Mild behavioral impairment correlates of cognitive impairments in older adults without dementia: mediation by amyloid pathology

Mild behavioral impairment correlates of cognitive impairments in older adults without dementia: mediation by amyloid pathology

Abstract The relationship between mild behavioral impairment (MBI) and Alzheimer’s disease (AD) is intricate and still not well investigated. The purpose of the study is to examine the roles of the AD imaging pathologies in modulating the associations of MBI with cognitive impairments. We analyzed 1...

Full description

Bibliographic Details
Main Authors:	Yan Sun, Wei Xu, Ke-Liang Chen, Xue-Ning Shen, Lan Tan, Jin-Tai Yu, for the Alzheimer’s Disease Neuroimaging Initiative
Format:	Article
Language:	English
Published:	Nature Publishing Group 2021-11-01
Series:	Translational Psychiatry
Online Access:	https://doi.org/10.1038/s41398-021-01675-2

Similar Items

Language dysfunction correlates with cognitive impairments in older adults without dementia mediated by amyloid pathology
by: Chunchen Xiang, et al.
Published: (2023-05-01)

CSF TNF α levels were associated with conversion from mild cognitive impairment to dementia.
by: Pan Fu, et al.
Published: (2022-01-01)

Plasma adiponectin levels predict cognitive decline and cortical thinning in mild cognitive impairment with beta-amyloid pathology
by: Keun You Kim, et al.
Published: (2022-11-01)

Posterior atrophy predicts time to dementia in patients with amyloid-positive mild cognitive impairment
by: Jung-Min Pyun, et al.
Published: (2017-12-01)

FDG-PET hypermetabolism is associated with higher tau-PET in mild cognitive impairment at low amyloid-PET levels
by: Anna Rubinski, et al.
Published: (2020-10-01)

Distinct spatiotemporal subtypes of amyloid deposition are associated with diverging disease profiles in cognitively normal and mild cognitive impairment individuals
by: Yuqing Sun, et al.
Published: (2023-02-01)

The impact of subthreshold levels of amyloid deposition on conversion to dementia in patients with amyloid-negative amnestic mild cognitive impairment
by: Hyung-Ji Kim, et al.
Published: (2022-07-01)

Prognostic relevance of gait-related cognitive functions for dementia conversion in amnestic mild cognitive impairment
by: Cosimo Tuena, et al.
Published: (2023-07-01)

Random forest model for feature-based Alzheimer's disease conversion prediction from early mild cognitive impairment subjects.
by: Matthew Velazquez, et al.
Published: (2021-01-01)

Uncovering heterogeneous cognitive trajectories in mild cognitive impairment: a data-driven approach
by: Xiwu Wang, et al.
Published: (2023-03-01)

Dissociation between brain amyloid deposition and metabolism in early mild cognitive impairment.
by: Liyong Wu, et al.
Published: (2012-01-01)

Apolipoprotein E ε4 and ε3 alleles associate with cerebrospinal fluid tau and cognition in the presence of amyloid-𝜷 in mild cognitive impairment but not in Alzheimer’s disease
by: Feng Xing, et al.
Published: (2021-06-01)

A combination of 3-D discrete wavelet transform and 3-D local binary pattern for classification of mild cognitive impairment
by: Harsh Bhasin, et al.
Published: (2020-02-01)

Lower functional hippocampal redundancy in mild cognitive impairment
by: Stephanie Langella, et al.
Published: (2021-01-01)

Sex-dependent association of serum uric acid levels with amyloid accumulation among amyloid-positive older adults.
by: Guanan Zhao, et al.
Published: (2024-01-01)

Prevalence of Alzheimer's pathologic endophenotypes in asymptomatic and mildly impaired first-degree relatives.
by: Erika J Lampert, et al.
Published: (2013-01-01)

The Effect of the APOE Genotype on Individual BrainAGE in Normal Aging, Mild Cognitive Impairment, and Alzheimer's Disease.
by: Luise Christine Löwe, et al.
Published: (2016-01-01)

