Emerging Anti-Fouling Methods: Towards Reusability of 3D-Printed Devices for Biomedical Applications
Microfluidic devices are used in a myriad of biomedical applications such as cancer screening, drug testing, and point-of-care diagnostics. Three-dimensional (3D) printing offers a low-cost, rapid prototyping, efficient fabrication method, as compared to the costly—in terms of time, labor,...
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-04-01
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| Series: | Micromachines |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2072-666X/9/4/196 |
| _version_ | 1811204603541192704 |
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| author | Eric Lepowsky Savas Tasoglu |
| author_facet | Eric Lepowsky Savas Tasoglu |
| author_sort | Eric Lepowsky |
| collection | DOAJ |
| description | Microfluidic devices are used in a myriad of biomedical applications such as cancer screening, drug testing, and point-of-care diagnostics. Three-dimensional (3D) printing offers a low-cost, rapid prototyping, efficient fabrication method, as compared to the costly—in terms of time, labor, and resources—traditional fabrication method of soft lithography of poly(dimethylsiloxane) (PDMS). Various 3D printing methods are applicable, including fused deposition modeling, stereolithography, and photopolymer inkjet printing. Additionally, several materials are available that have low-viscosity in their raw form and, after printing and curing, exhibit high material strength, optical transparency, and biocompatibility. These features make 3D-printed microfluidic chips ideal for biomedical applications. However, for developing devices capable of long-term use, fouling—by nonspecific protein absorption and bacterial adhesion due to the intrinsic hydrophobicity of most 3D-printed materials—presents a barrier to reusability. For this reason, there is a growing interest in anti-fouling methods and materials. Traditional and emerging approaches to anti-fouling are presented in regard to their applicability to microfluidic chips, with a particular interest in approaches compatible with 3D-printed chips. |
| first_indexed | 2024-04-12T03:16:57Z |
| format | Article |
| id | doaj.art-f25583919e684fb78efad2c6e00cf1bf |
| institution | Directory Open Access Journal |
| issn | 2072-666X |
| language | English |
| last_indexed | 2024-04-12T03:16:57Z |
| publishDate | 2018-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Micromachines |
| spelling | doaj.art-f25583919e684fb78efad2c6e00cf1bf2022-12-22T03:50:06ZengMDPI AGMicromachines2072-666X2018-04-019419610.3390/mi9040196mi9040196Emerging Anti-Fouling Methods: Towards Reusability of 3D-Printed Devices for Biomedical ApplicationsEric Lepowsky0Savas Tasoglu1Department of Mechanical Engineering, University of Connecticut, Storrs, CT 06269, USADepartment of Mechanical Engineering, University of Connecticut, Storrs, CT 06269, USAMicrofluidic devices are used in a myriad of biomedical applications such as cancer screening, drug testing, and point-of-care diagnostics. Three-dimensional (3D) printing offers a low-cost, rapid prototyping, efficient fabrication method, as compared to the costly—in terms of time, labor, and resources—traditional fabrication method of soft lithography of poly(dimethylsiloxane) (PDMS). Various 3D printing methods are applicable, including fused deposition modeling, stereolithography, and photopolymer inkjet printing. Additionally, several materials are available that have low-viscosity in their raw form and, after printing and curing, exhibit high material strength, optical transparency, and biocompatibility. These features make 3D-printed microfluidic chips ideal for biomedical applications. However, for developing devices capable of long-term use, fouling—by nonspecific protein absorption and bacterial adhesion due to the intrinsic hydrophobicity of most 3D-printed materials—presents a barrier to reusability. For this reason, there is a growing interest in anti-fouling methods and materials. Traditional and emerging approaches to anti-fouling are presented in regard to their applicability to microfluidic chips, with a particular interest in approaches compatible with 3D-printed chips.http://www.mdpi.com/2072-666X/9/4/1963D printingmicrofluidic chipsanti-foulingsurface coatings |
| spellingShingle | Eric Lepowsky Savas Tasoglu Emerging Anti-Fouling Methods: Towards Reusability of 3D-Printed Devices for Biomedical Applications Micromachines 3D printing microfluidic chips anti-fouling surface coatings |
| title | Emerging Anti-Fouling Methods: Towards Reusability of 3D-Printed Devices for Biomedical Applications |
| title_full | Emerging Anti-Fouling Methods: Towards Reusability of 3D-Printed Devices for Biomedical Applications |
| title_fullStr | Emerging Anti-Fouling Methods: Towards Reusability of 3D-Printed Devices for Biomedical Applications |
| title_full_unstemmed | Emerging Anti-Fouling Methods: Towards Reusability of 3D-Printed Devices for Biomedical Applications |
| title_short | Emerging Anti-Fouling Methods: Towards Reusability of 3D-Printed Devices for Biomedical Applications |
| title_sort | emerging anti fouling methods towards reusability of 3d printed devices for biomedical applications |
| topic | 3D printing microfluidic chips anti-fouling surface coatings |
| url | http://www.mdpi.com/2072-666X/9/4/196 |
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