Ikzf2 Regulates the Development of ICOS+ Th Cells to Mediate Immune Response in the Spleen of S. japonicum-Infected C57BL/6 Mice

Ikzf2 Regulates the Development of ICOS+ Th Cells to Mediate Immune Response in the Spleen of S. japonicum-Infected C57BL/6 Mice

BackgroundTh cells (helper T cells) have multiple functions in Schistosoma japonicum (S. japonicum) infection. Inducible co-stimulator (ICOS) is induced and expressed in activated T lymphocytes, which enhances the development of B cells and antibody production through the ICOS/ICOSL pathway. It rema...

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Bibliographic Details
Main Authors: Shihao Xie, Haixia Wei, Anping Peng, Anqi Xie, Jiajie Li, Chao Fang, Feihu Shi, Quan Yang, He Huang, Hongyan Xie, Xingfei Pan, Xu Tian, Jun Huang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Immunology
Subjects:
Schistosoma japonicum
spleen
CD4+ T cells
ICOS
Ikzf2(Helios)
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.687919/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.687919/full

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