Associations between Neuropsychiatric Symptoms and Alzheimer’s Disease Biomarkers in People with Mild Cognitive Impairment
by: Giulia Arenare, et al.
Published: (2023-08-01)

Item-Level Scores on the Boston Naming Test as an Independent Predictor of Perirhinal Volume in Individuals with Mild Cognitive Impairment
by: Matteo De Marco, et al.
Published: (2023-05-01)

Mild-moderate CKD is not associated with cognitive impairment in older adults in the Alzheimer's Disease Neuroimaging Initiative cohort.
by: Aditi Gupta, et al.
Published: (2020-01-01)

Predictability of polygenic risk score for progression to dementia and its interaction with APOE ε4 in mild cognitive impairment
by: Jung-Min Pyun, et al.
Published: (2021-08-01)

Neurofilament light as a biomarker of axonal degeneration in patients with mild cognitive impairment and Alzheimer’s disease
by: Yi Chen, et al.
Published: (2021-12-01)

Deep multiview learning to identify imaging-driven subtypes in mild cognitive impairment
by: Yixue Feng, et al.
Published: (2022-09-01)

The Relationship Between Hippocampal Volumes and Delayed Recall Is Modified by APOE ε4 in Mild Cognitive Impairment
by: Xiwu Wang, et al.
Published: (2019-02-01)

Pathological correlates of impaired self-awareness of memory function in Alzheimer’s disease
by: Geoffroy Gagliardi, et al.
Published: (2021-06-01)

Practical algorithms for amyloid β probability in subjective or mild cognitive impairment
by: Nancy Maserejian, et al.
Published: (2019-12-01)

Association of CSF GAP-43 and <i>APOE</i> ε4 with Cognition in Mild Cognitive Impairment and Alzheimer’s Disease
by: Yueli Zhu, et al.
Published: (2022-12-01)

Brain network alterations in individuals with and without mild cognitive impairment: parallel independent component analysis of AV1451 and AV45 positron emission tomography
by: Yuan Li, et al.
Published: (2019-06-01)

The personalized Alzheimer's disease cortical thickness index predicts likely pathology and clinical progression in mild cognitive impairment
by: Annie M. Racine, et al.
Published: (2018-01-01)

Evaluating trajectories of episodic memory in normal cognition and mild cognitive impairment: Results from ADNI.
by: Xiuhua Ding, et al.
Published: (2019-01-01)

Brain network construction and analysis for patients with mild cognitive impairment and Alzheimer's disease based on a highly‐available nodes approach
by: Xiaopan Zhang, et al.
Published: (2021-03-01)

Quantification of cognitive impairment to characterize heterogeneity of patients at risk of developing Alzheimer's disease dementia
by: Diana L. Giraldo, et al.
Published: (2021-01-01)

Age, vascular disease, and Alzheimer’s disease pathologies in amyloid negative elderly adults
by: Tengfei Guo, et al.
Published: (2021-10-01)

NeuropsychBrainAge: A biomarker for conversion from mild cognitive impairment to Alzheimer's disease
by: Jorge Garcia Condado, et al.
Published: (2023-10-01)

Hippocampus-centred grey matter covariance networks predict the development and reversion of mild cognitive impairment
by: Mingxi Dang, et al.
Published: (2023-02-01)

Investigation on the Alteration of Brain Functional Network and Its Role in the Identification of Mild Cognitive Impairment
by: Lulu Zhang, et al.
Published: (2020-09-01)

Explainability of random survival forests in predicting conversion risk from mild cognitive impairment to Alzheimer’s disease
by: Alessia Sarica, et al.
Published: (2023-11-01)

Soluble TREM2 levels associate with conversion from mild cognitive impairment to Alzheimer’s disease
by: Aonan Zhao, et al.
Published: (2022-12-01)

Abnormal cortical networks in mild cognitive impairment and Alzheimer's disease.
by: Zhijun Yao, et al.
Published: (2010-11-01)

Information Flow Pattern in Early Mild Cognitive Impairment Patients
by: Haijuan He, et al.
Published: (2021-11-01)