Synergic versus Antagonist Effects of Rutin on Gallic Acid or Coumarin Incorporated into Chitosan Active Films: Impacts on Their Release Kinetics and Antioxidant Activity
This work deals with the study of the release and antioxidant activity kinetics of three natural antioxidants associated as binary mixture (coumarin, and/or gallic acid and rutin) from chitosan films. Antioxidants were incorporated into film alone or in binary mixture. The aim was to determine the i...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-10-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/12/11/1934 |
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| author | Elizabeth Jacobs Odile Chambin Frédéric Debeaufort Nasreddine Benbettaieb |
| author_facet | Elizabeth Jacobs Odile Chambin Frédéric Debeaufort Nasreddine Benbettaieb |
| author_sort | Elizabeth Jacobs |
| collection | DOAJ |
| description | This work deals with the study of the release and antioxidant activity kinetics of three natural antioxidants associated as binary mixture (coumarin, and/or gallic acid and rutin) from chitosan films. Antioxidants were incorporated into film alone or in binary mixture. The aim was to determine the influence of rutin on the phenolic acid and benzopyrone. The UV-visible light transmission spectra of the films were also investigated. Neat chitosan films and chitosan incorporated coumarin exhibited high transmittance in the UV-visible light range, while GA-added chitosan films showed excellent UV light barrier properties. The molecular interactions between chitosan network and antioxidants were confirmed by FTIR where spectra displayed a shift of the amide-III peak. Rutin has a complex structure that can undergo ionization. The chitosan network structure induced change was found to influence the release behavior. The film containing rutin showed the highest antioxidant activity (65.58 ± 0.26%), followed by gallic acid (44.82 ± 3.73%), while coumarin displayed the lowest activity (27.27 ± 4.04%). The kinetic rate against DPPH-free radical of rutin is three times higher than coumarin. The kinetic rates were influenced by the structure and interactions of the antioxidants with chitosan. Rutin exhibited a slow release due to its molecular interactions with chitosan, while coumarin and gallic acid showed faster release. The diffusion coefficient of coumarin is 900 times higher than that of rutin. The rutin presence significantly delayed the release of the gallic acid and coumarin, suggesting an antagonistic effect. However, their presence weakly affects the release behavior of rutin. |
| first_indexed | 2024-03-09T17:05:01Z |
| format | Article |
| id | doaj.art-f25c6d43fac44f159d991caba0d7e2a0 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-09T17:05:01Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-f25c6d43fac44f159d991caba0d7e2a02023-11-24T14:25:41ZengMDPI AGAntioxidants2076-39212023-10-011211193410.3390/antiox12111934Synergic versus Antagonist Effects of Rutin on Gallic Acid or Coumarin Incorporated into Chitosan Active Films: Impacts on Their Release Kinetics and Antioxidant ActivityElizabeth Jacobs0Odile Chambin1Frédéric Debeaufort2Nasreddine Benbettaieb3Bioscience Department, Munster Technological University-Cork Campus, T12 P928 Cork, IrelandFood and Wine Physico-Chemistry Unit, Institut Agro Dijon-Joint Unit Food Processing and Microbiology UMR PAM, Université de Bourgogne, 21000 Dijon, FranceFood and Wine Physico-Chemistry Unit, Institut Agro Dijon-Joint Unit Food Processing and Microbiology UMR PAM, Université de Bourgogne, 21000 Dijon, FranceFood and Wine Physico-Chemistry Unit, Institut Agro Dijon-Joint Unit Food Processing and Microbiology UMR PAM, Université de Bourgogne, 21000 Dijon, FranceThis work deals with the study of the release and antioxidant activity kinetics of three natural antioxidants associated as binary mixture (coumarin, and/or gallic acid and rutin) from chitosan films. Antioxidants were incorporated into film alone or in binary mixture. The aim was to determine the influence of rutin on the phenolic acid and benzopyrone. The UV-visible light transmission spectra of the films were also investigated. Neat chitosan films and chitosan incorporated coumarin exhibited high transmittance in the UV-visible light range, while GA-added chitosan films showed excellent UV light barrier properties. The molecular interactions between chitosan network and antioxidants were confirmed by FTIR where spectra displayed a shift of the amide-III peak. Rutin has a complex structure that can undergo ionization. The chitosan network structure induced change was found to influence the release behavior. The film containing rutin showed the highest antioxidant activity (65.58 ± 0.26%), followed by gallic acid (44.82 ± 3.73%), while coumarin displayed the lowest activity (27.27 ± 4.04%). The kinetic rate against DPPH-free radical of rutin is three times higher than coumarin. The kinetic rates were influenced by the structure and interactions of the antioxidants with chitosan. Rutin exhibited a slow release due to its molecular interactions with chitosan, while coumarin and gallic acid showed faster release. The diffusion coefficient of coumarin is 900 times higher than that of rutin. The rutin presence significantly delayed the release of the gallic acid and coumarin, suggesting an antagonistic effect. However, their presence weakly affects the release behavior of rutin.https://www.mdpi.com/2076-3921/12/11/1934combined antioxidant effectstructure-reaction relationdiffusivityDDPHrelease |
| spellingShingle | Elizabeth Jacobs Odile Chambin Frédéric Debeaufort Nasreddine Benbettaieb Synergic versus Antagonist Effects of Rutin on Gallic Acid or Coumarin Incorporated into Chitosan Active Films: Impacts on Their Release Kinetics and Antioxidant Activity Antioxidants combined antioxidant effect structure-reaction relation diffusivity DDPH release |
| title | Synergic versus Antagonist Effects of Rutin on Gallic Acid or Coumarin Incorporated into Chitosan Active Films: Impacts on Their Release Kinetics and Antioxidant Activity |
| title_full | Synergic versus Antagonist Effects of Rutin on Gallic Acid or Coumarin Incorporated into Chitosan Active Films: Impacts on Their Release Kinetics and Antioxidant Activity |
| title_fullStr | Synergic versus Antagonist Effects of Rutin on Gallic Acid or Coumarin Incorporated into Chitosan Active Films: Impacts on Their Release Kinetics and Antioxidant Activity |
| title_full_unstemmed | Synergic versus Antagonist Effects of Rutin on Gallic Acid or Coumarin Incorporated into Chitosan Active Films: Impacts on Their Release Kinetics and Antioxidant Activity |
| title_short | Synergic versus Antagonist Effects of Rutin on Gallic Acid or Coumarin Incorporated into Chitosan Active Films: Impacts on Their Release Kinetics and Antioxidant Activity |
| title_sort | synergic versus antagonist effects of rutin on gallic acid or coumarin incorporated into chitosan active films impacts on their release kinetics and antioxidant activity |
| topic | combined antioxidant effect structure-reaction relation diffusivity DDPH release |
| url | https://www.mdpi.com/2076-3921/12/11/1934 |
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