PI3K/AKT Signal Pathway: A Target of Natural Products in the Prevention and Treatment of Alzheimer’s Disease and Parkinson’s Disease
Alzheimer’s disease (AD) and Parkinson’s disease (PD) are two typical neurodegenerative diseases that increased with aging. With the emergence of aging population, the health problem and economic burden caused by the two diseases also increase. Phosphatidylinositol 3-kinases/protein kinase B (PI3K/A...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-04-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2021.648636/full |
| _version_ | 1818363467164286976 |
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| author | Hui-Zhi Long Hui-Zhi Long Yan Cheng Yan Cheng Zi-Wei Zhou Zi-Wei Zhou Hong-Yu Luo Hong-Yu Luo Dan-Dan Wen Li-Chen Gao Li-Chen Gao |
| author_facet | Hui-Zhi Long Hui-Zhi Long Yan Cheng Yan Cheng Zi-Wei Zhou Zi-Wei Zhou Hong-Yu Luo Hong-Yu Luo Dan-Dan Wen Li-Chen Gao Li-Chen Gao |
| author_sort | Hui-Zhi Long |
| collection | DOAJ |
| description | Alzheimer’s disease (AD) and Parkinson’s disease (PD) are two typical neurodegenerative diseases that increased with aging. With the emergence of aging population, the health problem and economic burden caused by the two diseases also increase. Phosphatidylinositol 3-kinases/protein kinase B (PI3K/AKT) signaling pathway regulates signal transduction and biological processes such as cell proliferation, apoptosis and metabolism. According to reports, it regulates neurotoxicity and mediates the survival of neurons through different substrates such as forkhead box protein Os (FoxOs), glycogen synthase kinase-3β (GSK-3β), and caspase-9. Accumulating evidences indicate that some natural products can play a neuroprotective role by activating PI3K/AKT pathway, providing an effective resource for the discovery of potential therapeutic drugs. This article reviews the relationship between AKT signaling pathway and AD and PD, and discusses the potential natural products based on the PI3K/AKT signaling pathway to treat two diseases in recent years, hoping to provide guidance and reference for this field. Further development of Chinese herbal medicine is needed to treat these two diseases. |
| first_indexed | 2024-12-13T21:48:56Z |
| format | Article |
| id | doaj.art-f24d2027239e44c491856fffaf804416 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-13T21:48:56Z |
| publishDate | 2021-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-f24d2027239e44c491856fffaf8044162022-12-21T23:30:20ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122021-04-011210.3389/fphar.2021.648636648636PI3K/AKT Signal Pathway: A Target of Natural Products in the Prevention and Treatment of Alzheimer’s Disease and Parkinson’s DiseaseHui-Zhi Long0Hui-Zhi Long1Yan Cheng2Yan Cheng3Zi-Wei Zhou4Zi-Wei Zhou5Hong-Yu Luo6Hong-Yu Luo7Dan-Dan Wen8Li-Chen Gao9Li-Chen Gao10Department of Pharmacy, Cancer Institute, Phase I Clinical Trial Centre, Changsha Central Hospital Affiliated to University of South China, School of Pharmacy, University of South China, Changsha, ChinaHunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, Hengyang, ChinaDepartment of Pharmacy, Cancer Institute, Phase I Clinical Trial Centre, Changsha Central Hospital Affiliated to University of South China, School of Pharmacy, University of South China, Changsha, ChinaHunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, Hengyang, ChinaDepartment of Pharmacy, Cancer Institute, Phase I Clinical Trial Centre, Changsha Central Hospital Affiliated to University of South China, School of Pharmacy, University of South China, Changsha, ChinaHunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, Hengyang, ChinaDepartment of Pharmacy, Cancer Institute, Phase I Clinical Trial Centre, Changsha Central Hospital Affiliated to University of South China, School of Pharmacy, University of South China, Changsha, ChinaHunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, Hengyang, ChinaDepartment of Pharmacy, Cancer Institute, Phase I Clinical Trial Centre, Changsha Central Hospital Affiliated to University of South China, School of Pharmacy, University of South China, Changsha, ChinaDepartment of Pharmacy, Cancer Institute, Phase I Clinical Trial Centre, Changsha Central Hospital Affiliated to University of South China, School of Pharmacy, University of South China, Changsha, ChinaHunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, Hengyang, ChinaAlzheimer’s disease (AD) and Parkinson’s disease (PD) are two typical neurodegenerative diseases that increased with aging. With the emergence of aging population, the health problem and economic burden caused by the two diseases also increase. Phosphatidylinositol 3-kinases/protein kinase B (PI3K/AKT) signaling pathway regulates signal transduction and biological processes such as cell proliferation, apoptosis and metabolism. According to reports, it regulates neurotoxicity and mediates the survival of neurons through different substrates such as forkhead box protein Os (FoxOs), glycogen synthase kinase-3β (GSK-3β), and caspase-9. Accumulating evidences indicate that some natural products can play a neuroprotective role by activating PI3K/AKT pathway, providing an effective resource for the discovery of potential therapeutic drugs. This article reviews the relationship between AKT signaling pathway and AD and PD, and discusses the potential natural products based on the PI3K/AKT signaling pathway to treat two diseases in recent years, hoping to provide guidance and reference for this field. Further development of Chinese herbal medicine is needed to treat these two diseases.https://www.frontiersin.org/articles/10.3389/fphar.2021.648636/fullPI3K/Akt signal pathwayneurodegenerative diseasesAlzheimer’s diseaseParkinson’s diseasenatural productsnerve protection |
| spellingShingle | Hui-Zhi Long Hui-Zhi Long Yan Cheng Yan Cheng Zi-Wei Zhou Zi-Wei Zhou Hong-Yu Luo Hong-Yu Luo Dan-Dan Wen Li-Chen Gao Li-Chen Gao PI3K/AKT Signal Pathway: A Target of Natural Products in the Prevention and Treatment of Alzheimer’s Disease and Parkinson’s Disease Frontiers in Pharmacology PI3K/Akt signal pathway neurodegenerative diseases Alzheimer’s disease Parkinson’s disease natural products nerve protection |
| title | PI3K/AKT Signal Pathway: A Target of Natural Products in the Prevention and Treatment of Alzheimer’s Disease and Parkinson’s Disease |
| title_full | PI3K/AKT Signal Pathway: A Target of Natural Products in the Prevention and Treatment of Alzheimer’s Disease and Parkinson’s Disease |
| title_fullStr | PI3K/AKT Signal Pathway: A Target of Natural Products in the Prevention and Treatment of Alzheimer’s Disease and Parkinson’s Disease |
| title_full_unstemmed | PI3K/AKT Signal Pathway: A Target of Natural Products in the Prevention and Treatment of Alzheimer’s Disease and Parkinson’s Disease |
| title_short | PI3K/AKT Signal Pathway: A Target of Natural Products in the Prevention and Treatment of Alzheimer’s Disease and Parkinson’s Disease |
| title_sort | pi3k akt signal pathway a target of natural products in the prevention and treatment of alzheimer s disease and parkinson s disease |
| topic | PI3K/Akt signal pathway neurodegenerative diseases Alzheimer’s disease Parkinson’s disease natural products nerve protection |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2021.648636/full |
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