Idiopathic splenomegaly in childhood and the spectrum of RAS-associated lymphoproliferative disease: a case report

Idiopathic splenomegaly in childhood and the spectrum of RAS-associated lymphoproliferative disease: a case report

Abstract Background KRAS (KRAS proto-oncogene, GTPase; OMIM: 190,070) encodes one of three small guanosine triphosphatase proteins belonging to the RAS family. This group of proteins is responsible for cell proliferation, differentiation and inhibition of apoptosis. Gain-of-function variants in KRAS...

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Main Authors: Geraldine Blanchard-Rohner, Robert J. Ragotte, Anne K. Junker, Mehul Sharma, Kate L. Del Bel, Henry Y. Lu, Stephanie Erdle, Alanna Chomyn, Harinder Gill, Lori B. Tucker, Richard A. Schreiber, Jacob Rozmus, Catherine M. Biggs, Kyla J. Hildebrand, John Wu, Sylvia Stockler-Ipsiroglu, Stuart E. Turvey
Format: Article
Language:English
Published: BMC 2021-01-01
Series:BMC Pediatrics
Subjects:
RAS-associated lymphoproliferative disease
KRAS
Splenomegaly
Case report
Online Access:https://doi.org/10.1186/s12887-021-02508-3

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