Dendritic Cells: The Long and Evolving Road towards Successful Targetability in Cancer
Dendritic cells (DCs) are a unique myeloid cell lineage that play a central role in the priming of the adaptive immune response. As such, they are an attractive target for immune oncology based therapeutic approaches. However, targeting these cells has proven challenging with many studies proving in...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-09-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/11/19/3028 |
| _version_ | 1827654826232643584 |
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| author | Enrica Marmonti Jacqueline Oliva-Ramirez Cara Haymaker |
| author_facet | Enrica Marmonti Jacqueline Oliva-Ramirez Cara Haymaker |
| author_sort | Enrica Marmonti |
| collection | DOAJ |
| description | Dendritic cells (DCs) are a unique myeloid cell lineage that play a central role in the priming of the adaptive immune response. As such, they are an attractive target for immune oncology based therapeutic approaches. However, targeting these cells has proven challenging with many studies proving inconclusive or of no benefit in a clinical trial setting. In this review, we highlight the known and unknown about this rare but powerful immune cell. As technologies have expanded our understanding of the complexity of DC development, subsets and response features, we are now left to apply this knowledge to the design of new therapeutic strategies in cancer. We propose that utilization of these technologies through a multiomics approach will allow for an improved directed targeting of DCs in a clinical trial setting. In addition, the DC research community should consider a consensus on subset nomenclature to distinguish new subsets from functional or phenotypic changes in response to their environment. |
| first_indexed | 2024-03-09T21:54:19Z |
| format | Article |
| id | doaj.art-f255ba65e4a74d349f83c24206f9e9b3 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-09T21:54:19Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-f255ba65e4a74d349f83c24206f9e9b32023-11-23T20:01:26ZengMDPI AGCells2073-44092022-09-011119302810.3390/cells11193028Dendritic Cells: The Long and Evolving Road towards Successful Targetability in CancerEnrica Marmonti0Jacqueline Oliva-Ramirez1Cara Haymaker2Department of Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USADepartment of Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USADepartment of Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USADendritic cells (DCs) are a unique myeloid cell lineage that play a central role in the priming of the adaptive immune response. As such, they are an attractive target for immune oncology based therapeutic approaches. However, targeting these cells has proven challenging with many studies proving inconclusive or of no benefit in a clinical trial setting. In this review, we highlight the known and unknown about this rare but powerful immune cell. As technologies have expanded our understanding of the complexity of DC development, subsets and response features, we are now left to apply this knowledge to the design of new therapeutic strategies in cancer. We propose that utilization of these technologies through a multiomics approach will allow for an improved directed targeting of DCs in a clinical trial setting. In addition, the DC research community should consider a consensus on subset nomenclature to distinguish new subsets from functional or phenotypic changes in response to their environment.https://www.mdpi.com/2073-4409/11/19/3028antigen-presenting cellsdendritic cellsmonocytesimmunotherapycancer |
| spellingShingle | Enrica Marmonti Jacqueline Oliva-Ramirez Cara Haymaker Dendritic Cells: The Long and Evolving Road towards Successful Targetability in Cancer Cells antigen-presenting cells dendritic cells monocytes immunotherapy cancer |
| title | Dendritic Cells: The Long and Evolving Road towards Successful Targetability in Cancer |
| title_full | Dendritic Cells: The Long and Evolving Road towards Successful Targetability in Cancer |
| title_fullStr | Dendritic Cells: The Long and Evolving Road towards Successful Targetability in Cancer |
| title_full_unstemmed | Dendritic Cells: The Long and Evolving Road towards Successful Targetability in Cancer |
| title_short | Dendritic Cells: The Long and Evolving Road towards Successful Targetability in Cancer |
| title_sort | dendritic cells the long and evolving road towards successful targetability in cancer |
| topic | antigen-presenting cells dendritic cells monocytes immunotherapy cancer |
| url | https://www.mdpi.com/2073-4409/11/19/3028 |
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