ENOX2 NADH Oxidase: A BCR-ABL1-Dependent Cell Surface and Secreted Redox Protein in Chronic Myeloid Leukemia

ENOX2 NADH Oxidase: A BCR-ABL1-Dependent Cell Surface and Secreted Redox Protein in Chronic Myeloid Leukemia

Objective: Chronic myeloid leukemia (CML) is a disease caused by the acquisition of BCR-ABL1 fusion in hematopoietic stem cells. In this study, we focus on the oncofetal ENOX2 protein as a potential secretable biomarker in CML. Materials and Methods: We used cell culture, western blot, quantitative...

Full description

Bibliographic Details
Main Authors:	Seda Baykal, Maud Voldoire, Christophe Desterke, Nathalie Sorel, Emilie Cayssials, Hyacinthe Johnson-Ansah, Agnes Guerci-Bresler, Annelise Bennaceur-Griscelli, Jean-Claude Chome, Ali G. Turhan
Format:	Article
Language:	English
Published:	Galenos Publishing House 2023-06-01
Series:	Turkish Journal of Hematology
Subjects:	cml enox2 biomarker chronic myeloid leukemia redox protein secreted protein
Online Access:	https://tjh.com.tr/jvi.aspx?pdir=tjh&plng=eng&un=TJH-21447&look4=

Similar Items

Expression profilingof Ecto-NOX Disulfide-Thiol Exchanger 2 (ENOX2) gene during heat stress in Attappady black and Malabari goats
by: Aishwary Vibhuti, et al.
Published: (2022-09-01)

Rapid and Quantitative Detection of Lung Cancer Biomarker ENOX2 Using a Novel Aptamer in an Electrochemical DNA-Based (E-DNA) Biosensor
by: Mary Quansah, et al.
Published: (2023-06-01)

ENOX2 inhibition enhances infiltration of effector memory T-cell and mediates response to chemotherapy in immune-quiescent nasopharyngeal carcinoma
by: Ngar-Woon Kam, et al.
Published: (2024-02-01)

Deciphering Potential Molecular Signatures to Differentiate Acute Myeloid Leukemia (AML) with <i>BCR::ABL1</i> from Chronic Myeloid Leukemia (CML) in Blast Crisis
by: Lara Boucher, et al.
Published: (2023-10-01)

Modeling Blast Crisis Using Mutagenized Chronic Myeloid Leukemia-Derived Induced Pluripotent Stem Cells (iPSCs)
by: Jusuf Imeri, et al.
Published: (2023-02-01)

Case report: Long-term voluntary Tyrosine Kinase Inhibitor (TKI) discontinuation in chronic myeloid leukemia (CML): Molecular evidence of an immune surveillance
by: Jusuf Imeri, et al.
Published: (2023-03-01)

Chimeric antigen-receptor (CAR) engineered natural killer cells in a chronic myeloid leukemia (CML) blast crisis model
by: Jusuf Imeri, et al.
Published: (2024-01-01)

Capsaicin Targets tNOX (ENOX2) to Inhibit G1 Cyclin/CDK Complex, as Assessed by the Cellular Thermal Shift Assay (CETSA)
by: Atikul Islam, et al.
Published: (2019-10-01)

Modeling Global Genomic Instability in Chronic Myeloid Leukemia (CML) Using Patient-Derived Induced Pluripotent Stem Cells (iPSCs)
by: Gladys Telliam, et al.
Published: (2023-05-01)

Engagement with tNOX (ENOX2) to Inhibit SIRT1 and Activate p53-Dependent and -Independent Apoptotic Pathways by Novel 4,11-Diaminoanthra[2,3-<i>b</i>]furan-5,10-diones in Hepatocellular Carcinoma Cells
by: Chia-Yang Lin, et al.
Published: (2019-03-01)

Frequency of BCR-ABL Fusion Transcript in Iranian Patients with Chronic Myeloid Leukemia
by: M Yaghmaie, et al.
Published: (2005-09-01)

Frequency of BCR-ABL Fusion Transcript in Iranian Patients with Chronic Myeloid Leukemia
by: Yaghmaie M., et al.
Published: (2005-09-01)

Chronic Myeloid Leukaemia with isolated massive thrombocytosis and BCR‐ABL1 detection failure using RT‐MLPA (positive RT‐qPCR)
by: Lucie Coster, et al.
Published: (2021-08-01)

HLA-dependent heterogeneity and macrophage immunoproteasome activation during lung COVID-19 disease
by: Christophe Desterke, et al.
Published: (2021-07-01)

PPARγ Cistrome Repression during Activation of Lung Monocyte-Macrophages in Severe COVID-19
by: Christophe Desterke, et al.
Published: (2020-10-01)

