Infective endocarditis with Osler’s nodule in a patient with Osler’s disease: a case report and review of the literature
Abstract Background Hereditary hemorrhagic telangiectasia, also known as Osler–Weber–Rendu disease, induces arteriovenous malformations in visceral organs. Arteriovenous malformations increase the risk of severe infections and are a common complication associated with hemorrhagic telangiectasia. How...
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| Format: | Article |
| Language: | English |
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BMC
2022-05-01
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| Series: | Journal of Medical Case Reports |
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| Online Access: | https://doi.org/10.1186/s13256-022-03427-2 |
| _version_ | 1818213717391704064 |
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| author | Genki Naruse Takatomo Watanabe Hiroyuki Okura |
| author_facet | Genki Naruse Takatomo Watanabe Hiroyuki Okura |
| author_sort | Genki Naruse |
| collection | DOAJ |
| description | Abstract Background Hereditary hemorrhagic telangiectasia, also known as Osler–Weber–Rendu disease, induces arteriovenous malformations in visceral organs. Arteriovenous malformations increase the risk of severe infections and are a common complication associated with hemorrhagic telangiectasia. However, cases of endocarditis associated with hemorrhagic telangiectasia are rarely reported. Although hemorrhagic telangiectasia causes erythematous macules on the extremities, these macules are usually painless. We encountered a rare case of infective endocarditis in a patient with Osler–Weber–Rendu disease. Case presentation A 52-year-old Japanese woman who was diagnosed with hemorrhagic telangiectasia 5 years prior presented to our hospital with fever and muscular pain. She had erythematous nodules and tenderness on the finger, heel, and toe, suggestive of Osler’s nodes. A physical examination revealed tachycardia with a 3/6 pansystolic murmur. A transesophageal echocardiogram showed vegetations along the atrial side of the mitral valve and mild mitral regurgitation because of prolapse of the anterior commissure. Methicillin-sensitive Staphylococcus aureus was identified in the blood cultures. Detection of distinctive skin lesions, so-called Osler’s nodes, was the symptomatic key to early diagnosis, and the patient was treated without surgery. She was discharged with negative blood cultures after a 6-week intravenous antibiotic administration. Conclusions Our report highlights the importance of considering the risk of extracerebral infections including endocarditis in hemorrhagic telangiectasia. This rare case effectively demonstrates the importance of proper diagnosis of skin lesions. |
| first_indexed | 2024-12-12T06:08:43Z |
| format | Article |
| id | doaj.art-f25e4f7b8bd44c19b6efd980b4a29867 |
| institution | Directory Open Access Journal |
| issn | 1752-1947 |
| language | English |
| last_indexed | 2024-12-12T06:08:43Z |
| publishDate | 2022-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Medical Case Reports |
| spelling | doaj.art-f25e4f7b8bd44c19b6efd980b4a298672022-12-22T00:35:13ZengBMCJournal of Medical Case Reports1752-19472022-05-011611410.1186/s13256-022-03427-2Infective endocarditis with Osler’s nodule in a patient with Osler’s disease: a case report and review of the literatureGenki Naruse0Takatomo Watanabe1Hiroyuki Okura2Department of Cardiology, Gifu University Graduate School of MedicineDepartment of Cardiology, Gifu University Graduate School of MedicineDepartment of Cardiology, Gifu University Graduate School of MedicineAbstract Background Hereditary hemorrhagic telangiectasia, also known as Osler–Weber–Rendu disease, induces arteriovenous malformations in visceral organs. Arteriovenous malformations increase the risk of severe infections and are a common complication associated with hemorrhagic telangiectasia. However, cases of endocarditis associated with hemorrhagic telangiectasia are rarely reported. Although hemorrhagic telangiectasia causes erythematous macules on the extremities, these macules are usually painless. We encountered a rare case of infective endocarditis in a patient with Osler–Weber–Rendu disease. Case presentation A 52-year-old Japanese woman who was diagnosed with hemorrhagic telangiectasia 5 years prior presented to our hospital with fever and muscular pain. She had erythematous nodules and tenderness on the finger, heel, and toe, suggestive of Osler’s nodes. A physical examination revealed tachycardia with a 3/6 pansystolic murmur. A transesophageal echocardiogram showed vegetations along the atrial side of the mitral valve and mild mitral regurgitation because of prolapse of the anterior commissure. Methicillin-sensitive Staphylococcus aureus was identified in the blood cultures. Detection of distinctive skin lesions, so-called Osler’s nodes, was the symptomatic key to early diagnosis, and the patient was treated without surgery. She was discharged with negative blood cultures after a 6-week intravenous antibiotic administration. Conclusions Our report highlights the importance of considering the risk of extracerebral infections including endocarditis in hemorrhagic telangiectasia. This rare case effectively demonstrates the importance of proper diagnosis of skin lesions.https://doi.org/10.1186/s13256-022-03427-2Extracerebral infectionsHereditary hemorrhagic telangiectasiaInfective endocarditisOsler–Weber–Rendu diseaseSkin lesionsCase report |
| spellingShingle | Genki Naruse Takatomo Watanabe Hiroyuki Okura Infective endocarditis with Osler’s nodule in a patient with Osler’s disease: a case report and review of the literature Journal of Medical Case Reports Extracerebral infections Hereditary hemorrhagic telangiectasia Infective endocarditis Osler–Weber–Rendu disease Skin lesions Case report |
| title | Infective endocarditis with Osler’s nodule in a patient with Osler’s disease: a case report and review of the literature |
| title_full | Infective endocarditis with Osler’s nodule in a patient with Osler’s disease: a case report and review of the literature |
| title_fullStr | Infective endocarditis with Osler’s nodule in a patient with Osler’s disease: a case report and review of the literature |
| title_full_unstemmed | Infective endocarditis with Osler’s nodule in a patient with Osler’s disease: a case report and review of the literature |
| title_short | Infective endocarditis with Osler’s nodule in a patient with Osler’s disease: a case report and review of the literature |
| title_sort | infective endocarditis with osler s nodule in a patient with osler s disease a case report and review of the literature |
| topic | Extracerebral infections Hereditary hemorrhagic telangiectasia Infective endocarditis Osler–Weber–Rendu disease Skin lesions Case report |
| url | https://doi.org/10.1186/s13256-022-03427-2 |
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