62023-11-22T12:17:59ZengMDPI AGCancers2072-66942021-09-011318461810.3390/cancers13184618The Emerging Functions of Circular RNAs in Bladder CancerKai Sun0Di Wang1Burton B. Yang2Jian Ma3Urology Department, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai 264000, Shandong, ChinaUrology Department, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai 264000, Shandong, ChinaDepartment of Laboratory Medicine and Pathobiology, Sunnybrook Research Institute, University of Toronto, Research Building, 2075 Bayview Avenue, Toronto, ON M4N 3M5, CanadaUrology Department, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai 264000, Shandong, ChinaBladder cancer (BC) is among the top ten most common cancer types worldwide and is a serious threat to human health. Circular RNAs (circRNAs) are a new class of non-coding RNAs generated by covalently closed loops through back-splicing. As an emerging research hotspot, circRNAs have attracted considerable attention due to their high conservation, stability, abundance, and specificity of tissue development. Accumulating evidence has revealed different form of circRNAs are closely related to the malignant phenotype, prognosis and chemotherapy resistance of BC, suggesting that different circRNAs may be promising biomarkers and have therapeutic significance in BC. The intention of this review is to summarize the mechanisms of circRNA-mediated BC progression and their diagnostic and prognostic value as biomarkers, as well as to further explore their roles in chemotherapy resistance.https://www.mdpi.com/2072-6694/13/18/4618circular RNAbladder cancerbiomarkersignaling pathwaysdrug resistance |
| spellingShingle | Kai Sun Di Wang Burton B. Yang Jian Ma The Emerging Functions of Circular RNAs in Bladder Cancer Cancers circular RNA bladder cancer biomarker signaling pathways drug resistance |
| title | The Emerging Functions of Circular RNAs in Bladder Cancer |
| title_full | The Emerging Functions of Circular RNAs in Bladder Cancer |
| title_fullStr | The Emerging Functions of Circular RNAs in Bladder Cancer |
| title_full_unstemmed | The Emerging Functions of Circular RNAs in Bladder Cancer |
| title_short | The Emerging Functions of Circular RNAs in Bladder Cancer |
| title_sort | emerging functions of circular rnas in bladder cancer |
| topic | circular RNA bladder cancer biomarker signaling pathways drug resistance |
| url | https://www.mdpi.com/2072-6694/13/18/4618 |
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