Modulation of synaptic transmission through O-GlcNAcylation
Abstract O-GlcNAcylation is a posttranslational modification where N-acetylglucosamine (O-GlcNAc) is attached and detached from a serine/threonine position by two enzymes: O-GlcNAc transferase and O-GlcNAcase. In addition to roles in diabetes and cancer, recent pharmacological and genetic studies ha...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2024-01-01
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| Series: | Molecular Brain |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13041-023-01072-4 |
| _version_ | 1827388035303473152 |
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| author | Seunghyo Han Jun-Nyeong Kim Chan Ho Park Jin-Seok Byun Do-Yeon Kim Hyoung-Gon Ko |
| author_facet | Seunghyo Han Jun-Nyeong Kim Chan Ho Park Jin-Seok Byun Do-Yeon Kim Hyoung-Gon Ko |
| author_sort | Seunghyo Han |
| collection | DOAJ |
| description | Abstract O-GlcNAcylation is a posttranslational modification where N-acetylglucosamine (O-GlcNAc) is attached and detached from a serine/threonine position by two enzymes: O-GlcNAc transferase and O-GlcNAcase. In addition to roles in diabetes and cancer, recent pharmacological and genetic studies have revealed that O-GlcNAcylation is involved in neuronal function, specifically synaptic transmission. Global alteration of the O-GlcNAc level does not affect basal synaptic transmission while the effect on synaptic plasticity is unclear. Although synaptic proteins that are O-GlcNAcylated are gradually being discovered, the mechanism of how O-GlcNAcylated synaptic protein modulate synaptic transmission has only been reported on CREB, synapsin, and GluA2 subunit of AMPAR. Future research enabling the manipulation of O-GlcNAcylation in individual synaptic proteins should reveal hidden aspects of O-GlcNAcylated synaptic proteins as modulators of synaptic transmission. |
| first_indexed | 2024-03-08T16:11:56Z |
| format | Article |
| id | doaj.art-f244f89df39441bf880703a7d96ab253 |
| institution | Directory Open Access Journal |
| issn | 1756-6606 |
| language | English |
| last_indexed | 2024-03-08T16:11:56Z |
| publishDate | 2024-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Molecular Brain |
| spelling | doaj.art-f244f89df39441bf880703a7d96ab2532024-01-07T12:54:59ZengBMCMolecular Brain1756-66062024-01-011711510.1186/s13041-023-01072-4Modulation of synaptic transmission through O-GlcNAcylationSeunghyo Han0Jun-Nyeong Kim1Chan Ho Park2Jin-Seok Byun3Do-Yeon Kim4Hyoung-Gon Ko5Department of Anatomy and Neurobiology, School of Dentistry, Brain Science and Engineering Institute, Kyungpook National UniversityDepartment of Anatomy and Neurobiology, School of Dentistry, Brain Science and Engineering Institute, Kyungpook National UniversityDepartment of Dental Biomaterials, School of Dentistry, Kyungpook National UniversityDepartment of Oral Medicine, School of Dentistry, Kyungpook National UniversityDepartment of Pharmacology, School of Dentistry, Kyungpook National UniversityDepartment of Anatomy and Neurobiology, School of Dentistry, Brain Science and Engineering Institute, Kyungpook National UniversityAbstract O-GlcNAcylation is a posttranslational modification where N-acetylglucosamine (O-GlcNAc) is attached and detached from a serine/threonine position by two enzymes: O-GlcNAc transferase and O-GlcNAcase. In addition to roles in diabetes and cancer, recent pharmacological and genetic studies have revealed that O-GlcNAcylation is involved in neuronal function, specifically synaptic transmission. Global alteration of the O-GlcNAc level does not affect basal synaptic transmission while the effect on synaptic plasticity is unclear. Although synaptic proteins that are O-GlcNAcylated are gradually being discovered, the mechanism of how O-GlcNAcylated synaptic protein modulate synaptic transmission has only been reported on CREB, synapsin, and GluA2 subunit of AMPAR. Future research enabling the manipulation of O-GlcNAcylation in individual synaptic proteins should reveal hidden aspects of O-GlcNAcylated synaptic proteins as modulators of synaptic transmission.https://doi.org/10.1186/s13041-023-01072-4O-GlcNAcylationO-GlcNAc transferaseO-GlcNAcaseSynaptic transmissionSynaptic plasticity |
| spellingShingle | Seunghyo Han Jun-Nyeong Kim Chan Ho Park Jin-Seok Byun Do-Yeon Kim Hyoung-Gon Ko Modulation of synaptic transmission through O-GlcNAcylation Molecular Brain O-GlcNAcylation O-GlcNAc transferase O-GlcNAcase Synaptic transmission Synaptic plasticity |
| title | Modulation of synaptic transmission through O-GlcNAcylation |
| title_full | Modulation of synaptic transmission through O-GlcNAcylation |
| title_fullStr | Modulation of synaptic transmission through O-GlcNAcylation |
| title_full_unstemmed | Modulation of synaptic transmission through O-GlcNAcylation |
| title_short | Modulation of synaptic transmission through O-GlcNAcylation |
| title_sort | modulation of synaptic transmission through o glcnacylation |
| topic | O-GlcNAcylation O-GlcNAc transferase O-GlcNAcase Synaptic transmission Synaptic plasticity |
| url | https://doi.org/10.1186/s13041-023-01072-4 |
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