The Enigmatic Nature of the TCR-pMHC Interaction: Implications for CAR-T and TCR-T Engineering

The Enigmatic Nature of the TCR-pMHC Interaction: Implications for CAR-T and TCR-T Engineering

The interaction of the T-cell receptor (TCR) with a peptide in the major histocompatibility complex (pMHC) plays a central role in the adaptive immunity of higher chordates. Due to the high specificity and sensitivity of this process, the immune system quickly recognizes and efficiently responds to...

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Bibliographic Details
Main Authors: D. V. Shevyrev, V. P. Tereshchenko, S. V. Sennikov
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:International Journal of Molecular Sciences
Subjects:
TCR
mechanosensor
pMHC
affinity
CAR-T
TCR-engineering
Online Access:https://www.mdpi.com/1422-0067/23/23/14728

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