Consequences of Viral Infection and Cytokine Production During Pregnancy on Brain Development in Offspring
Infections during pregnancy can seriously damage fetal neurodevelopment by aberrantly activating the maternal immune system, directly impacting fetal neural cells. Increasing evidence suggests that these adverse impacts involve alterations in neural stem cell biology with long-term consequences for...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-04-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.816619/full |
| _version_ | 1818366497094893568 |
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| author | Daniela Elgueta Paola Murgas Paola Murgas Paola Murgas Erick Riquelme Erick Riquelme Erick Riquelme Guang Yang Guang Yang Guang Yang Gonzalo I. Cancino Gonzalo I. Cancino |
| author_facet | Daniela Elgueta Paola Murgas Paola Murgas Paola Murgas Erick Riquelme Erick Riquelme Erick Riquelme Guang Yang Guang Yang Guang Yang Gonzalo I. Cancino Gonzalo I. Cancino |
| author_sort | Daniela Elgueta |
| collection | DOAJ |
| description | Infections during pregnancy can seriously damage fetal neurodevelopment by aberrantly activating the maternal immune system, directly impacting fetal neural cells. Increasing evidence suggests that these adverse impacts involve alterations in neural stem cell biology with long-term consequences for offspring, including neurodevelopmental disorders such as autism spectrum disorder, schizophrenia, and cognitive impairment. Here we review how maternal infection with viruses such as Influenza A, Cytomegalovirus, and Zika during pregnancy can affect the brain development of offspring by promoting the release of maternal pro-inflammatory cytokines, triggering neuroinflammation of the fetal brain, and/or directly infecting fetal neural cells. In addition, we review insights into how these infections impact human brain development from studies with animal models and brain organoids. Finally, we discuss how maternal infection with SARS-CoV-2 may have consequences for neurodevelopment of the offspring. |
| first_indexed | 2024-12-13T22:37:06Z |
| format | Article |
| id | doaj.art-f260db29fc16426d9cea9eca740cc479 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-13T22:37:06Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-f260db29fc16426d9cea9eca740cc4792022-12-21T23:28:57ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-04-011310.3389/fimmu.2022.816619816619Consequences of Viral Infection and Cytokine Production During Pregnancy on Brain Development in OffspringDaniela Elgueta0Paola Murgas1Paola Murgas2Paola Murgas3Erick Riquelme4Erick Riquelme5Erick Riquelme6Guang Yang7Guang Yang8Guang Yang9Gonzalo I. Cancino10Gonzalo I. Cancino11Center for Integrative Biology, Facultad de Ciencias, Universidad Mayor, Santiago, ChileCenter for Integrative Biology, Facultad de Ciencias, Universidad Mayor, Santiago, ChileEscuela de Tecnología Médica, Facultad de Ciencias, Universidad Mayor, Santiago, ChileEscuela de Biotecnología, Facultad de Ciencias, Universidad Mayor, Santiago, ChileCenter for Integrative Biology, Facultad de Ciencias, Universidad Mayor, Santiago, ChileEscuela de Tecnología Médica, Facultad de Ciencias, Universidad Mayor, Santiago, ChileEscuela de Biotecnología, Facultad de Ciencias, Universidad Mayor, Santiago, ChileDepartment of Medical Genetics, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada Department of Biochemistry and Molecular Biology, Cumming School of Medicine, University of Calgary, Calgary, AB, CanadaAlberta Children’s Hospital Research Institute, Calgary, AB, CanadaCenter for Integrative Biology, Facultad de Ciencias, Universidad Mayor, Santiago, ChileEscuela de Biotecnología, Facultad de Ciencias, Universidad Mayor, Santiago, ChileInfections during pregnancy can seriously damage fetal neurodevelopment by aberrantly activating the maternal immune system, directly impacting fetal neural cells. Increasing evidence suggests that these adverse impacts involve alterations in neural stem cell biology with long-term consequences for offspring, including neurodevelopmental disorders such as autism spectrum disorder, schizophrenia, and cognitive impairment. Here we review how maternal infection with viruses such as Influenza A, Cytomegalovirus, and Zika during pregnancy can affect the brain development of offspring by promoting the release of maternal pro-inflammatory cytokines, triggering neuroinflammation of the fetal brain, and/or directly infecting fetal neural cells. In addition, we review insights into how these infections impact human brain development from studies with animal models and brain organoids. Finally, we discuss how maternal infection with SARS-CoV-2 may have consequences for neurodevelopment of the offspring.https://www.frontiersin.org/articles/10.3389/fimmu.2022.816619/fullmaternal infectionsviruscytokinesneuroinflammationneurodevelopmental disorderscortical development |
| spellingShingle | Daniela Elgueta Paola Murgas Paola Murgas Paola Murgas Erick Riquelme Erick Riquelme Erick Riquelme Guang Yang Guang Yang Guang Yang Gonzalo I. Cancino Gonzalo I. Cancino Consequences of Viral Infection and Cytokine Production During Pregnancy on Brain Development in Offspring Frontiers in Immunology maternal infections virus cytokines neuroinflammation neurodevelopmental disorders cortical development |
| title | Consequences of Viral Infection and Cytokine Production During Pregnancy on Brain Development in Offspring |
| title_full | Consequences of Viral Infection and Cytokine Production During Pregnancy on Brain Development in Offspring |
| title_fullStr | Consequences of Viral Infection and Cytokine Production During Pregnancy on Brain Development in Offspring |
| title_full_unstemmed | Consequences of Viral Infection and Cytokine Production During Pregnancy on Brain Development in Offspring |
| title_short | Consequences of Viral Infection and Cytokine Production During Pregnancy on Brain Development in Offspring |
| title_sort | consequences of viral infection and cytokine production during pregnancy on brain development in offspring |
| topic | maternal infections virus cytokines neuroinflammation neurodevelopmental disorders cortical development |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.816619/full |
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