Molecular Aberrations Stratify Grade 2 Astrocytomas Into Several Rare Entities: Prognostic and Therapeutic Implications

Molecular Aberrations Stratify Grade 2 Astrocytomas Into Several Rare Entities: Prognostic and Therapeutic Implications

The identification of specific molecular aberrations guides the prognostic stratification and management of grade 2 astrocytomas. Mutations in isocitrate dehydrogenase (IDH) 1 and 2, found in the majority of adult diffuse low-grade glioma (DLGG), seem to relate to a favorable prognosis compared to I...

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Bibliographic Details
Main Authors: Valeria Internò, Giacomo Triggiano, Pierluigi De Santis, Luigia Stefania Stucci, Marco Tucci, Camillo Porta
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Oncology
Subjects:
diffuse low-grade gliomas
prognostic molecular stratification
IDH-wt grade 2 astrocytoma
pTERT mutation
EGFR amplification
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.866623/full

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