PI3K/AKT Signal Pathway: A Target of Natural Products in the Prevention and Treatment of Alzheimer’s Disease and Parkinson’s Disease

PI3K/AKT Signal Pathway: A Target of Natural Products in the Prevention and Treatment of Alzheimer’s Disease and Parkinson’s Disease

Alzheimer’s disease (AD) and Parkinson’s disease (PD) are two typical neurodegenerative diseases that increased with aging. With the emergence of aging population, the health problem and economic burden caused by the two diseases also increase. Phosphatidylinositol 3-kinases/protein kinase B (PI3K/A...

Full description

Bibliographic Details
Main Authors:	Hui-Zhi Long, Yan Cheng, Zi-Wei Zhou, Hong-Yu Luo, Dan-Dan Wen, Li-Chen Gao
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-04-01
Series:	Frontiers in Pharmacology
Subjects:	PI3K/Akt signal pathway neurodegenerative diseases Alzheimer’s disease Parkinson’s disease natural products nerve protection
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2021.648636/full

Similar Items

The Exosome-Mediated PI3K/Akt/mTOR Signaling Pathway in Neurological Diseases
by: Amin Iranpanah, et al.
Published: (2023-03-01)

Roles of the PI3K/AKT/mTOR signalling pathways in neurodegenerative diseases and tumours
by: Fei Xu, et al.
Published: (2020-04-01)

Protective effects and mechanism of puerarin targeting PI3K/Akt signal pathway on neurological diseases
by: Qian Wang, et al.
Published: (2022-10-01)

Cross-Dysregulation of O-GlcNAcylation and PI3K/AKT/mTOR Axis in Human Chronic Diseases
by: Ninon Very, et al.
Published: (2018-10-01)

Vitexin protects dopaminergic neurons in MPTP-induced Parkinson’s disease through PI3K/Akt signaling pathway
by: Hu M, et al.
Published: (2018-03-01)

The PI3K/AKT Pathway and <i>PTEN</i> Gene Are Involved in “Tree-Top Disease” of <i>Lymantria dispar</i>
by: Fengjiao Li, et al.
Published: (2022-01-01)

Marek’s Disease Virus Activates the PI3K/Akt Pathway Through Interaction of Its Protein Meq With the P85 Subunit of PI3K to Promote Viral Replication
by: Huimin Li, et al.
Published: (2018-10-01)

Targeting Akt/CREB/BDNF signaling pathway by ginsenosides in neurodegenerative diseases: A mechanistic approach
by: Seyede Nazanin Zarneshan, et al.
Published: (2022-03-01)

Exploring the potential of treating chronic liver disease targeting the PI3K/Akt pathway and polarization mechanism of macrophages
by: Yaqian Yang, et al.
Published: (2023-06-01)

Role of piRNA biogenesis and its neuronal function in the development of neurodegenerative diseases
by: Kaoru Sato, et al.
Published: (2023-05-01)

Progression of the PI3K/Akt signaling pathway in chronic obstructive pulmonary disease
by: Yanhui Liu, et al.
Published: (2023-09-01)

Shen Qi Wan Ameliorates Learning and Memory Impairment Induced by STZ in AD Rats through PI3K/AKT Pathway
by: Junhao Huang, et al.
Published: (2022-06-01)

D-Mannose Regulates Hepatocyte Lipid Metabolism via PI3K/Akt/mTOR Signaling Pathway and Ameliorates Hepatic Steatosis in Alcoholic Liver Disease
by: Mengyao Hu, et al.
Published: (2022-04-01)

“Olfactory three-needle” acupuncture enhances synaptic function in A𝜷1-42-induced Alzheimer’s disease via activating PI3K/AKT/GSK-3𝜷 signaling pathway
by: Yuan Wang, et al.
Published: (2021-03-01)

PENK inhibits osteosarcoma cell migration by activating the PI3K/Akt signaling pathway
by: Hai-ping Zhang, et al.
Published: (2020-04-01)

The Role of Microglia in Alzheimer’s Disease From the Perspective of Immune Inflammation and Iron Metabolism
by: Hui-Zhi Long, et al.
Published: (2022-06-01)

Isoforsythiaside Attenuates Alzheimer’s Disease via Regulating Mitochondrial Function Through the PI3K/AKT Pathway
by: Chunyue Wang, et al.
Published: (2020-08-01)

AngIV-Analog Dihexa Rescues Cognitive Impairment and Recovers Memory in the APP/PS1 Mouse via the PI3K/AKT Signaling Pathway
by: Xiaojin Sun, et al.
Published: (2021-11-01)

