Retinal Oxygen Extraction in Patients with Primary Open-Angle Glaucoma
Objective: To compare total retinal oxygen extraction between patients with primary open-angle glaucoma (POAG) and healthy control subjects. Design: A prospective, single-center, cross-sectional, case–control study performed at the Medical University of Vienna. Subjects: Forty patients with POAG and...
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MDPI AG
2022-09-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/17/10152 |
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| author | Gerhard Garhöfer Ahmed M. Bata Alina Popa-Cherecheanu Anton Hommer Clemens Vass Hemma Resch Doreen Schmidl René M. Werkmeister Leopold Schmetterer |
| author_facet | Gerhard Garhöfer Ahmed M. Bata Alina Popa-Cherecheanu Anton Hommer Clemens Vass Hemma Resch Doreen Schmidl René M. Werkmeister Leopold Schmetterer |
| author_sort | Gerhard Garhöfer |
| collection | DOAJ |
| description | Objective: To compare total retinal oxygen extraction between patients with primary open-angle glaucoma (POAG) and healthy control subjects. Design: A prospective, single-center, cross-sectional, case–control study performed at the Medical University of Vienna. Subjects: Forty patients with POAG and 40 age- and sex-matched control subjects. Methods: Total retinal blood flow was measured using Doppler optical coherence tomography (OCT). Retinal arterial and venous oxygen saturation was measured using reflectance spectroscopy. From these parameters, oxygen content in the retinal arterial and venous circulation as well as total retinal oxygen extraction were calculated. Results: Total retinal blood flow was lower in POAG (25.2 ± 6.7 µL/min) as compared to healthy control subjects (35.6 ± 8.3 µL/min, <i>p</i> < 0.001). Retinal arterial oxygen content was not different between the two groups (0.18 ± 0.01 mL(O2)/mL in both groups, <i>p</i> < 0.761), but retinal venous oxygen content was higher in POAG (0.15 ± 0.01 mL(O2)/mL) than in healthy controls (0.14 ± 0.01 mL(O2)/mL <i>p</i> < 0.001). Accordingly, retinal oxygen extraction was reduced in POAG (0.8 ± 0.3 µL(O2)/min as compared to healthy controls: 1.4 ± 0.4 µL(O2)/min, <i>p</i> < 0.001). There was a significant association between total retinal blood flow and total retinal oxygen extraction with measures of structural and functional damage (<i>p</i> < 0.001 each). Conclusions: This study indicates that POAG is associated with a reduction in total retinal oxygen extraction linked to structural and functional damage of the disease. Since the technology is non-invasive, it allows for longitudinal studies investigating to which degree low retinal oxygen extraction is linked to the progression of the disease. |
| first_indexed | 2024-03-10T01:41:52Z |
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| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T01:41:52Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-f260893b52084f8aa315310599dba5e52023-11-23T13:23:53ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-09-0123171015210.3390/ijms231710152Retinal Oxygen Extraction in Patients with Primary Open-Angle GlaucomaGerhard Garhöfer0Ahmed M. Bata1Alina Popa-Cherecheanu2Anton Hommer3Clemens Vass4Hemma Resch5Doreen Schmidl6René M. Werkmeister7Leopold Schmetterer8Department of Clinical Pharmacology, Medical University of Vienna, 1090 Vienna, AustriaDepartment of Clinical Pharmacology, Medical University of Vienna, 1090 Vienna, AustriaDepartment of Ophthalmology, Carol Davila University of Medicine and Pharmacy District 5, 020021 Bucharest, RomaniaDepartment of Clinical Pharmacology, Medical University of Vienna, 1090 Vienna, AustriaDepartment of Ophthalmology, Medical University of Vienna, 1090 Vienna, AustriaDepartment of Ophthalmology, Medical University of Vienna, 1090 Vienna, AustriaDepartment of Clinical Pharmacology, Medical University of Vienna, 1090 Vienna, AustriaCenter for Medical Physics and Biomedical Engineering, Medical University of Vienna, 1090 Vienna, AustriaDepartment of Clinical Pharmacology, Medical University of Vienna, 1090 Vienna, AustriaObjective: To compare total retinal oxygen extraction between patients with primary open-angle glaucoma (POAG) and healthy control subjects. Design: A prospective, single-center, cross-sectional, case–control study performed at the Medical University of Vienna. Subjects: Forty patients with POAG and 40 age- and sex-matched control subjects. Methods: Total retinal blood flow was measured using Doppler optical coherence tomography (OCT). Retinal arterial and venous oxygen saturation was measured using reflectance spectroscopy. From these parameters, oxygen content in the retinal arterial and venous circulation as well as total retinal oxygen extraction were calculated. Results: Total retinal blood flow was lower in POAG (25.2 ± 6.7 µL/min) as compared to healthy control subjects (35.6 ± 8.3 µL/min, <i>p</i> < 0.001). Retinal arterial oxygen content was not different between the two groups (0.18 ± 0.01 mL(O2)/mL in both groups, <i>p</i> < 0.761), but retinal venous oxygen content was higher in POAG (0.15 ± 0.01 mL(O2)/mL) than in healthy controls (0.14 ± 0.01 mL(O2)/mL <i>p</i> < 0.001). Accordingly, retinal oxygen extraction was reduced in POAG (0.8 ± 0.3 µL(O2)/min as compared to healthy controls: 1.4 ± 0.4 µL(O2)/min, <i>p</i> < 0.001). There was a significant association between total retinal blood flow and total retinal oxygen extraction with measures of structural and functional damage (<i>p</i> < 0.001 each). Conclusions: This study indicates that POAG is associated with a reduction in total retinal oxygen extraction linked to structural and functional damage of the disease. Since the technology is non-invasive, it allows for longitudinal studies investigating to which degree low retinal oxygen extraction is linked to the progression of the disease.https://www.mdpi.com/1422-0067/23/17/10152glaucomaretinal oxygen extractionretinal blood flowDoppler optical coherence tomography |
| spellingShingle | Gerhard Garhöfer Ahmed M. Bata Alina Popa-Cherecheanu Anton Hommer Clemens Vass Hemma Resch Doreen Schmidl René M. Werkmeister Leopold Schmetterer Retinal Oxygen Extraction in Patients with Primary Open-Angle Glaucoma International Journal of Molecular Sciences glaucoma retinal oxygen extraction retinal blood flow Doppler optical coherence tomography |
| title | Retinal Oxygen Extraction in Patients with Primary Open-Angle Glaucoma |
| title_full | Retinal Oxygen Extraction in Patients with Primary Open-Angle Glaucoma |
| title_fullStr | Retinal Oxygen Extraction in Patients with Primary Open-Angle Glaucoma |
| title_full_unstemmed | Retinal Oxygen Extraction in Patients with Primary Open-Angle Glaucoma |
| title_short | Retinal Oxygen Extraction in Patients with Primary Open-Angle Glaucoma |
| title_sort | retinal oxygen extraction in patients with primary open angle glaucoma |
| topic | glaucoma retinal oxygen extraction retinal blood flow Doppler optical coherence tomography |
| url | https://www.mdpi.com/1422-0067/23/17/10152 |
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