3D Bioprinting for Next-Generation Personalized Medicine
In the past decade, immense progress has been made in advancing personalized medicine to effectively address patient-specific disease complexities in order to develop individualized treatment strategies. In particular, the emergence of 3D bioprinting for in vitro models of tissue and organ engineeri...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/24/7/6357 |
| _version_ | 1797607848156332032 |
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| author | Ethan Hau Yin Lam Fengqing Yu Sabrina Zhu Zongjie Wang |
| author_facet | Ethan Hau Yin Lam Fengqing Yu Sabrina Zhu Zongjie Wang |
| author_sort | Ethan Hau Yin Lam |
| collection | DOAJ |
| description | In the past decade, immense progress has been made in advancing personalized medicine to effectively address patient-specific disease complexities in order to develop individualized treatment strategies. In particular, the emergence of 3D bioprinting for in vitro models of tissue and organ engineering presents novel opportunities to improve personalized medicine. However, the existing bioprinted constructs are not yet able to fulfill the ultimate goal: an anatomically realistic organ with mature biological functions. Current bioprinting approaches have technical challenges in terms of precise cell deposition, effective differentiation, proper vascularization, and innervation. This review introduces the principles and realizations of bioprinting with a strong focus on the predominant techniques, including extrusion printing and digital light processing (DLP). We further discussed the applications of bioprinted constructs, including the engraftment of stem cells as personalized implants for regenerative medicine and in vitro high-throughput drug development models for drug discovery. While no one-size-fits-all approach to bioprinting has emerged, the rapid progress and promising results of preliminary studies have demonstrated that bioprinting could serve as an empowering technology to resolve critical challenges in personalized medicine. |
| first_indexed | 2024-03-11T05:36:22Z |
| format | Article |
| id | doaj.art-f258579641024c41a9fa52e30c176d18 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T05:36:22Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-f258579641024c41a9fa52e30c176d182023-11-17T16:49:56ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-03-01247635710.3390/ijms240763573D Bioprinting for Next-Generation Personalized MedicineEthan Hau Yin Lam0Fengqing Yu1Sabrina Zhu2Zongjie Wang3Faculty of Arts and Science, University of Toronto, Toronto, ON M5S 3G3, CanadaFaculty of Arts and Science, University of Toronto, Toronto, ON M5S 3G3, CanadaFaculty of Arts and Science, University of Toronto, Toronto, ON M5S 3G3, CanadaLeslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON M5S 3M2, CanadaIn the past decade, immense progress has been made in advancing personalized medicine to effectively address patient-specific disease complexities in order to develop individualized treatment strategies. In particular, the emergence of 3D bioprinting for in vitro models of tissue and organ engineering presents novel opportunities to improve personalized medicine. However, the existing bioprinted constructs are not yet able to fulfill the ultimate goal: an anatomically realistic organ with mature biological functions. Current bioprinting approaches have technical challenges in terms of precise cell deposition, effective differentiation, proper vascularization, and innervation. This review introduces the principles and realizations of bioprinting with a strong focus on the predominant techniques, including extrusion printing and digital light processing (DLP). We further discussed the applications of bioprinted constructs, including the engraftment of stem cells as personalized implants for regenerative medicine and in vitro high-throughput drug development models for drug discovery. While no one-size-fits-all approach to bioprinting has emerged, the rapid progress and promising results of preliminary studies have demonstrated that bioprinting could serve as an empowering technology to resolve critical challenges in personalized medicine.https://www.mdpi.com/1422-0067/24/7/6357bioprintingbiomaterialdrug discoverypersonalized medicineprecision medicineregenerative medicine |
| spellingShingle | Ethan Hau Yin Lam Fengqing Yu Sabrina Zhu Zongjie Wang 3D Bioprinting for Next-Generation Personalized Medicine International Journal of Molecular Sciences bioprinting biomaterial drug discovery personalized medicine precision medicine regenerative medicine |
| title | 3D Bioprinting for Next-Generation Personalized Medicine |
| title_full | 3D Bioprinting for Next-Generation Personalized Medicine |
| title_fullStr | 3D Bioprinting for Next-Generation Personalized Medicine |
| title_full_unstemmed | 3D Bioprinting for Next-Generation Personalized Medicine |
| title_short | 3D Bioprinting for Next-Generation Personalized Medicine |
| title_sort | 3d bioprinting for next generation personalized medicine |
| topic | bioprinting biomaterial drug discovery personalized medicine precision medicine regenerative medicine |
| url | https://www.mdpi.com/1422-0067/24/7/6357 |
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