Role of Cholinergic Signaling in Alzheimer’s Disease
by: Zhi-Ru Chen, et al.
Published: (2022-03-01)

Brucein D, a Naturally Occurring Tetracyclic Triterpene Quassinoid, Induces Apoptosis in Pancreatic Cancer through ROS-Associated PI3K/Akt Signaling Pathway
by: Zheng-Quan Lai, et al.
Published: (2017-12-01)

Discovery of an evodiamine derivative for PI3K/AKT/GSK3β pathway activation and AD pathology improvement in mouse models
by: Shuo Pang, et al.
Published: (2023-01-01)

Apolipoprotein D alleviates glucocorticoid-induced osteogenesis suppression in bone marrow mesenchymal stem cells via the PI3K/Akt pathway
by: Rong-Hua Yu, et al.
Published: (2020-08-01)

Transient receptor potential vanilloid type-1 regulates periodontal disease damage via the PI3K/AKT signaling pathway
by: xiaolu xu, et al.
Published: (2022-05-01)

Baicalein alleviates TNF-α-induced apoptosis of human nucleus pulposus cells through PI3K/AKT signaling pathway
by: Yang Liu, et al.
Published: (2023-04-01)

Psoralidin inhibits osteosarcoma growth and metastasis by downregulating ITGB1 expression via the FAK and PI3K/Akt signaling pathways
by: Shengwen Cheng, et al.
Published: (2023-03-01)

Oligo-Porphyran Ameliorates Neurobehavioral Deficits in Parkinsonian Mice by Regulating the PI3K/Akt/Bcl-2 Pathway
by: Yingjuan Liu, et al.
Published: (2018-03-01)

Berberine Induced Apoptosis of Human Osteosarcoma Cells by Inhibiting Phosphoinositide 3 Kinase/Protein Kinase B (PI3K/Akt) Signal Pathway Activation
by: Zhi-Ze CHEN
Published: (2016-05-01)

The Biogenesis and Functions of piRNAs in Human Diseases
by: Xi Wu, et al.
Published: (2020-09-01)

D-Limonene Is a Potential Monoterpene to Inhibit PI3K/Akt/IKK-α/NF-κB p65 Signaling Pathway in Coronavirus Disease 2019 Pulmonary Fibrosis
by: Fan Yang, et al.
Published: (2021-03-01)

Effect of nicastrin on hepatocellular carcinoma proliferation and apoptosis through PI3K/AKT signalling pathway modulation
by: Xicheng Wang, et al.
Published: (2020-03-01)

Curcumin alleviates LPS-induced retinal inflammation by inhibiting PI3k/Akt signaling pathway
by: Yan Li, et al.
Published: (2020-02-01)

Enhancement of Insulin/PI3K/Akt Signaling Pathway and Modulation of Gut Microbiome by Probiotics Fermentation Technology, a Kefir Grain Product, in Sporadic Alzheimer’s Disease Model in Mice
by: Nesrine S. El Sayed, et al.
Published: (2021-07-01)

Network pharmacology reveals that Berberine may function against Alzheimer’s disease via the AKT signaling pathway
by: Wei Wei, et al.
Published: (2023-05-01)

Association of HOTAIR expression with PI3K/Akt pathway activation in adenocarcinoma of esophagogastric junction
by: Hui Zhang, et al.
Published: (2016-01-01)

Glutamine protects against oxidative stress injury through inhibiting the activation of PI3K/Akt signaling pathway in parkinsonian cell model
by: Yingqian Zhao, et al.
Published: (2019-01-01)

Apatinib potentiates irradiation effect via suppressing PI3K/AKT signaling pathway in hepatocellular carcinoma
by: Junbin Liao, et al.
Published: (2019-11-01)

PI3K/AKT/mTOR-Targeted Therapy for Breast Cancer
by: Kunrui Zhu, et al.
Published: (2022-08-01)

Effect of platelet-rich plasma on implant bone defects in rabbits through the FAK/PI3K/AKT signaling pathway
by: Liu Wei, et al.
Published: (2019-07-01)

Implications of PI3K/AKT/PTEN Signaling on Superoxide Dismutases Expression and in the Pathogenesis of Alzheimer’s Disease
by: Satoru Matsuda, et al.
Published: (2018-04-01)

Regulation of ferroptosis by PI3K/Akt signaling pathway: a promising therapeutic axis in cancer
by: Hua Su, et al.
Published: (2024-03-01)