Altered lateral geniculate nucleus functional connectivity in migraine without aura: a resting-state functional MRI study
Abstract Objectives To investigate the structural and functional connectivity changes of lateral geniculate nucleus (LGN) and their relationships with clinical characteristics in patients without aura. Methods Conventional MRI, 3D structure images and resting state functional MRI were performed in 3...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2020-02-01
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| Series: | The Journal of Headache and Pain |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s10194-020-01086-6 |
| _version_ | 1818033022887264256 |
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| author | Di Zhang Xiaobin Huang Wen Su Yuchen Chen Peng Wang Cunnan Mao Zhengfei Miao Chunmei Liu Chenjie Xu Xindao Yin Xinying Wu |
| author_facet | Di Zhang Xiaobin Huang Wen Su Yuchen Chen Peng Wang Cunnan Mao Zhengfei Miao Chunmei Liu Chenjie Xu Xindao Yin Xinying Wu |
| author_sort | Di Zhang |
| collection | DOAJ |
| description | Abstract Objectives To investigate the structural and functional connectivity changes of lateral geniculate nucleus (LGN) and their relationships with clinical characteristics in patients without aura. Methods Conventional MRI, 3D structure images and resting state functional MRI were performed in 30 migraine patients without aura (MwoA) and 22 healthy controls (HC). The lateral geniculate nucleus volumes and the functional connectivity (FC) of bilateral lateral geniculate nucleus were computed and compared between groups. Results The lateral geniculate nucleus volumes in patient groups did not differ from the controls. The brain regions with increased FC of the left LGN mainly located in the left cerebellum and right lingual gyrus in MwoA compared with HC. The increased FC of right LGN located in left inferior frontal gyrus in MwoA compared with HC. The correlation analysis showed a positive correlation between VLSQ-8 score and the increased FC of left cerebellum and right lingual gyrus. Conclusions Photophobia in MwoA could be mediated by abnormal resting state functional connectivity in visual processing regions, the pain perception regulatory network and emotion regulation network. This result is valuable to further understanding about the clinical manifestation and pathogenesis of migraine. |
| first_indexed | 2024-12-10T06:16:40Z |
| format | Article |
| id | doaj.art-f2574a1d2ce3470593157546f8113072 |
| institution | Directory Open Access Journal |
| issn | 1129-2369 1129-2377 |
| language | English |
| last_indexed | 2024-12-10T06:16:40Z |
| publishDate | 2020-02-01 |
| publisher | BMC |
| record_format | Article |
| series | The Journal of Headache and Pain |
| spelling | doaj.art-f2574a1d2ce3470593157546f81130722022-12-22T01:59:26ZengBMCThe Journal of Headache and Pain1129-23691129-23772020-02-012111910.1186/s10194-020-01086-6Altered lateral geniculate nucleus functional connectivity in migraine without aura: a resting-state functional MRI studyDi Zhang0Xiaobin Huang1Wen Su2Yuchen Chen3Peng Wang4Cunnan Mao5Zhengfei Miao6Chunmei Liu7Chenjie Xu8Xindao Yin9Xinying Wu10Department of Radiology, Nanjing First Hospital, Nanjing Medical UniversityDepartment of Radiology, Nanjing First Hospital, Nanjing Medical UniversityDepartment of Radiology, Nanjing First Hospital, Nanjing Medical UniversityDepartment of Radiology, Nanjing First Hospital, Nanjing Medical UniversityDepartment of Radiology, Nanjing First Hospital, Nanjing Medical UniversityDepartment of Radiology, Nanjing First Hospital, Nanjing Medical UniversityDepartment of Radiology, Nanjing First Hospital, Nanjing Medical UniversityDepartment of Neurology, Nanjing First Hospital, Nanjing Medical UniversityDepartment of Pain Treatment, Nanjing First Hospital, Nanjing Medical UniversityDepartment of Radiology, Nanjing First Hospital, Nanjing Medical UniversityDepartment of Radiology, Nanjing First Hospital, Nanjing Medical UniversityAbstract Objectives To investigate the structural and functional connectivity changes of lateral geniculate nucleus (LGN) and their relationships with clinical characteristics in patients without aura. Methods Conventional MRI, 3D structure images and resting state functional MRI were performed in 30 migraine patients without aura (MwoA) and 22 healthy controls (HC). The lateral geniculate nucleus volumes and the functional connectivity (FC) of bilateral lateral geniculate nucleus were computed and compared between groups. Results The lateral geniculate nucleus volumes in patient groups did not differ from the controls. The brain regions with increased FC of the left LGN mainly located in the left cerebellum and right lingual gyrus in MwoA compared with HC. The increased FC of right LGN located in left inferior frontal gyrus in MwoA compared with HC. The correlation analysis showed a positive correlation between VLSQ-8 score and the increased FC of left cerebellum and right lingual gyrus. Conclusions Photophobia in MwoA could be mediated by abnormal resting state functional connectivity in visual processing regions, the pain perception regulatory network and emotion regulation network. This result is valuable to further understanding about the clinical manifestation and pathogenesis of migraine.http://link.springer.com/article/10.1186/s10194-020-01086-6MigraineLateral geniculate nucleusPhotophobiaFunctional connectivityfMRI |
| spellingShingle | Di Zhang Xiaobin Huang Wen Su Yuchen Chen Peng Wang Cunnan Mao Zhengfei Miao Chunmei Liu Chenjie Xu Xindao Yin Xinying Wu Altered lateral geniculate nucleus functional connectivity in migraine without aura: a resting-state functional MRI study The Journal of Headache and Pain Migraine Lateral geniculate nucleus Photophobia Functional connectivity fMRI |
| title | Altered lateral geniculate nucleus functional connectivity in migraine without aura: a resting-state functional MRI study |
| title_full | Altered lateral geniculate nucleus functional connectivity in migraine without aura: a resting-state functional MRI study |
| title_fullStr | Altered lateral geniculate nucleus functional connectivity in migraine without aura: a resting-state functional MRI study |
| title_full_unstemmed | Altered lateral geniculate nucleus functional connectivity in migraine without aura: a resting-state functional MRI study |
| title_short | Altered lateral geniculate nucleus functional connectivity in migraine without aura: a resting-state functional MRI study |
| title_sort | altered lateral geniculate nucleus functional connectivity in migraine without aura a resting state functional mri study |
| topic | Migraine Lateral geniculate nucleus Photophobia Functional connectivity fMRI |
| url | http://link.springer.com/article/10.1186/s10194-020-01086-6 |
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