Assessment of Fraction of Exhaled Nitric Oxide and Soluble Receptor for Advanced Glycation End Products Biomarkers for Jordanian Asthmatic Children
Ebaa M Alzayadneh,1 Suzan A Al Bdour,1 Eman R Elayeh,2 Mai M Ababneh,3 Ruqaya A Al-ani,3 Alia Shatanawi,4 Montaha Al-Iede,3 Enas Al-Zayadneh3 1Department of Physiology and Biochemistry, School of Medicine, The University of Jordan, Amman, Jordan; 2Department of Biopharmaceutics and Clinical Pharmacy...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2023-08-01
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| Series: | Journal of Asthma and Allergy |
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| Online Access: | https://www.dovepress.com/assessment-of-fraction-of-exhaled-nitric-oxide-and-soluble-receptor-fo-peer-reviewed-fulltext-article-JAA |
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| author | Alzayadneh EM Al Bdour SA Elayeh ER Ababneh MM Al-ani RA Shatanawi A Al-Iede M Al-Zayadneh E |
| author_facet | Alzayadneh EM Al Bdour SA Elayeh ER Ababneh MM Al-ani RA Shatanawi A Al-Iede M Al-Zayadneh E |
| author_sort | Alzayadneh EM |
| collection | DOAJ |
| description | Ebaa M Alzayadneh,1 Suzan A Al Bdour,1 Eman R Elayeh,2 Mai M Ababneh,3 Ruqaya A Al-ani,3 Alia Shatanawi,4 Montaha Al-Iede,3 Enas Al-Zayadneh3 1Department of Physiology and Biochemistry, School of Medicine, The University of Jordan, Amman, Jordan; 2Department of Biopharmaceutics and Clinical Pharmacy, School of Pharmacy, The University of Jordan, Amman, Jordan; 3Department of Pediatrics, School of Medicine, The University of Jordan, Amman, Jordan; 4Department of Pharmacology, School of Medicine, The University of Jordan, Amman, JordanCorrespondence: Ebaa M Alzayadneh, Tel +962796972717, Fax +96265300820, Email e.zayadneh@ju.edu.joPurpose: Fraction of exhaled nitric oxide (FeNO) and soluble advanced glycation end-product receptor (sRAGE) are proposed as biomarkers of asthma, therefore we sought to assess their use in asthmatic children of Jordan.Patients and Methods: We conducted a case-control study at The University of Jordan Hospital. A total of 141 asthmatic children followed by respiratory pediatricians and 118 healthy children aged 4– 18 years were recruited. FeNO was measured by NObreath device and serum sRAGE by ELISA that detect endogenously soluble isoform (esRAGE) and total soluble RAGE (sRAGE).Results: sRAGE in asthmatic was half of the control (p < 0.001). In addition, ratio of esRAGE/sRAGE was two-fold higher in asthmatic (p = < 0.001). Neither FeNO nor esRAGE levels were significantly different between groups. FeNO and asthma control test (ACT) score were negatively correlated corrected for age and body mass index (BMI), (r = − 0.180, p= 0.034). For the uncontrolled asthma group, esRAGE/sRAGE negatively correlated with ACT score (r = − .329, p = 0.038). Receiver operating curve (ROC) analysis revealed significant predictive value (PV) for sRAGE and esRAGE/sRAGE in asthma detection with area under the curve (AUC) of (0.751 ± 0.031) and (0.711± .033), consequently. However, no biomarker had a significant PV for lack of control.Conclusion: The current study supports utilizing sRAGE as a marker for asthma and present a potential therapeutic target. However, our results indicate that both FeNO and sRAGE have a limited role in the management of asthmatic children or assessment of asthma control.Keywords: childhood asthma, allergy, inflammation, asthma control test |
| first_indexed | 2024-03-12T17:45:09Z |
| format | Article |
| id | doaj.art-f23cf30f6e3344f693e952e0f6010563 |
| institution | Directory Open Access Journal |
| issn | 1178-6965 |
| language | English |
| last_indexed | 2024-03-12T17:45:09Z |
| publishDate | 2023-08-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Journal of Asthma and Allergy |
