Decreased renal function among children born to women with obstructed labour in Eastern Uganda: a cohort study
Abstract Background Over two million children and adolescents suffer from chronic kidney disease globally. Early childhood insults such as birth asphyxia could be risk factors for chronic kidney disease in later life. Our study aimed to assess renal function among children aged two to four years, bo...
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2024-03-01
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| Series: | BMC Nephrology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12882-024-03552-8 |
| _version_ | 1827301359686254592 |
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| author | David Mukunya Faith Oguttu Brendah Nambozo Ritah Nantale Brian Tonny Makoko Agnes Napyo Josephine Tumuhamye Solomon Wani Prossy Auma Ketty Atim Doreck Nahurira Dedan Okello Joan Wamulugwa Lawrence Ssegawa Julius Wandabwa Sarah Kiguli Martin Chebet Milton W. Musaba |
| author_facet | David Mukunya Faith Oguttu Brendah Nambozo Ritah Nantale Brian Tonny Makoko Agnes Napyo Josephine Tumuhamye Solomon Wani Prossy Auma Ketty Atim Doreck Nahurira Dedan Okello Joan Wamulugwa Lawrence Ssegawa Julius Wandabwa Sarah Kiguli Martin Chebet Milton W. Musaba |
| author_sort | David Mukunya |
| collection | DOAJ |
| description | Abstract Background Over two million children and adolescents suffer from chronic kidney disease globally. Early childhood insults such as birth asphyxia could be risk factors for chronic kidney disease in later life. Our study aimed to assess renal function among children aged two to four years, born to women with obstructed labour. Methods We followed up 144 children aged two to four years, born to women with obstructed labor at Mbale regional referral hospital in Eastern Uganda. We used serum creatinine to calculate estimated glomerular filtration rate (eGFR) using the Schwartz formula. We defined decreased renal function as eGFR less than 90 ml/min/1.73m2. Results The mean age of the children was 2.8 years, standard deviation (SD) of 0.4 years. Majority of the children were male (96/144: 66.7%). The mean umbilical lactate level at birth among the study participants was 8.9 mmol/L with a standard deviation (SD) of 5.0. eGFR of the children ranged from 55 to 163 ml/min/1.73m2, mean 85.8 ± SD 15.9. Nearly one third of the children (45/144) had normal eGFR (> 90 ml/Min/1.73m2), two thirds (97/144) had a mild decrease of eGFR (60–89 ml/Min/1.73m2), and only two children had a moderate decrease of eGFR (< 60 ml/Min/1.73m2). Overall incidence of reduced eGFR was 68.8% [(99/144): 95% CI (60.6 to 75.9)]. Conclusion We observed a high incidence of reduced renal function among children born to women with obstructed labour. We recommend routine follow up of children born to women with obstructed labour and add our voices to those calling for improved intra-partum and peripartum care. |
| first_indexed | 2024-04-24T16:21:49Z |
| format | Article |
| id | doaj.art-f240a1d33a8542ed9160bd7c9bdbe7a6 |
| institution | Directory Open Access Journal |
| issn | 1471-2369 |
| language | English |
| last_indexed | 2024-04-24T16:21:49Z |
| publishDate | 2024-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Nephrology |
| spelling | doaj.art-f240a1d33a8542ed9160bd7c9bdbe7a62024-03-31T11:12:43ZengBMCBMC Nephrology1471-23692024-03-012511810.1186/s12882-024-03552-8Decreased renal function among children born to women with obstructed labour in Eastern Uganda: a cohort studyDavid Mukunya0Faith Oguttu1Brendah Nambozo2Ritah Nantale3Brian Tonny Makoko4Agnes Napyo5Josephine Tumuhamye6Solomon Wani7Prossy Auma8Ketty Atim9Doreck Nahurira10Dedan Okello11Joan Wamulugwa12Lawrence Ssegawa13Julius Wandabwa14Sarah Kiguli15Martin Chebet16Milton W. Musaba17Department of Community and Public Health, Busitema UniversityDepartment of Community and Public Health, Busitema UniversityDepartment of Community and