The chromatin remodeling factor ISW-1 integrates organismal responses against nuclear and mitochondrial stress
Changes in chromatin structure have been linked to organismal ageing. Here the authors show that altered histone expression and mitochondrial stress during C. elegans development result in chromatin changes and a cytosolic stress response that affects organismal longevity, and depends on HSF-1 and t...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2017-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-017-01903-8 |
| _version_ | 1818839170046492672 |
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| author | Olli Matilainen Maroun S. Bou Sleiman Pedro M. Quiros Susana M. D. A. Garcia Johan Auwerx |
| author_facet | Olli Matilainen Maroun S. Bou Sleiman Pedro M. Quiros Susana M. D. A. Garcia Johan Auwerx |
| author_sort | Olli Matilainen |
| collection | DOAJ |
| description | Changes in chromatin structure have been linked to organismal ageing. Here the authors show that altered histone expression and mitochondrial stress during C. elegans development result in chromatin changes and a cytosolic stress response that affects organismal longevity, and depends on HSF-1 and the chromatin remodeller, ISW-1. |
| first_indexed | 2024-12-19T03:50:02Z |
| format | Article |
| id | doaj.art-f2448e82fe1a47ca8ebd24b4a5a05de3 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T03:50:02Z |
| publishDate | 2017-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-f2448e82fe1a47ca8ebd24b4a5a05de32022-12-21T20:37:02ZengNature PortfolioNature Communications2041-17232017-11-018111110.1038/s41467-017-01903-8The chromatin remodeling factor ISW-1 integrates organismal responses against nuclear and mitochondrial stressOlli Matilainen0Maroun S. Bou Sleiman1Pedro M. Quiros2Susana M. D. A. Garcia3Johan Auwerx4Laboratory for Integrative and Systems Physiology, Institute of Bioengineering, École Polytechnique Fédérale de LausanneLaboratory for Integrative and Systems Physiology, Institute of Bioengineering, École Polytechnique Fédérale de LausanneLaboratory for Integrative and Systems Physiology, Institute of Bioengineering, École Polytechnique Fédérale de LausanneInstitute of Biotechnology, University of HelsinkiLaboratory for Integrative and Systems Physiology, Institute of Bioengineering, École Polytechnique Fédérale de LausanneChanges in chromatin structure have been linked to organismal ageing. Here the authors show that altered histone expression and mitochondrial stress during C. elegans development result in chromatin changes and a cytosolic stress response that affects organismal longevity, and depends on HSF-1 and the chromatin remodeller, ISW-1.https://doi.org/10.1038/s41467-017-01903-8 |
| spellingShingle | Olli Matilainen Maroun S. Bou Sleiman Pedro M. Quiros Susana M. D. A. Garcia Johan Auwerx The chromatin remodeling factor ISW-1 integrates organismal responses against nuclear and mitochondrial stress Nature Communications |
| title | The chromatin remodeling factor ISW-1 integrates organismal responses against nuclear and mitochondrial stress |
| title_full | The chromatin remodeling factor ISW-1 integrates organismal responses against nuclear and mitochondrial stress |
| title_fullStr | The chromatin remodeling factor ISW-1 integrates organismal responses against nuclear and mitochondrial stress |
| title_full_unstemmed | The chromatin remodeling factor ISW-1 integrates organismal responses against nuclear and mitochondrial stress |
| title_short | The chromatin remodeling factor ISW-1 integrates organismal responses against nuclear and mitochondrial stress |
| title_sort | chromatin remodeling factor isw 1 integrates organismal responses against nuclear and mitochondrial stress |
| url | https://doi.org/10.1038/s41467-017-01903-8 |
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