The role for ketogenic diets in epilepsy and status epilepticus in adults
Ketogenic diet (KD) therapies are high fat, low carbohydrate diets designed to mimic a fasting state. Although studies demonstrate KD’s success in reducing seizures stretching back nearly a century, the last 25 years have seen a resurgence in diet therapy for the management of drug-resistant epileps...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2017-01-01
|
| Series: | Clinical Neurophysiology Practice |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2467981X1730015X |
| _version_ | 1818509102501855232 |
|---|---|
| author | Tanya J. Williams Mackenzie C. Cervenka |
| author_facet | Tanya J. Williams Mackenzie C. Cervenka |
| author_sort | Tanya J. Williams |
| collection | DOAJ |
| description | Ketogenic diet (KD) therapies are high fat, low carbohydrate diets designed to mimic a fasting state. Although studies demonstrate KD’s success in reducing seizures stretching back nearly a century, the last 25 years have seen a resurgence in diet therapy for the management of drug-resistant epilepsy in children as well as adults. With ≥50% seizure reduction efficacy rates in adults of 22–55% for the classic KD and 12–67% for the modified Atkins diet, diet therapy may be in many instances comparable to a trial of an additional anti-epileptic medication and potentially with fewer side effects and other health benefits. Moreover, ketogenic diets offer promising new adjunctive strategies for the treatment of acute status epilepticus in the intensive care setting. Here, we review the efficacy and utility of ketogenic diets for the management of chronic epilepsy and refractory status epilepticus in adults and offer practical guidelines for diet implementation and maintenance. Keywords: Ketogenic diet, Modified Atkins diet, Epilepsy, Drug-resistant epilepsy, Refractory status epilepticus |
| first_indexed | 2024-12-10T22:40:53Z |
| format | Article |
| id | doaj.art-f25c9b1963d948b7850e6ef2123aa982 |
| institution | Directory Open Access Journal |
| issn | 2467-981X |
| language | English |
| last_indexed | 2024-12-10T22:40:53Z |
| publishDate | 2017-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Clinical Neurophysiology Practice |
| spelling | doaj.art-f25c9b1963d948b7850e6ef2123aa9822022-12-22T01:30:43ZengElsevierClinical Neurophysiology Practice2467-981X2017-01-012154160The role for ketogenic diets in epilepsy and status epilepticus in adultsTanya J. Williams0Mackenzie C. Cervenka1Department of Neurology, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Meyer 2-147, Baltimore, MD, USACorresponding author at: Department of Neurology, Johns Hopkins Hospital, 600 North Wolfe Street, Meyer 2-147, Baltimore, MD 21287, USA.; Department of Neurology, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Meyer 2-147, Baltimore, MD, USAKetogenic diet (KD) therapies are high fat, low carbohydrate diets designed to mimic a fasting state. Although studies demonstrate KD’s success in reducing seizures stretching back nearly a century, the last 25 years have seen a resurgence in diet therapy for the management of drug-resistant epilepsy in children as well as adults. With ≥50% seizure reduction efficacy rates in adults of 22–55% for the classic KD and 12–67% for the modified Atkins diet, diet therapy may be in many instances comparable to a trial of an additional anti-epileptic medication and potentially with fewer side effects and other health benefits. Moreover, ketogenic diets offer promising new adjunctive strategies for the treatment of acute status epilepticus in the intensive care setting. Here, we review the efficacy and utility of ketogenic diets for the management of chronic epilepsy and refractory status epilepticus in adults and offer practical guidelines for diet implementation and maintenance. Keywords: Ketogenic diet, Modified Atkins diet, Epilepsy, Drug-resistant epilepsy, Refractory status epilepticushttp://www.sciencedirect.com/science/article/pii/S2467981X1730015X |
| spellingShingle | Tanya J. Williams Mackenzie C. Cervenka The role for ketogenic diets in epilepsy and status epilepticus in adults Clinical Neurophysiology Practice |
| title | The role for ketogenic diets in epilepsy and status epilepticus in adults |
| title_full | The role for ketogenic diets in epilepsy and status epilepticus in adults |
| title_fullStr | The role for ketogenic diets in epilepsy and status epilepticus in adults |
| title_full_unstemmed | The role for ketogenic diets in epilepsy and status epilepticus in adults |
| title_short | The role for ketogenic diets in epilepsy and status epilepticus in adults |
| title_sort | role for ketogenic diets in epilepsy and status epilepticus in adults |
| url | http://www.sciencedirect.com/science/article/pii/S2467981X1730015X |
| work_keys_str_mv | AT tanyajwilliams theroleforketogenicdietsinepilepsyandstatusepilepticusinadults AT mackenzieccervenka theroleforketogenicdietsinepilepsyandstatusepilepticusinadults AT tanyajwilliams roleforketogenicdietsinepilepsyandstatusepilepticusinadults AT mackenzieccervenka roleforketogenicdietsinepilepsyandstatusepilepticusinadults |