Public Health, Busitema UniversityDepartment of Obstetrics and Gynecology, Busitema UniversityDepartment of Community and Public Health, Busitema UniversityDepartment of Community and Public Health, Busitema UniversityMakerere University Hospital, Makerere University KampalaDepartment of Community and Public Health, Busitema UniversityMbale Regional Referral HospitalMbale Regional Referral HospitalDepartment of Obstetrics and Gynecology, Busitema UniversityDepartment of Paediatrics and Child Health, Busitema UniversityMbale Regional Referral HospitalDepartment of Research, Sanyu Africa Research InstituteDepartment of Obstetrics and Gynecology, Busitema UniversityDepartment of Paediatrics and Child Health, Makerere UniversityDepartment of Paediatrics and Child Health, Busitema UniversityDepartment of Obstetrics and Gynecology, Busitema UniversityAbstract Background Over two million children and adolescents suffer from chronic kidney disease globally. Early childhood insults such as birth asphyxia could be risk factors for chronic kidney disease in later life. Our study aimed to assess renal function among children aged two to four years, born to women with obstructed labour. Methods We followed up 144 children aged two to four years, born to women with obstructed labor at Mbale regional referral hospital in Eastern Uganda. We used serum creatinine to calculate estimated glomerular filtration rate (eGFR) using the Schwartz formula. We defined decreased renal function as eGFR less than 90 ml/min/1.73m2. Results The mean age of the children was 2.8 years, standard deviation (SD) of 0.4 years. Majority of the children were male (96/144: 66.7%). The mean umbilical lactate level at birth among the study participants was 8.9 mmol/L with a standard deviation (SD) of 5.0. eGFR of the children ranged from 55 to 163 ml/min/1.73m2, mean 85.8 ± SD 15.9. Nearly one third of the children (45/144) had normal eGFR (> 90 ml/Min/1.73m2), two thirds (97/144) had a mild decrease of eGFR (60–89 ml/Min/1.73m2), and only two children had a moderate decrease of eGFR (< 60 ml/Min/1.73m2). Overall incidence of reduced eGFR was 68.8% [(99/144): 95% CI (60.6 to 75.9)]. Conclusion We observed a high incidence of reduced renal function among children born to women with obstructed labour. We recommend routine follow up of children born to women with obstructed labour and add our voices to those calling for improved intra-partum and peripartum care.https://doi.org/10.1186/s12882-024-03552-8Renal functionChildrenObstructed laboureGFRUganda |
| spellingShingle | David Mukunya Faith Oguttu Brendah Nambozo Ritah Nantale Brian Tonny Makoko Agnes Napyo Josephine Tumuhamye Solomon Wani Prossy Auma Ketty Atim Doreck Nahurira Dedan Okello Joan Wamulugwa Lawrence Ssegawa Julius Wandabwa Sarah Kiguli Martin Chebet Milton W. Musaba Decreased renal function among children born to women with obstructed labour in Eastern Uganda: a cohort study BMC Nephrology Renal function Children Obstructed labour eGFR Uganda |
| title | Decreased renal function among children born to women with obstructed labour in Eastern Uganda: a cohort study |
| title_full | Decreased renal function among children born to women with obstructed labour in Eastern Uganda: a cohort study |
| title_fullStr | Decreased renal function among children born to women with obstructed labour in Eastern Uganda: a cohort study |
| title_full_unstemmed | Decreased renal function among children born to women with obstructed labour in Eastern Uganda: a cohort study |
| title_short | Decreased renal function among children born to women with obstructed labour in Eastern Uganda: a cohort study |
| title_sort | decreased renal function among children born to women with obstructed labour in eastern uganda a cohort study |
| topic | Renal function Children Obstructed labour eGFR Uganda |
| url | https://doi.org/10.1186/s12882-024-03552-8 |
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