Circulating Reactive Oxygen Species in Adults with Congenital Heart Disease
Oxidative stress is an important pathophysiological mechanism in the development of numerous cardiovascular disorders, but few studies have examined the levels of oxidative stress in adults with congenital heart disease (CHD). The objective of this study was to investigate oxidative stress levels in...
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| Format: | Article |
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MDPI AG
2022-11-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/11/12/2369 |
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| author | Inne Vanreusel Dorien Vermeulen Inge Goovaerts Tibor Stoop Bert Ectors Jacky Cornelis Wendy Hens Erwin de Bliek Hilde Heuten Emeline M. Van Craenenbroeck An Van Berendoncks Vincent F. M. Segers Jacob J. Briedé |
| author_facet | Inne Vanreusel Dorien Vermeulen Inge Goovaerts Tibor Stoop Bert Ectors Jacky Cornelis Wendy Hens Erwin de Bliek Hilde Heuten Emeline M. Van Craenenbroeck An Van Berendoncks Vincent F. M. Segers Jacob J. Briedé |
| author_sort | Inne Vanreusel |
| collection | DOAJ |
| description | Oxidative stress is an important pathophysiological mechanism in the development of numerous cardiovascular disorders, but few studies have examined the levels of oxidative stress in adults with congenital heart disease (CHD). The objective of this study was to investigate oxidative stress levels in adults with CHD and the association with inflammation, exercise capacity and endothelial function. To this end, 36 adults with different types of CHD and 36 age- and gender-matched healthy controls were enrolled. Blood cell counts, hs-CRP, NT-proBNP, fasting glucose, cholesterol levels, iron saturation and folic acid concentrations were determined in venous blood samples. Levels of superoxide anion radical in whole blood were determined using electron paramagnetic resonance spectroscopy in combination with the spin probe CMH. Physical activity was assessed with the IPAQ-SF questionnaire. Vascular function assessment (EndoPAT) and cardiopulmonary exercise testing were performed in the patient group. Superoxide anion radical levels were not statistically significantly different between adults with CHD and the matched controls. Moreover, oxidative stress did not correlate with inflammation, or with endothelial function or cardiorespiratory fitness in CHD; however, a significant negative correlation with iron saturation was observed. Overall, whole blood superoxide anion radical levels in adults with CHD were not elevated, but iron levels seem to play a more important role in oxidative stress mechanisms in CHD than in healthy controls. More research will be needed to improve our understanding of the underlying pathophysiology of CHD. |
| first_indexed | 2024-03-09T17:24:33Z |
| format | Article |
| id | doaj.art-f24fa28397fa4430a47acffef9c790a7 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-09T17:24:33Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-f24fa28397fa4430a47acffef9c790a72023-11-24T12:56:51ZengMDPI AGAntioxidants2076-39212022-11-011112236910.3390/antiox11122369Circulating Reactive Oxygen Species in Adults with Congenital Heart DiseaseInne Vanreusel0Dorien Vermeulen1Inge Goovaerts2Tibor Stoop3Bert Ectors4Jacky Cornelis5Wendy Hens6Erwin de Bliek7Hilde Heuten8Emeline M. Van Craenenbroeck9An Van Berendoncks10Vincent F. M. Segers11Jacob J. Briedé12Department of Cardiology, Antwerp University Hospital, 2650 Edegem, BelgiumDepartment of Cardiology, Antwerp University Hospital, 2650 Edegem, BelgiumDepartment of Cardiology, Antwerp University Hospital, 2650 Edegem, BelgiumDepartment of Cardiology, Antwerp University Hospital, 2650 Edegem, BelgiumDepartment of Cardiology, Antwerp University Hospital, 2650 Edegem, BelgiumDepartment of Cardiology, Antwerp University Hospital, 2650 Edegem, BelgiumDepartment of Cardiology, Antwerp University Hospital, 2650 Edegem, BelgiumDepartment of Cardiology, Antwerp University Hospital, 2650 Edegem, BelgiumDepartment of Cardiology, Antwerp University Hospital, 2650 Edegem, BelgiumDepartment of Cardiology, Antwerp University Hospital, 2650 Edegem, BelgiumDepartment of Cardiology, Antwerp University Hospital, 2650 Edegem, BelgiumDepartment of Cardiology, Antwerp University Hospital, 2650 Edegem, BelgiumDepartment of Toxicogenomics, School of Oncology and Developmental Biology (GROW), Maastricht University, 6211 MD Maastricht, The NetherlandsOxidative stress is an important pathophysiological mechanism in the development of numerous cardiovascular disorders, but few studies have examined the levels of oxidative stress in adults with congenital heart disease (CHD). The objective of this study was to investigate oxidative stress levels in adults with CHD and the association with inflammation, exercise capacity and endothelial function. To this end, 36 adults with different types of CHD and 36 age- and gender-matched healthy controls were enrolled. Blood cell counts, hs-CRP, NT-proBNP, fasting glucose, cholesterol levels, iron saturation and folic acid concentrations were determined in venous blood samples. Levels of superoxide anion radical in whole blood were determined using electron paramagnetic resonance spectroscopy in combination with the spin probe CMH. Physical activity was assessed with the IPAQ-SF questionnaire. Vascular function assessment (EndoPAT) and cardiopulmonary exercise testing were performed in the patient group. Superoxide anion radical levels were not statistically significantly different between adults with CHD and the matched controls. Moreover, oxidative stress did not correlate with inflammation, or with endothelial function or cardiorespiratory fitness in CHD; however, a significant negative correlation with iron saturation was observed. Overall, whole blood superoxide anion radical levels in adults with CHD were not elevated, but iron levels seem to play a more important role in oxidative stress mechanisms in CHD than in healthy controls. More research will be needed to improve our understanding of the underlying pathophysiology of CHD.https://www.mdpi.com/2076-3921/11/12/2369oxidative stressreactive oxygen species (ROS)superoxide anion radicalinflammationexercise capacityendothelial (dys)function |
| spellingShingle | Inne Vanreusel Dorien Vermeulen Inge Goovaerts Tibor Stoop Bert Ectors Jacky Cornelis Wendy Hens Erwin de Bliek Hilde Heuten Emeline M. Van Craenenbroeck An Van Berendoncks Vincent F. M. Segers Jacob J. Briedé Circulating Reactive Oxygen Species in Adults with Congenital Heart Disease Antioxidants oxidative stress reactive oxygen species (ROS) superoxide anion radical inflammation exercise capacity endothelial (dys)function |
| title | Circulating Reactive Oxygen Species in Adults with Congenital Heart Disease |
| title_full | Circulating Reactive Oxygen Species in Adults with Congenital Heart Disease |
| title_fullStr | Circulating Reactive Oxygen Species in Adults with Congenital Heart Disease |
| title_full_unstemmed | Circulating Reactive Oxygen Species in Adults with Congenital Heart Disease |
| title_short | Circulating Reactive Oxygen Species in Adults with Congenital Heart Disease |
| title_sort | circulating reactive oxygen species in adults with congenital heart disease |
| topic | oxidative stress reactive oxygen species (ROS) superoxide anion radical inflammation exercise capacity endothelial (dys)function |
| url | https://www.mdpi.com/2076-3921/11/12/2369 |
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