Association between HOMA-IR and ovarian sensitivity index in women with PCOS undergoing ART: A retrospective cohort study
IntroductionInsulin resistance (IR) may play a central role in the pathophysiology of polycystic ovary syndrome (PCOS). Controlled ovarian stimulation (COS) in PCOS women in the setting of assisted reproductive technology (ART) is always a challenge for clinicians. However, it remains unclear whethe...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1117996/full |
| _version_ | 1811157847730290688 |
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| author | Yan Li Yiwen Wang Hai Liu Shaodi Zhang Cuilian Zhang |
| author_facet | Yan Li Yiwen Wang Hai Liu Shaodi Zhang Cuilian Zhang |
| author_sort | Yan Li |
| collection | DOAJ |
| description | IntroductionInsulin resistance (IR) may play a central role in the pathophysiology of polycystic ovary syndrome (PCOS). Controlled ovarian stimulation (COS) in PCOS women in the setting of assisted reproductive technology (ART) is always a challenge for clinicians. However, it remains unclear whether IR in women with PCOS correlates with reduced ovarian sensitivity to exogenous gonadotropin (Gn). This study aimed to explore the association between homeostasis model assessment of insulin resistance (HOMA-IR) and ovarian sensitivity index (OSI).MethodsIn this retrospective cohort study, we explored the association between Ln HOMA-IR and Ln OSI based on smoothing splines generated by generalized additive model (GAM). Then the correlation between HOMA-IR and OSI was further tested with a multivariable linear regression model and subgroup analysis.Results1508 women with PCOS aged 20-39 years undergoing their first oocyte retrieval cycle were included consecutively between 2018 until 2022. We observed a negative association between Ln HOMA-IR and Ln OSI by using smoothing splines. In multivariable linear regression analysis, the inverse association between Ln HOMA-IR and Ln OSI was still found in PCOS women after adjustment for potential confounders (β = -0.18, 95% CI -0.25, -0.11). Compared with patients with the lowest tertile of HOMA-IR, those who had the highest tertile of HOMA-IR had lower OSI values (β = -0.25, 95% CI -0.36, -0.15).DiscussionOur study provided evidence for the inverse correlation between IR and the ovarian sensitivity during COS in PCOS women. Herein, we proposed new insights for individualized manipulation in PCOS patients with IR undergoing ART. |
| first_indexed | 2024-04-10T05:13:15Z |
| format | Article |
| id | doaj.art-f250392517f640438c8da716a60576d2 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-10T05:13:15Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-f250392517f640438c8da716a60576d22023-03-09T06:15:12ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-03-011410.3389/fendo.2023.11179961117996Association between HOMA-IR and ovarian sensitivity index in women with PCOS undergoing ART: A retrospective cohort studyYan Li0Yiwen Wang1Hai Liu2Shaodi Zhang3Cuilian Zhang4Reproductive Medicine Center, People’s Hospital of Zhengzhou University, Henan Provincial People’s Hospital, Zhengzhou, Henan, ChinaReproductive Medicine Center, People’s Hospital of Zhengzhou University, Henan Provincial People’s Hospital, Zhengzhou, Henan, ChinaDepartment of Gynaecology and Obstetrics, Xinjiang Production and Construction Corps 13 Division Red Star Hospital, Hami, Xinjiang, ChinaReproductive Medicine Center, People’s Hospital of Zhengzhou University, Henan Provincial People’s Hospital, Zhengzhou, Henan, ChinaReproductive Medicine Center, People’s Hospital of Zhengzhou University, Henan Provincial People’s Hospital, Zhengzhou, Henan, ChinaIntroductionInsulin resistance (IR) may play a central role in the pathophysiology of polycystic ovary syndrome (PCOS). Controlled ovarian stimulation (COS) in PCOS women in the setting of assisted reproductive technology (ART) is always a challenge for clinicians. However, it remains unclear whether IR in women with PCOS correlates with reduced ovarian sensitivity to exogenous gonadotropin (Gn). This study aimed to explore the association between homeostasis model assessment of insulin resistance (HOMA-IR) and ovarian sensitivity index (OSI).MethodsIn this retrospective cohort study, we explored the association between Ln HOMA-IR and Ln OSI based on smoothing splines generated by generalized additive model (GAM). Then the correlation between HOMA-IR and OSI was further tested with a multivariable linear regression model and subgroup analysis.Results1508 women with PCOS aged 20-39 years undergoing their first oocyte retrieval cycle were included consecutively between 2018 until 2022. We observed a negative association between Ln HOMA-IR and Ln OSI by using smoothing splines. In multivariable linear regression analysis, the inverse association between Ln HOMA-IR and Ln OSI was still found in PCOS women after adjustment for potential confounders (β = -0.18, 95% CI -0.25, -0.11). Compared with patients with the lowest tertile of HOMA-IR, those who had the highest tertile of HOMA-IR had lower OSI values (β = -0.25, 95% CI -0.36, -0.15).DiscussionOur study provided evidence for the inverse correlation between IR and the ovarian sensitivity during COS in PCOS women. Herein, we proposed new insights for individualized manipulation in PCOS patients with IR undergoing ART.https://www.frontiersin.org/articles/10.3389/fendo.2023.1117996/fullinsulin resistanceovarian sensitivityOSIHOMA-IRART |
| spellingShingle | Yan Li Yiwen Wang Hai Liu Shaodi Zhang Cuilian Zhang Association between HOMA-IR and ovarian sensitivity index in women with PCOS undergoing ART: A retrospective cohort study Frontiers in Endocrinology insulin resistance ovarian sensitivity OSI HOMA-IR ART |
| title | Association between HOMA-IR and ovarian sensitivity index in women with PCOS undergoing ART: A retrospective cohort study |
| title_full | Association between HOMA-IR and ovarian sensitivity index in women with PCOS undergoing ART: A retrospective cohort study |
| title_fullStr | Association between HOMA-IR and ovarian sensitivity index in women with PCOS undergoing ART: A retrospective cohort study |
| title_full_unstemmed | Association between HOMA-IR and ovarian sensitivity index in women with PCOS undergoing ART: A retrospective cohort study |
| title_short | Association between HOMA-IR and ovarian sensitivity index in women with PCOS undergoing ART: A retrospective cohort study |
| title_sort | association between homa ir and ovarian sensitivity index in women with pcos undergoing art a retrospective cohort study |
| topic | insulin resistance ovarian sensitivity OSI HOMA-IR ART |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1117996/full |
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