Cerebral Insulin Bolus Revokes the Changes in Hepatic Lipid Metabolism Induced by Chronic Central Leptin Infusion

Cerebral Insulin Bolus Revokes the Changes in Hepatic Lipid Metabolism Induced by Chronic Central Leptin Infusion

Central actions of leptin and insulin on hepatic lipid metabolism can be opposing and the mechanism underlying this phenomenon remains unclear. Both hormones can modulate the central somatostatinergic system that has an inhibitory effect on growth hormone (GH) expression, which plays an important ro...

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Bibliographic Details
Main Authors: Vicente Barrios, Elena López-Villar, Laura M. Frago, Sandra Canelles, Francisca Díaz-González, Emma Burgos-Ramos, Gema Frühbeck, Julie A. Chowen, Jesús Argente
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Cells
Subjects:
growth hormone axis
insulin signaling
leptin
lipid metabolism
liver
Online Access:https://www.mdpi.com/2073-4409/10/3/581

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