Mild behavioral impairment correlates of cognitive impairments in older adults without dementia: mediation by amyloid pathology
Abstract The relationship between mild behavioral impairment (MBI) and Alzheimer’s disease (AD) is intricate and still not well investigated. The purpose of the study is to examine the roles of the AD imaging pathologies in modulating the associations of MBI with cognitive impairments. We analyzed 1...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2021-11-01
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| Series: | Translational Psychiatry |
| Online Access: | https://doi.org/10.1038/s41398-021-01675-2 |
| _version_ | 1818913823658082304 |
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| author | Yan Sun Wei Xu Ke-Liang Chen Xue-Ning Shen Lan Tan Jin-Tai Yu for the Alzheimer’s Disease Neuroimaging Initiative |
| author_facet | Yan Sun Wei Xu Ke-Liang Chen Xue-Ning Shen Lan Tan Jin-Tai Yu for the Alzheimer’s Disease Neuroimaging Initiative |
| author_sort | Yan Sun |
| collection | DOAJ |
| description | Abstract The relationship between mild behavioral impairment (MBI) and Alzheimer’s disease (AD) is intricate and still not well investigated. The purpose of the study is to examine the roles of the AD imaging pathologies in modulating the associations of MBI with cognitive impairments. We analyzed 1129 participants (563 [49.86%] female), who had measures of Neuropsychiatric Inventory Questionnaire (NPI-Q), cognition, and amyloid PET AD biomarkers from the Alzheimer’s disease Neuroimaging Initiative (ADNI). We assess the longitudinal neuropathological and clinical correlates of baseline MBI via linear mixed effects and Cox proportional hazard models. The mediation analyses were used to test the mediation effects of AD pathologies on cognition. We found that MBI was associated with worse global cognition as represented by Mini-Mental State Examination (MMSE) (p < 0.001), and higher β-amyloid burden (p < 0.001). β-amyloid partially mediated the effects of MBI on cognition with the mediation percentage varied from 14.67 to 40.86% for general cognition, memory, executive, and language functions for non-dementia individuals. However, no significant associations were discovered between MBI and tau burden or neurodegeneration. Furthermore, longitudinal analyses revealed that individuals with MBI had a faster increase in brain amyloid burden (p < 0.001) and a higher risk of clinical conversion (HR = 2.42, 95% CI = 1.45 to 4.01 p < 0.001). In conclusion, MBI could be an imperative prediction indicator of clinical and pathological progression. In addition, amyloid pathologies might partially mediate the influences of MBI on cognitive impairments and AD risk. |
| first_indexed | 2024-12-19T23:36:37Z |
| format | Article |
| id | doaj.art-f25f5534363148629779ac8f6b828515 |
| institution | Directory Open Access Journal |
| issn | 2158-3188 |
| language | English |
| last_indexed | 2024-12-19T23:36:37Z |
| publishDate | 2021-11-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Translational Psychiatry |
| spelling | doaj.art-f25f5534363148629779ac8f6b8285152022-12-21T20:01:35ZengNature Publishing GroupTranslational Psychiatry2158-31882021-11-011111810.1038/s41398-021-01675-2Mild behavioral impairment correlates of cognitive impairments in older adults without dementia: mediation by amyloid pathologyYan Sun0Wei Xu1Ke-Liang Chen2Xue-Ning Shen3Lan Tan4Jin-Tai Yu5for the Alzheimer’s Disease Neuroimaging InitiativeDepartment of Neurology, Qingdao Municipal Hospital, Qingdao UniversityDepartment of Neurology, Qingdao Municipal Hospital, Qingdao UniversityDepartment of Neurology and Institute of Neurology, Huashan Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Shanghai Medical College, Fudan UniversityDepartment of Neurology and Institute of Neurology, Huashan Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Shanghai Medical College, Fudan UniversityDepartment of Neurology, Qingdao Municipal Hospital, Qingdao UniversityDepartment of Neurology and Institute of Neurology, Huashan Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Shanghai Medical College, Fudan UniversityAbstract The relationship between mild behavioral impairment (MBI) and Alzheimer’s disease (AD) is intricate and still not well investigated. The purpose of the study is to examine the roles of the AD imaging pathologies in modulating the associations of MBI with cognitive impairments. We analyzed 1129 participants (563 [49.86%] female), who had measures of Neuropsychiatric Inventory Questionnaire (NPI-Q), cognition, and amyloid PET AD biomarkers from the Alzheimer’s disease Neuroimaging Initiative (ADNI). We assess the longitudinal neuropathological and clinical correlates of baseline MBI via linear mixed effects and Cox proportional hazard models. The mediation analyses were used to test the mediation effects of AD pathologies on cognition. We found that MBI was associated with worse global cognition as represented by Mini-Mental State Examination (MMSE) (p < 0.001), and higher β-amyloid burden (p < 0.001). β-amyloid partially mediated the effects of MBI on cognition with the mediation percentage varied from 14.67 to 40.86% for general cognition, memory, executive, and language functions for non-dementia individuals. However, no significant associations were discovered between MBI and tau burden or neurodegeneration. Furthermore, longitudinal analyses revealed that individuals with MBI had a faster increase in brain amyloid burden (p < 0.001) and a higher risk of clinical conversion (HR = 2.42, 95% CI = 1.45 to 4.01 p < 0.001). In conclusion, MBI could be an imperative prediction indicator of clinical and pathological progression. In addition, amyloid pathologies might partially mediate the influences of MBI on cognitive impairments and AD risk.https://doi.org/10.1038/s41398-021-01675-2 |
| spellingShingle | Yan Sun Wei Xu Ke-Liang Chen Xue-Ning Shen Lan Tan Jin-Tai Yu for the Alzheimer’s Disease Neuroimaging Initiative Mild behavioral impairment correlates of cognitive impairments in older adults without dementia: mediation by amyloid pathology Translational Psychiatry |
| title | Mild behavioral impairment correlates of cognitive impairments in older adults without dementia: mediation by amyloid pathology |
| title_full | Mild behavioral impairment correlates of cognitive impairments in older adults without dementia: mediation by amyloid pathology |
| title_fullStr | Mild behavioral impairment correlates of cognitive impairments in older adults without dementia: mediation by amyloid pathology |
| title_full_unstemmed | Mild behavioral impairment correlates of cognitive impairments in older adults without dementia: mediation by amyloid pathology |
| title_short | Mild behavioral impairment correlates of cognitive impairments in older adults without dementia: mediation by amyloid pathology |
| title_sort | mild behavioral impairment correlates of cognitive impairments in older adults without dementia mediation by amyloid pathology |
| url | https://doi.org/10.1038/s41398-021-01675-2 |
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