EGR1 dysregulation defines an inflammatory and leukemic program in cell trajectory of human-aged hematopoietic stem cells (HSC)
by: Christophe Desterke, et al.
Published: (2021-07-01)

Detection of Hematopoietic Stem Cell Transcriptome in Human Fetal Kidneys and Kidney Organoids Derived From Human Induced Pluripotent Stem Cells
by: Jin Wook Hwang, et al.
Published: (2021-06-01)

Critical Requirement of SOS1 for Development of BCR/ABL-Driven Chronic Myelogenous Leukemia
by: Carmela Gómez, et al.
Published: (2022-08-01)

Design, synthesis, and biological evaluation of Bcr-Abl PROTACs to overcome T315I mutation
by: Liang Jiang, et al.
Published: (2021-05-01)

Fusion gene bcr-abl: From etiopathogenesis to the management of chronic myeloid leukemia
by: Tri Agusti Sholikah
Published: (2017-04-01)

Association of BCR/ABL transcript variants with different blood parameters and demographic features in Iraqi chronic myeloid leukemia patients
by: Mahmood S. Khazaal, et al.
Published: (2019-08-01)

The Spliceosome: A New Therapeutic Target in Chronic Myeloid Leukaemia
by: Benjamin Lebecque, et al.
Published: (2022-09-01)

NPM1 MUTATED, BCR-ABL1 POSITIVE MYELOID NEOPLASMS: REVIEW OF LITERATURE
by: Gianfranco Catalano, et al.
Published: (2020-10-01)

Aryl hydrocarbon receptor (AHR) is a novel druggable pathway controlling malignant progenitor proliferation in chronic myeloid leukemia (CML).
by: Melanie Gentil, et al.
Published: (2018-01-01)

Evaluation of secreted frizzled-related protein-4 methylation profiles in patients with BCR/ABL positive chronic myeloid leukemia
by: M. Pehlivan, et al.
Published: (2021-05-01)

A Study on BCR-ABL Kinase Domain Mutations in Chronic Myeloid Leukemia from Western India
by: Pankaj Gadhia, et al.
Published: (2021-10-01)

Cross-talk between Bcr-abl and the Thioredoxin System in Chronic Myeloid Leukaemia: Implications for CML Treatment
by: Erin Clapper, et al.
Published: (2020-03-01)

Higher incidence of co-expression of BCR-ABL fusion transcripts in an Eastern Indian population
by: Ajeet Kumar, et al.
Published: (2023-10-01)

Small Molecules as Potential Inhibitors of the 14-3-3/c-Abl Interaction for the Treatment of CML
by: Leire Iralde-Lorente, et al.
Published: (2019-08-01)

Capsaicin Inhibits Multiple Bladder Cancer Cell Phenotypes by Inhibiting Tumor-Associated NADH Oxidase (tNOX) and Sirtuin1 (SIRT1)
by: Ming-Hung Lin, et al.
Published: (2016-06-01)

The molecular mechanisms underlying BCR/ABL degradation in chronic myeloid leukemia cells promoted by Beclin1-mediated autophagy
by: Huang X, et al.
Published: (2019-06-01)

iPSC-Derived Organoids as Therapeutic Models in Regenerative Medicine and Oncology
by: Ali G. Turhan, et al.
Published: (2021-10-01)

Investigation of the mechanism of USP28-mediated IFITM3 elevation in BCR-ABL-dependent imatinib resistance in CML
by: Zilin Li, et al.
Published: (2024-04-01)

Molecular diagnosis of bcr-abl fusion gene in CML patients using Monoplex-Two Steps- Reveres Transcriptase–Polymerase Chain
by: Maysaa A. Dhahii
Published: (2010-04-01)

Molecular Pathogenesis of BCR-ABL-Negative Atypical Chronic Myeloid Leukemia
by: Diletta Fontana, et al.
Published: (2021-11-01)

Overcoming the imatinib-resistant BCR-ABL mutants with new ureidobenzothiazole chemotypes endowed with potent and broad-spectrum anticancer activity
by: Ashraf K. El-Damasy, et al.
Published: (2023-12-01)

Cysteine Mediated Formation of N-ε -Carboxymethyllysine (CML) on Proteins
by: U. Schwarzenbolz, et al.
Published: (2009-06-01)

The role of isoflavones in augmenting the effects of radiotherapy
by: Alesia Ivashkevich, et al.
Published: (2023-03-01)

Impact of the Breakpoint Region on the Leukemogenic Potential and the TKI Responsiveness of Atypical BCR-ABL1 Transcripts
by: Michele Massimino, et al.
Published: (2021-06-01)

Tailored CML Treatment in Indonesia, Let’s See More
by: Shinta Oktya Wardhani
Published: (2023-11-01)