A Non-Enzymatic Sensor Based on Fc-CHIT/CNT@Cu Nanohybrids for Electrochemical Detection of Glucose
Herein, a composite structure, consisting of Cu nanoparticles (NPs) deposited onto carbon nanotubes and modified with ferrocene-branched chitosan, was prepared in order to develop a nonenzymatic electrochemical glucose biosensor ferrocene-chitosan/carbon nanotube@ Cu (Fc-CHIT/CNT@Cu). The elemental...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-10-01
|
| Series: | Polymers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4360/12/10/2419 |
| _version_ | 1797550424830509056 |
|---|---|
| author | Fang Wang Sheng Hu Fengna Shi Kexin Huang Jiarui Li |
| author_facet | Fang Wang Sheng Hu Fengna Shi Kexin Huang Jiarui Li |
| author_sort | Fang Wang |
| collection | DOAJ |
| description | Herein, a composite structure, consisting of Cu nanoparticles (NPs) deposited onto carbon nanotubes and modified with ferrocene-branched chitosan, was prepared in order to develop a nonenzymatic electrochemical glucose biosensor ferrocene-chitosan/carbon nanotube@ Cu (Fc-CHIT/CNT@Cu). The elemental composition of the carbon nanohybrids, morphology and structure were characterized by various techniques. Electrochemical impedance spectroscopy (EIS) was used to study the interfacial properties of the electrodes. Cyclic voltammetry (CV) and chronoamperometry methods in alkaline solution were used to determine glucose biosensing properties. The synergy effect of Cu NPs and Fc on current responses of the developed electrode resulted in good glucose sensitivity, including broad linear detection between 0.2 mM and 22 mM, a low detection limit of 13.52 μM and sensitivity of 1.256 μA mM<sup>−1</sup>cm<sup>−2</sup>. Moreover, the modified electrode possessed long-term stability and good selectivity in the presence of ascorbic acid, dopamine and uric acid. The results indicated that this inexpensive electrode had potential application for non-enzymatic electrochemical glucose detection. |
| first_indexed | 2024-03-10T15:29:05Z |
| format | Article |
| id | doaj.art-f254f2dd7d59401b8932c15fabdb2e2e |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-10T15:29:05Z |
| publishDate | 2020-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-f254f2dd7d59401b8932c15fabdb2e2e2023-11-20T17:50:28ZengMDPI AGPolymers2073-43602020-10-011210241910.3390/polym12102419A Non-Enzymatic Sensor Based on Fc-CHIT/CNT@Cu Nanohybrids for Electrochemical Detection of GlucoseFang Wang0Sheng Hu1Fengna Shi2Kexin Huang3Jiarui Li4Nanjing Forestry Univ, Coll Chem Engn, Nanjing 210037, Jiangsu, ChinaNanjing Forestry Univ, Coll Chem Engn, Nanjing 210037, Jiangsu, ChinaNanjing Forestry Univ, Coll Chem Engn, Nanjing 210037, Jiangsu, ChinaNanjing Forestry Univ, Coll Chem Engn, Nanjing 210037, Jiangsu, ChinaNanjing Forestry Univ, Coll Chem Engn, Nanjing 210037, Jiangsu, ChinaHerein, a composite structure, consisting of Cu nanoparticles (NPs) deposited onto carbon nanotubes and modified with ferrocene-branched chitosan, was prepared in order to develop a nonenzymatic electrochemical glucose biosensor ferrocene-chitosan/carbon nanotube@ Cu (Fc-CHIT/CNT@Cu). The elemental composition of the carbon nanohybrids, morphology and structure were characterized by various techniques. Electrochemical impedance spectroscopy (EIS) was used to study the interfacial properties of the electrodes. Cyclic voltammetry (CV) and chronoamperometry methods in alkaline solution were used to determine glucose biosensing properties. The synergy effect of Cu NPs and Fc on current responses of the developed electrode resulted in good glucose sensitivity, including broad linear detection between 0.2 mM and 22 mM, a low detection limit of 13.52 μM and sensitivity of 1.256 μA mM<sup>−1</sup>cm<sup>−2</sup>. Moreover, the modified electrode possessed long-term stability and good selectivity in the presence of ascorbic acid, dopamine and uric acid. The results indicated that this inexpensive electrode had potential application for non-enzymatic electrochemical glucose detection.https://www.mdpi.com/2073-4360/12/10/2419carbon nanotubechitosancopper nanoparticlesferroceneelectrochemical sensorglucose |
| spellingShingle | Fang Wang Sheng Hu Fengna Shi Kexin Huang Jiarui Li A Non-Enzymatic Sensor Based on Fc-CHIT/CNT@Cu Nanohybrids for Electrochemical Detection of Glucose Polymers carbon nanotube chitosan copper nanoparticles ferrocene electrochemical sensor glucose |
| title | A Non-Enzymatic Sensor Based on Fc-CHIT/CNT@Cu Nanohybrids for Electrochemical Detection of Glucose |
| title_full | A Non-Enzymatic Sensor Based on Fc-CHIT/CNT@Cu Nanohybrids for Electrochemical Detection of Glucose |
| title_fullStr | A Non-Enzymatic Sensor Based on Fc-CHIT/CNT@Cu Nanohybrids for Electrochemical Detection of Glucose |
| title_full_unstemmed | A Non-Enzymatic Sensor Based on Fc-CHIT/CNT@Cu Nanohybrids for Electrochemical Detection of Glucose |
| title_short | A Non-Enzymatic Sensor Based on Fc-CHIT/CNT@Cu Nanohybrids for Electrochemical Detection of Glucose |
| title_sort | non enzymatic sensor based on fc chit cnt cu nanohybrids for electrochemical detection of glucose |
| topic | carbon nanotube chitosan copper nanoparticles ferrocene electrochemical sensor glucose |
| url | https://www.mdpi.com/2073-4360/12/10/2419 |
| work_keys_str_mv | AT fangwang anonenzymaticsensorbasedonfcchitcntcunanohybridsforelectrochemicaldetectionofglucose AT shenghu anonenzymaticsensorbasedonfcchitcntcunanohybridsforelectrochemicaldetectionofglucose AT fengnashi anonenzymaticsensorbasedonfcchitcntcunanohybridsforelectrochemicaldetectionofglucose AT kexinhuang anonenzymaticsensorbasedonfcchitcntcunanohybridsforelectrochemicaldetectionofglucose AT jiaruili anonenzymaticsensorbasedonfcchitcntcunanohybridsforelectrochemicaldetectionofglucose AT fangwang nonenzymaticsensorbasedonfcchitcntcunanohybridsforelectrochemicaldetectionofglucose AT shenghu nonenzymaticsensorbasedonfcchitcntcunanohybridsforelectrochemicaldetectionofglucose AT fengnashi nonenzymaticsensorbasedonfcchitcntcunanohybridsforelectrochemicaldetectionofglucose AT kexinhuang nonenzymaticsensorbasedonfcchitcntcunanohybridsforelectrochemicaldetectionofglucose AT jiaruili nonenzymaticsensorbasedonfcchitcntcunanohybridsforelectrochemicaldetectionofglucose |