A Rare Case of Posterior Fossa Tumor and Central Precocious Puberty: Case Presentation and Review of the Literature
Central precocious puberty (CPP) is a condition that causes early gonadotropin-dependent sexual development; CPP is idiopathic in girls in most cases, whereas more than 50% of boys have an identifiable etiology. We conducted a qualitative systematic review following the ENTREQ (enhancing transparenc...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-10-01
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| Series: | Neurology International |
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| Online Access: | https://www.mdpi.com/2035-8377/13/4/53 |
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| author | Roberta Rana Teresa Perillo Nicola Santoro Federica Ortolani Raffaella Messina Mariachiara Resta Ilenia Perrucci Giuseppe Ingravallo Gerardo Cazzato Massimo Grassi Sabino Pesce Francesco Signorelli |
| author_facet | Roberta Rana Teresa Perillo Nicola Santoro Federica Ortolani Raffaella Messina Mariachiara Resta Ilenia Perrucci Giuseppe Ingravallo Gerardo Cazzato Massimo Grassi Sabino Pesce Francesco Signorelli |
| author_sort | Roberta Rana |
| collection | DOAJ |
| description | Central precocious puberty (CPP) is a condition that causes early gonadotropin-dependent sexual development; CPP is idiopathic in girls in most cases, whereas more than 50% of boys have an identifiable etiology. We conducted a qualitative systematic review following the ENTREQ (enhancing transparency in reporting the synthesis of qualitative research) framework. A search was made in MEDLINE/Pubmed and MeSH Database using the terms “precocious puberty” AND “brain tumor” OR “posterior fossa tumor” OR “cerebellar tumor” OR “infratentorial tumor”, identifying five cases of pediatric patients with infratentorial tumors and CPP and a case of cerebellar ganglioglioma without hypothalamic−pituitary−gonadal axis involvement and/or intracranial hypertension. Our work highlights the importance of a multidisciplinary approach and extensive central nervous system imaging for patients presenting with CPP in order to detect possible tumor association. Moreover, we believe that this manuscript could contribute to stimulate other research because the exact mechanism of CPP in infratentorial brain lesions has not been understood yet. |
| first_indexed | 2024-03-10T03:25:54Z |
| format | Article |
| id | doaj.art-f26577277c324d4e9e8ccddb2a0d741e |
| institution | Directory Open Access Journal |
| issn | 2035-8377 |
| language | English |
| last_indexed | 2024-03-10T03:25:54Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Neurology International |
| spelling | doaj.art-f26577277c324d4e9e8ccddb2a0d741e2023-11-23T09:53:26ZengMDPI AGNeurology International2035-83772021-10-0113453554010.3390/neurolint13040053A Rare Case of Posterior Fossa Tumor and Central Precocious Puberty: Case Presentation and Review of the LiteratureRoberta Rana0Teresa Perillo1Nicola Santoro2Federica Ortolani3Raffaella Messina4Mariachiara Resta5Ilenia Perrucci6Giuseppe Ingravallo7Gerardo Cazzato8Massimo Grassi9Sabino Pesce10Francesco Signorelli11Department of Pediatric Oncology and Hematology, University “Aldo Moro” of Bari, 70124 Bari, ItalyDepartment of Pediatric Oncology and Hematology, University “Aldo Moro” of Bari, 70124 Bari, ItalyDepartment of Pediatric Oncology and Hematology, University “Aldo Moro” of Bari, 70124 Bari, ItalyDepartment of Metabolic Diseases, Clinical Genetics and Diabetology, Giovanni XXIII Children’s Hospital, 70124 Bari, ItalyDivision of Neurosurgery, Department of Basic Medical Sciences, Neurosciences and Sense Organs, University “Aldo Moro” of Bari, 70124 Bari, ItalyDivision of Neuroradiology, Department of Basic Medical Sciences, Neurosciences and Sense Organs, University “Aldo Moro” of Bari, 70124 Bari, ItalyDivision of Neuroradiology, Department of Basic Medical Sciences, Neurosciences and Sense Organs, University “Aldo Moro” of Bari, 70124 Bari, ItalyDepartment of Emergency and Organ Transplantation—Section of Pathology, University “Aldo Moro” of Bari, 70124 Bari, ItalyDepartment of Emergency and Organ Transplantation—Section of Pathology, University “Aldo Moro” of Bari, 70124 Bari, ItalyDepartment of Pediatric Oncology and Hematology, University “Aldo Moro” of Bari, 70124 Bari, ItalyDepartment of Metabolic Diseases, Clinical Genetics and Diabetology, Giovanni XXIII Children’s Hospital, 70124 Bari, ItalyDivision of Neurosurgery, Department of Basic Medical Sciences, Neurosciences and Sense Organs, University “Aldo Moro” of Bari, 70124 Bari, ItalyCentral precocious puberty (CPP) is a condition that causes early gonadotropin-dependent sexual development; CPP is idiopathic in girls in most cases, whereas more than 50% of boys have an identifiable etiology. We conducted a qualitative systematic review following the ENTREQ (enhancing transparency in reporting the synthesis of qualitative research) framework. A search was made in MEDLINE/Pubmed and MeSH Database using the terms “precocious puberty” AND “brain tumor” OR “posterior fossa tumor” OR “cerebellar tumor” OR “infratentorial tumor”, identifying five cases of pediatric patients with infratentorial tumors and CPP and a case of cerebellar ganglioglioma without hypothalamic−pituitary−gonadal axis involvement and/or intracranial hypertension. Our work highlights the importance of a multidisciplinary approach and extensive central nervous system imaging for patients presenting with CPP in order to detect possible tumor association. Moreover, we believe that this manuscript could contribute to stimulate other research because the exact mechanism of CPP in infratentorial brain lesions has not been understood yet.https://www.mdpi.com/2035-8377/13/4/53CPPgangliogliomaSNCneuroradiology |
| spellingShingle | Roberta Rana Teresa Perillo Nicola Santoro Federica Ortolani Raffaella Messina Mariachiara Resta Ilenia Perrucci Giuseppe Ingravallo Gerardo Cazzato Massimo Grassi Sabino Pesce Francesco Signorelli A Rare Case of Posterior Fossa Tumor and Central Precocious Puberty: Case Presentation and Review of the Literature Neurology International CPP ganglioglioma SNC neuroradiology |
| title | A Rare Case of Posterior Fossa Tumor and Central Precocious Puberty: Case Presentation and Review of the Literature |
| title_full | A Rare Case of Posterior Fossa Tumor and Central Precocious Puberty: Case Presentation and Review of the Literature |
| title_fullStr | A Rare Case of Posterior Fossa Tumor and Central Precocious Puberty: Case Presentation and Review of the Literature |
| title_full_unstemmed | A Rare Case of Posterior Fossa Tumor and Central Precocious Puberty: Case Presentation and Review of the Literature |
| title_short | A Rare Case of Posterior Fossa Tumor and Central Precocious Puberty: Case Presentation and Review of the Literature |
| title_sort | rare case of posterior fossa tumor and central precocious puberty case presentation and review of the literature |
| topic | CPP ganglioglioma SNC neuroradiology |
| url | https://www.mdpi.com/2035-8377/13/4/53 |
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