In vivo characterization of the activities of novel cyclodipeptide oxidases: new tools for increasing chemical diversity of bioproduced 2,5-diketopiperazines in Escherichia coli

In vivo characterization of the activities of novel cyclodipeptide oxidases: new tools for increasing chemical diversity of bioproduced 2,5-diketopiperazines in Escherichia coli

Abstract Background Cyclodipeptide oxidases (CDOs) are enzymes involved in the biosynthesis of 2,5-diketopiperazines, a class of naturally occurring compounds with a large range of pharmaceutical activities. CDOs belong to cyclodipeptide synthase (CDPS)-dependent pathways, in which they play an earl...

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Bibliografiska uppgifter
Huvudupphovsmän: Fabien Le Chevalier, Isabelle Correia, Lucrèce Matheron, Morgan Babin, Mireille Moutiez, Nicolas Canu, Muriel Gondry, Olivier Lequin, Pascal Belin
Materialtyp: Artikel
Språk:English
Publicerad: BMC 2020-09-01
Serie:Microbial Cell Factories
Ämnen:
Synthetic biology
Combinatorial biosynthesis
Natural products
2,5-diketopiperazine
Cyclodipeptide synthase
Cyclodipeptide oxidase
Länkar:http://link.springer.com/article/10.1186/s12934-020-01432-y

Internet

http://link.springer.com/article/10.1186/s12934-020-01432-y

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