| spelling | doaj.art-f23cf30f6e3344f693e952e0f60105632023-08-03T19:02:12ZengDove Medical PressJournal of Asthma and Allergy1178-69652023-08-01Volume 1679381185668Assessment of Fraction of Exhaled Nitric Oxide and Soluble Receptor for Advanced Glycation End Products Biomarkers for Jordanian Asthmatic ChildrenAlzayadneh EMAl Bdour SAElayeh ERAbabneh MMAl-ani RAShatanawi AAl-Iede MAl-Zayadneh EEbaa M Alzayadneh,1 Suzan A Al Bdour,1 Eman R Elayeh,2 Mai M Ababneh,3 Ruqaya A Al-ani,3 Alia Shatanawi,4 Montaha Al-Iede,3 Enas Al-Zayadneh3 1Department of Physiology and Biochemistry, School of Medicine, The University of Jordan, Amman, Jordan; 2Department of Biopharmaceutics and Clinical Pharmacy, School of Pharmacy, The University of Jordan, Amman, Jordan; 3Department of Pediatrics, School of Medicine, The University of Jordan, Amman, Jordan; 4Department of Pharmacology, School of Medicine, The University of Jordan, Amman, JordanCorrespondence: Ebaa M Alzayadneh, Tel +962796972717, Fax +96265300820, Email e.zayadneh@ju.edu.joPurpose: Fraction of exhaled nitric oxide (FeNO) and soluble advanced glycation end-product receptor (sRAGE) are proposed as biomarkers of asthma, therefore we sought to assess their use in asthmatic children of Jordan.Patients and Methods: We conducted a case-control study at The University of Jordan Hospital. A total of 141 asthmatic children followed by respiratory pediatricians and 118 healthy children aged 4– 18 years were recruited. FeNO was measured by NObreath device and serum sRAGE by ELISA that detect endogenously soluble isoform (esRAGE) and total soluble RAGE (sRAGE).Results: sRAGE in asthmatic was half of the control (p < 0.001). In addition, ratio of esRAGE/sRAGE was two-fold higher in asthmatic (p = < 0.001). Neither FeNO nor esRAGE levels were significantly different between groups. FeNO and asthma control test (ACT) score were negatively correlated corrected for age and body mass index (BMI), (r = − 0.180, p= 0.034). For the uncontrolled asthma group, esRAGE/sRAGE negatively correlated with ACT score (r = − .329, p = 0.038). Receiver operating curve (ROC) analysis revealed significant predictive value (PV) for sRAGE and esRAGE/sRAGE in asthma detection with area under the curve (AUC) of (0.751 ± 0.031) and (0.711± .033), consequently. However, no biomarker had a significant PV for lack of control.Conclusion: The current study supports utilizing sRAGE as a marker for asthma and present a potential therapeutic target. However, our results indicate that both FeNO and sRAGE have a limited role in the management of asthmatic children or assessment of asthma control.Keywords: childhood asthma, allergy, inflammation, asthma control testhttps://www.dovepress.com/assessment-of-fraction-of-exhaled-nitric-oxide-and-soluble-receptor-fo-peer-reviewed-fulltext-article-JAAchildhood asthmaallergyinflammationasthma control test |
| spellingShingle | Alzayadneh EM Al Bdour SA Elayeh ER Ababneh MM Al-ani RA Shatanawi A Al-Iede M Al-Zayadneh E Assessment of Fraction of Exhaled Nitric Oxide and Soluble Receptor for Advanced Glycation End Products Biomarkers for Jordanian Asthmatic Children Journal of Asthma and Allergy childhood asthma allergy inflammation asthma control test |
| title | Assessment of Fraction of Exhaled Nitric Oxide and Soluble Receptor for Advanced Glycation End Products Biomarkers for Jordanian Asthmatic Children |
| title_full | Assessment of Fraction of Exhaled Nitric Oxide and Soluble Receptor for Advanced Glycation End Products Biomarkers for Jordanian Asthmatic Children |
| title_fullStr | Assessment of Fraction of Exhaled Nitric Oxide and Soluble Receptor for Advanced Glycation End Products Biomarkers for Jordanian Asthmatic Children |
| title_full_unstemmed | Assessment of Fraction of Exhaled Nitric Oxide and Soluble Receptor for Advanced Glycation End Products Biomarkers for Jordanian Asthmatic Children |
| title_short | Assessment of Fraction of Exhaled Nitric Oxide and Soluble Receptor for Advanced Glycation End Products Biomarkers for Jordanian Asthmatic Children |
| title_sort | assessment of fraction of exhaled nitric oxide and soluble receptor for advanced glycation end products biomarkers for jordanian asthmatic children |
| topic | childhood asthma allergy inflammation asthma control test |
| url | https://www.dovepress.com/assessment-of-fraction-of-exhaled-nitric-oxide-and-soluble-receptor-fo-peer-reviewed-fulltext-article-JAA |
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