Sickle cell trait in São Tomé e Príncipe: a population-based prevalence study in women of reproductive age
Abstract Background Sickle Cell Disorder is Africa’s most prevalent genetic disease. Yet, it remains a neglected condition, with high mortality under-five, and a lack of population-based studies in the region. This is the first of its kind in São Tomé e Príncipe, aiming to estimate the prevalence of...
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| Format: | Article |
| Language: | English |
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BMC
2024-03-01
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| Series: | BMC Public Health |
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| Online Access: | https://doi.org/10.1186/s12889-024-17761-1 |
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| author | Guilherme Queiroz Celdidy Monteiro Licínio Manco Luís Relvas Maria de Jesus Trovoada Andreia Leite Celeste Bento |
| author_facet | Guilherme Queiroz Celdidy Monteiro Licínio Manco Luís Relvas Maria de Jesus Trovoada Andreia Leite Celeste Bento |
| author_sort | Guilherme Queiroz |
| collection | DOAJ |
| description | Abstract Background Sickle Cell Disorder is Africa’s most prevalent genetic disease. Yet, it remains a neglected condition, with high mortality under-five, and a lack of population-based studies in the region. This is the first of its kind in São Tomé e Príncipe, aiming to estimate the prevalence of sickle cell trait and other haemoglobin variants in women of reproductive age and its associated factors. Methods We conducted a cluster survey in 35 neighbourhoods. Haemoglobin was assessed through point-of-care capillary electrophoresis or high-performance liquid chromatography, and sociodemographic data through questionnaires. The weighted prevalence of sickle cell trait (HbAS) and HbC carriers was estimated with a 95% confidence interval (95% CI). We calculated weighted prevalence ratios (95% CI) through robust Poisson regression for its association with age and individual and collective genetic heritage. Findings The prevalence of sickle cell trait in women of reproductive age in São Tomé e Príncipe (n = 376) was 13.45% (95% CI: 9.05-19.00). The prevalence of HbC carriers was 8.00% (95% CI: 4.71-12.00). Older age and speaking Forro or Angolar were positively associated with having sickle cell trait. Interpretation The prevalence of sickle cell trait in São Tomé e Príncipe ranks high in the West African region. The country should follow international guidelines, implementing newborn screening and comprehensive healthcare management. |
| first_indexed | 2024-04-24T19:51:12Z |
| format | Article |
| id | doaj.art-f2585f043e604a3a9ce56395342aac1e |
| institution | Directory Open Access Journal |
| issn | 1471-2458 |
| language | English |
| last_indexed | 2024-04-24T19:51:12Z |
| publishDate | 2024-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Public Health |
| spelling | doaj.art-f2585f043e604a3a9ce56395342aac1e2024-03-24T12:36:36ZengBMCBMC Public Health1471-24582024-03-012411810.1186/s12889-024-17761-1Sickle cell trait in São Tomé e Príncipe: a population-based prevalence study in women of reproductive ageGuilherme Queiroz0Celdidy Monteiro1Licínio Manco2Luís Relvas3Maria de Jesus Trovoada4Andreia Leite5Celeste Bento6Centro de Investigação em Antropologia e Saúde (CIAS), Universidade de CoimbraHospital Dr. Ayres de MenezesCentro de Investigação em Antropologia e Saúde (CIAS), Universidade de CoimbraUnidade Funcional Hematologia Molecular, Unidade Local de Saúde de CoimbraCentro Nacional de EndemiasNOVA National School of Public Health, Public Health Research Centre, Comprehensive Health Research Center, CHRC, NOVA University LisbonCentro de Investigação em Antropologia e Saúde (CIAS), Universidade de CoimbraAbstract Background Sickle Cell Disorder is Africa’s most prevalent genetic disease. Yet, it remains a neglected condition, with high mortality under-five, and a lack of population-based studies in the region. This is the first of its kind in São Tomé e Príncipe, aiming to estimate the prevalence of sickle cell trait and other haemoglobin variants in women of reproductive age and its associated factors. Methods We conducted a cluster survey in 35 neighbourhoods. Haemoglobin was assessed through point-of-care capillary electrophoresis or high-performance liquid chromatography, and sociodemographic data through questionnaires. The weighted prevalence of sickle cell trait (HbAS) and HbC carriers was estimated with a 95% confidence interval (95% CI). We calculated weighted prevalence ratios (95% CI) through robust Poisson regression for its association with age and individual and collective genetic heritage. Findings The prevalence of sickle cell trait in women of reproductive age in São Tomé e Príncipe (n = 376) was 13.45% (95% CI: 9.05-19.00). The prevalence of HbC carriers was 8.00% (95% CI: 4.71-12.00). Older age and speaking Forro or Angolar were positively associated with having sickle cell trait. Interpretation The prevalence of sickle cell trait in São Tomé e Príncipe ranks high in the West African region. The country should follow international guidelines, implementing newborn screening and comprehensive healthcare management.https://doi.org/10.1186/s12889-024-17761-1Sickle cell diseaseHaemoglobinopathiesGeneticsCluster samplingSub-saharian Africa |
| spellingShingle | Guilherme Queiroz Celdidy Monteiro Licínio Manco Luís Relvas Maria de Jesus Trovoada Andreia Leite Celeste Bento Sickle cell trait in São Tomé e Príncipe: a population-based prevalence study in women of reproductive age BMC Public Health Sickle cell disease Haemoglobinopathies Genetics Cluster sampling Sub-saharian Africa |
| title | Sickle cell trait in São Tomé e Príncipe: a population-based prevalence study in women of reproductive age |
| title_full | Sickle cell trait in São Tomé e Príncipe: a population-based prevalence study in women of reproductive age |
| title_fullStr | Sickle cell trait in São Tomé e Príncipe: a population-based prevalence study in women of reproductive age |
| title_full_unstemmed | Sickle cell trait in São Tomé e Príncipe: a population-based prevalence study in women of reproductive age |
| title_short | Sickle cell trait in São Tomé e Príncipe: a population-based prevalence study in women of reproductive age |
| title_sort | sickle cell trait in sao tome e principe a population based prevalence study in women of reproductive age |
| topic | Sickle cell disease Haemoglobinopathies Genetics Cluster sampling Sub-saharian Africa |
| url | https://doi.org/10.1186/s12889-024-17761-1 |
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