Molecular Aberrations Stratify Grade 2 Astrocytomas Into Several Rare Entities: Prognostic and Therapeutic Implications
The identification of specific molecular aberrations guides the prognostic stratification and management of grade 2 astrocytomas. Mutations in isocitrate dehydrogenase (IDH) 1 and 2, found in the majority of adult diffuse low-grade glioma (DLGG), seem to relate to a favorable prognosis compared to I...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.866623/full |
| _version_ | 1818230190662221824 |
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| author | Valeria Internò Valeria Internò Giacomo Triggiano Pierluigi De Santis Luigia Stefania Stucci Marco Tucci Marco Tucci Camillo Porta Camillo Porta |
| author_facet | Valeria Internò Valeria Internò Giacomo Triggiano Pierluigi De Santis Luigia Stefania Stucci Marco Tucci Marco Tucci Camillo Porta Camillo Porta |
| author_sort | Valeria Internò |
| collection | DOAJ |
| description | The identification of specific molecular aberrations guides the prognostic stratification and management of grade 2 astrocytomas. Mutations in isocitrate dehydrogenase (IDH) 1 and 2, found in the majority of adult diffuse low-grade glioma (DLGG), seem to relate to a favorable prognosis compared to IDH wild-type (IDH-wt) counterparts. Moreover, the IDH-wt group can develop additional molecular alterations worsening the prognosis, such as epidermal growth factor receptor amplification (EGFR-amp) and mutation of the promoter of telomerase reverse transcriptase (pTERT-mut). This review analyzes the prognostic impact and therapeutic implications of genetic alterations in adult LGG. |
| first_indexed | 2024-12-12T10:30:34Z |
| format | Article |
| id | doaj.art-f25a001b23594a86b5e680c666d460b4 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-12T10:30:34Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-f25a001b23594a86b5e680c666d460b42022-12-22T00:27:23ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-06-011210.3389/fonc.2022.866623866623Molecular Aberrations Stratify Grade 2 Astrocytomas Into Several Rare Entities: Prognostic and Therapeutic ImplicationsValeria Internò0Valeria Internò1Giacomo Triggiano2Pierluigi De Santis3Luigia Stefania Stucci4Marco Tucci5Marco Tucci6Camillo Porta7Camillo Porta8Department of Interdisciplinary Medicine, University of Bari ‘Aldo Moro’, Bari, ItalyDivision of Medical Oncology, Policlinico Hospital of Bari, Bari, ItalyDivision of Medical Oncology, Policlinico Hospital of Bari, Bari, ItalyDivision of Medical Oncology, Policlinico Hospital of Bari, Bari, ItalyDivision of Medical Oncology, Policlinico Hospital of Bari, Bari, ItalyDepartment of Interdisciplinary Medicine, University of Bari ‘Aldo Moro’, Bari, ItalyDivision of Medical Oncology, Policlinico Hospital of Bari, Bari, ItalyDepartment of Interdisciplinary Medicine, University of Bari ‘Aldo Moro’, Bari, ItalyDivision of Medical Oncology, Policlinico Hospital of Bari, Bari, ItalyThe identification of specific molecular aberrations guides the prognostic stratification and management of grade 2 astrocytomas. Mutations in isocitrate dehydrogenase (IDH) 1 and 2, found in the majority of adult diffuse low-grade glioma (DLGG), seem to relate to a favorable prognosis compared to IDH wild-type (IDH-wt) counterparts. Moreover, the IDH-wt group can develop additional molecular alterations worsening the prognosis, such as epidermal growth factor receptor amplification (EGFR-amp) and mutation of the promoter of telomerase reverse transcriptase (pTERT-mut). This review analyzes the prognostic impact and therapeutic implications of genetic alterations in adult LGG.https://www.frontiersin.org/articles/10.3389/fonc.2022.866623/fulldiffuse low-grade gliomasprognostic molecular stratificationIDH-wt grade 2 astrocytomapTERT mutationEGFR amplification |
| spellingShingle | Valeria Internò Valeria Internò Giacomo Triggiano Pierluigi De Santis Luigia Stefania Stucci Marco Tucci Marco Tucci Camillo Porta Camillo Porta Molecular Aberrations Stratify Grade 2 Astrocytomas Into Several Rare Entities: Prognostic and Therapeutic Implications Frontiers in Oncology diffuse low-grade gliomas prognostic molecular stratification IDH-wt grade 2 astrocytoma pTERT mutation EGFR amplification |
| title | Molecular Aberrations Stratify Grade 2 Astrocytomas Into Several Rare Entities: Prognostic and Therapeutic Implications |
| title_full | Molecular Aberrations Stratify Grade 2 Astrocytomas Into Several Rare Entities: Prognostic and Therapeutic Implications |
| title_fullStr | Molecular Aberrations Stratify Grade 2 Astrocytomas Into Several Rare Entities: Prognostic and Therapeutic Implications |
| title_full_unstemmed | Molecular Aberrations Stratify Grade 2 Astrocytomas Into Several Rare Entities: Prognostic and Therapeutic Implications |
| title_short | Molecular Aberrations Stratify Grade 2 Astrocytomas Into Several Rare Entities: Prognostic and Therapeutic Implications |
| title_sort | molecular aberrations stratify grade 2 astrocytomas into several rare entities prognostic and therapeutic implications |
| topic | diffuse low-grade gliomas prognostic molecular stratification IDH-wt grade 2 astrocytoma pTERT mutation EGFR amplification |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.866623/full |
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