Clinical features of patients with type 2 diabetes mellitus and hepatitis C infection
The objective of the present cross-sectional study was to assess the prevalence and the clinical and laboratory features of hepatitis C virus (HCV)-positive patients with type 2 diabetes mellitus (DM) attending either an outpatient clinic or hemodialysis units. Serologic-HCV testing was performed in...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Associação Brasileira de Divulgação Científica
2012-03-01
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| Series: | Brazilian Journal of Medical and Biological Research |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012000300015 |
| _version_ | 1818029448068333568 |
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| author | L.F. Greca L.C. Pinto D.R. Rados L.H. Canani J.L. Gross |
| author_facet | L.F. Greca L.C. Pinto D.R. Rados L.H. Canani J.L. Gross |
| author_sort | L.F. Greca |
| collection | DOAJ |
| description | The objective of the present cross-sectional study was to assess the prevalence and the clinical and laboratory features of hepatitis C virus (HCV)-positive patients with type 2 diabetes mellitus (DM) attending either an outpatient clinic or hemodialysis units. Serologic-HCV testing was performed in 489 type 2 DM patients (303 outpatients and 186 on dialysis). A structured assessment of clinical, laboratory and DM-related complications was performed and the patients were then compared according to HCV infection status. Mean patient age was 60 years; HCV positivity (HCV+) was observed in 39 of 303 (12.9%) outpatients and in 34 of 186 (18.7%) dialysis patients. Among HCV+ patients, 32 were men (43.8%). HCV+ patients had higher serum levels of aspartate aminotransferase (0.90 ± 0.83 vs 0.35 ± 0.13 µKat/L), alanine aminotransferase (0.88 ± 0.93 vs 0.38 ± 0.19 µKat/L), gamma-glutamyl transferase (1.57 ± 2.52 vs 0.62 ± 0.87 µKat/L; P < 0.001), and serum iron (17.65 ± 6.68 vs 14.96 ± 4.72 µM; P = 0.011), and lower leukocyte and platelet counts (P = 0.010 and P < 0.001, respectively) than HCV-negative (HCV-) patients. HCV+ dialysis patients had higher diastolic blood pressure than HCV- patients (87.5 ± 6.7 vs 81.5 ± 6.0 mmHg; P = 0.005) and a lower prevalence of diabetic retinopathy (75 vs 92.7%; P = 0.007). In conclusion, our study showed that HCV is common among subjects with type 2 DM but is not associated with a higher prevalence of chronic diabetic complications. |
| first_indexed | 2024-12-10T05:19:51Z |
| format | Article |
| id | doaj.art-f25b31b5ed52486a9cf150ce97fa4499 |
| institution | Directory Open Access Journal |
| issn | 0100-879X 1414-431X |
| language | English |
| last_indexed | 2024-12-10T05:19:51Z |
| publishDate | 2012-03-01 |
| publisher | Associação Brasileira de Divulgação Científica |
| record_format | Article |
| series | Brazilian Journal of Medical and Biological Research |
| spelling | doaj.art-f25b31b5ed52486a9cf150ce97fa44992022-12-22T02:00:51ZengAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological Research0100-879X1414-431X2012-03-01453284290Clinical features of patients with type 2 diabetes mellitus and hepatitis C infectionL.F. GrecaL.C. PintoD.R. RadosL.H. CananiJ.L. GrossThe objective of the present cross-sectional study was to assess the prevalence and the clinical and laboratory features of hepatitis C virus (HCV)-positive patients with type 2 diabetes mellitus (DM) attending either an outpatient clinic or hemodialysis units. Serologic-HCV testing was performed in 489 type 2 DM patients (303 outpatients and 186 on dialysis). A structured assessment of clinical, laboratory and DM-related complications was performed and the patients were then compared according to HCV infection status. Mean patient age was 60 years; HCV positivity (HCV+) was observed in 39 of 303 (12.9%) outpatients and in 34 of 186 (18.7%) dialysis patients. Among HCV+ patients, 32 were men (43.8%). HCV+ patients had higher serum levels of aspartate aminotransferase (0.90 ± 0.83 vs 0.35 ± 0.13 µKat/L), alanine aminotransferase (0.88 ± 0.93 vs 0.38 ± 0.19 µKat/L), gamma-glutamyl transferase (1.57 ± 2.52 vs 0.62 ± 0.87 µKat/L; P < 0.001), and serum iron (17.65 ± 6.68 vs 14.96 ± 4.72 µM; P = 0.011), and lower leukocyte and platelet counts (P = 0.010 and P < 0.001, respectively) than HCV-negative (HCV-) patients. HCV+ dialysis patients had higher diastolic blood pressure than HCV- patients (87.5 ± 6.7 vs 81.5 ± 6.0 mmHg; P = 0.005) and a lower prevalence of diabetic retinopathy (75 vs 92.7%; P = 0.007). In conclusion, our study showed that HCV is common among subjects with type 2 DM but is not associated with a higher prevalence of chronic diabetic complications.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012000300015Type 2 diabetesHepatitis CDialysis |
| spellingShingle | L.F. Greca L.C. Pinto D.R. Rados L.H. Canani J.L. Gross Clinical features of patients with type 2 diabetes mellitus and hepatitis C infection Brazilian Journal of Medical and Biological Research Type 2 diabetes Hepatitis C Dialysis |
| title | Clinical features of patients with type 2 diabetes mellitus and hepatitis C infection |
| title_full | Clinical features of patients with type 2 diabetes mellitus and hepatitis C infection |
| title_fullStr | Clinical features of patients with type 2 diabetes mellitus and hepatitis C infection |
| title_full_unstemmed | Clinical features of patients with type 2 diabetes mellitus and hepatitis C infection |
| title_short | Clinical features of patients with type 2 diabetes mellitus and hepatitis C infection |
| title_sort | clinical features of patients with type 2 diabetes mellitus and hepatitis c infection |
| topic | Type 2 diabetes Hepatitis C Dialysis |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012000300015 |
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