The role of histone deacetylases in human gastrointestinal and associated glands cancer
Background & Objective: In the eukaryotic cells, the DNA wraps around the histone proteins (H2A, H2B, H3, and H4) and constitutes the nucleosome. Chromatin organization plays a major role in the control of gene expression. Epigenetic modifications can induce a reversible change in the chromatin...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Fasa University of Medical Sciences
2019-09-01
|
| Series: | Journal of Advanced Biomedical Sciences |
| Subjects: | |
| Online Access: | http://jabs.fums.ac.ir/article-1-1910-en.pdf |
| _version_ | 1827812409579929600 |
|---|---|
| author | Masumeh Sanaei Fraidoon Kavoosi |
| author_facet | Masumeh Sanaei Fraidoon Kavoosi |
| author_sort | Masumeh Sanaei |
| collection | DOAJ |
| description | Background & Objective: In the eukaryotic cells, the DNA wraps around the histone proteins (H2A, H2B, H3, and H4) and constitutes the nucleosome. Chromatin organization plays a major role in the control of gene expression. Epigenetic modifications can induce a reversible change in the chromatin structure as being open and accessible DNA to the transcriptional factors resulting in gene expression. Histone modification, as an epigenetic factor, is necessary for gene expression. These modifications are concluded in a balance between histone acetyltransferase and histone deacetylase activity. Histone deacetylation compacts chromatin structure resulting in gene silencing. Tumor suppressor genes play an important role in the cancer prevention. Deacetylation of these genes resulting in genes silencing and carcinogenesis. In this review, we will evaluate the effects of histone deacetylases on the gastroinetestinal tract and associated glands cancer.
Methods: For this review article, we search different online sources by various researcher motors including Scopus, PubMed, and ISI resulted in finding articles correlated with the effect of histone deacetylase on the gastroinetestinal tract and associated glands cancer.
Conclusions: In the current study, we concluded that histone deacetylases can induce cancer by histone deacetylation of tumor suppressor genes in the gastrointestinal tract and associated glands. |
| first_indexed | 2024-03-11T23:17:05Z |
| format | Article |
| id | doaj.art-f2542e0f5bda47c79aabd70b6697c3b1 |
| institution | Directory Open Access Journal |
| issn | 2228-5105 2783-1523 |
| language | English |
| last_indexed | 2024-03-11T23:17:05Z |
| publishDate | 2019-09-01 |
| publisher | Fasa University of Medical Sciences |
| record_format | Article |
| series | Journal of Advanced Biomedical Sciences |
| spelling | doaj.art-f2542e0f5bda47c79aabd70b6697c3b12023-09-20T21:26:39ZengFasa University of Medical SciencesJournal of Advanced Biomedical Sciences2228-51052783-15232019-09-019315341541The role of histone deacetylases in human gastrointestinal and associated glands cancerMasumeh Sanaei0Fraidoon Kavoosi1 Research center for non-communicable diseases, Jahrom University of medical sciences, Jahrom, Iran Research center for non-communicable diseases, Jahrom University of medical sciences, Jahrom, Iran Background & Objective: In the eukaryotic cells, the DNA wraps around the histone proteins (H2A, H2B, H3, and H4) and constitutes the nucleosome. Chromatin organization plays a major role in the control of gene expression. Epigenetic modifications can induce a reversible change in the chromatin structure as being open and accessible DNA to the transcriptional factors resulting in gene expression. Histone modification, as an epigenetic factor, is necessary for gene expression. These modifications are concluded in a balance between histone acetyltransferase and histone deacetylase activity. Histone deacetylation compacts chromatin structure resulting in gene silencing. Tumor suppressor genes play an important role in the cancer prevention. Deacetylation of these genes resulting in genes silencing and carcinogenesis. In this review, we will evaluate the effects of histone deacetylases on the gastroinetestinal tract and associated glands cancer. Methods: For this review article, we search different online sources by various researcher motors including Scopus, PubMed, and ISI resulted in finding articles correlated with the effect of histone deacetylase on the gastroinetestinal tract and associated glands cancer. Conclusions: In the current study, we concluded that histone deacetylases can induce cancer by histone deacetylation of tumor suppressor genes in the gastrointestinal tract and associated glands.http://jabs.fums.ac.ir/article-1-1910-en.pdfhistone deacetylasestumor suppressor genescancer |
| spellingShingle | Masumeh Sanaei Fraidoon Kavoosi The role of histone deacetylases in human gastrointestinal and associated glands cancer Journal of Advanced Biomedical Sciences histone deacetylases tumor suppressor genes cancer |
| title | The role of histone deacetylases in human gastrointestinal and associated glands cancer |
| title_full | The role of histone deacetylases in human gastrointestinal and associated glands cancer |
| title_fullStr | The role of histone deacetylases in human gastrointestinal and associated glands cancer |
| title_full_unstemmed | The role of histone deacetylases in human gastrointestinal and associated glands cancer |
| title_short | The role of histone deacetylases in human gastrointestinal and associated glands cancer |
| title_sort | role of histone deacetylases in human gastrointestinal and associated glands cancer |
| topic | histone deacetylases tumor suppressor genes cancer |
| url | http://jabs.fums.ac.ir/article-1-1910-en.pdf |
| work_keys_str_mv | AT masumehsanaei theroleofhistonedeacetylasesinhumangastrointestinalandassociatedglandscancer AT fraidoonkavoosi theroleofhistonedeacetylasesinhumangastrointestinalandassociatedglandscancer AT masumehsanaei roleofhistonedeacetylasesinhumangastrointestinalandassociatedglandscancer AT fraidoonkavoosi roleofhistonedeacetylasesinhumangastrointestinalandassociatedglandscancer |