Prematurity and brain perfusion: Arterial spin labeling MRI
Purpose: Abnormal brain perfusion is a critical mechanism in neonatal brain injury. The aim of the present study was to compare Cerebral Blood Flow (CBF) evaluated with ASL MRI in three groups of neonates: preterms without brain lesions on MRI (PN), preterms with periventricular white matter lesions...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2017-01-01
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| Series: | NeuroImage: Clinical |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213158217301286 |
| _version_ | 1828518575521923072 |
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| author | Domenico Tortora Peter Angelo Mattei Riccardo Navarra Valentina Panara Rita Salomone Andrea Rossi John A. Detre Massimo Caulo |
| author_facet | Domenico Tortora Peter Angelo Mattei Riccardo Navarra Valentina Panara Rita Salomone Andrea Rossi John A. Detre Massimo Caulo |
| author_sort | Domenico Tortora |
| collection | DOAJ |
| description | Purpose: Abnormal brain perfusion is a critical mechanism in neonatal brain injury. The aim of the present study was to compare Cerebral Blood Flow (CBF) evaluated with ASL MRI in three groups of neonates: preterms without brain lesions on MRI (PN), preterms with periventricular white matter lesions (PNp) and term neonates with normal MRI (TN). The correlation between CBF and clinical outcome was explored. Materials and methods: The institutional review board approved this prospective study and waived informed consent. The perfusion ASL data from 49 consecutive preterm neonates (PN) studied at term-equivalent age and 15 TN were evaluated. Statistically significant differences in gray matter CBF were evaluated by using a linear mixed-model analysis and Mann-Whitney U test. Logistic regression analysis was used to assess the relation between CBF and neuromotor outcome at 12months. Results: Comparison of means indicated that the CBF of the whole brain were significantly higher in PN compared to TN (P=0.011). This difference remained significant when considering the frontal (P=0.038), parietal (P=0.002), temporal (P=0.030), occipital (P=0.041) and cerebellar (P=0.010) gray matter. In the PN group, lower CBF in basal ganglia was associated with a worse neuromotor outcome (P=0.012). Conclusions: ASL MRI demonstrated differences in brain perfusion of the basal ganglia between PN and TN. In PN, a positive correlation between CBF and neuromotor outcome was demonstrated in this area. Keywords: Brain perfusion, Neonate, Prematurity |
| first_indexed | 2024-12-11T18:57:22Z |
| format | Article |
| id | doaj.art-f2688378a5444535a35e500dcf46e989 |
| institution | Directory Open Access Journal |
| issn | 2213-1582 |
| language | English |
| last_indexed | 2024-12-11T18:57:22Z |
| publishDate | 2017-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage: Clinical |
| spelling | doaj.art-f2688378a5444535a35e500dcf46e9892022-12-22T00:54:06ZengElsevierNeuroImage: Clinical2213-15822017-01-0115401407Prematurity and brain perfusion: Arterial spin labeling MRIDomenico Tortora0Peter Angelo Mattei1Riccardo Navarra2Valentina Panara3Rita Salomone4Andrea Rossi5John A. Detre6Massimo Caulo7ITAB—Institute of Advanced Biomedical Technologies, University “G. d'Annunzio”, Via Luigi Polacchi 11, 66100 Chieti, Italy; Neuroradiology Unit, Istituto Giannina Gaslini, Via Gerolamo Gaslini 5, 16147 Genoa, ItalyOphthalmology Clinic, Department of Medicine and Aging Sciences, University “G. d'Annunzio”, Via dei Vestini, 66100 Chieti, ItalyITAB—Institute of Advanced Biomedical Technologies, University “G. d'Annunzio”, Via Luigi Polacchi 11, 66100 Chieti, Italy; Department of Neuroscience and Imaging, University “G. d'Annunzio”, Via dei Vestini, 66100 Chieti, ItalyITAB—Institute of Advanced Biomedical Technologies, University “G. d'Annunzio”, Via Luigi Polacchi 11, 66100 Chieti, Italy; Department of Neuroscience and Imaging, University “G. d'Annunzio”, Via dei Vestini, 66100 Chieti, ItalyDepartment of Paediatrics, Neonatology and Neonatal Intensive Care Unit, University Hospital of Chieti, Via dei Vestini, 66100 Chieti, ItalyNeuroradiology Unit, Istituto Giannina Gaslini, Via Gerolamo Gaslini 5, 16147 Genoa, ItalyDepartment of Neurology, University of Pennsylvania Perelman School of Medicine, 3400 Spruce Street, Philadelphia, PA 19104, USAITAB—Institute of Advanced Biomedical Technologies, University “G. d'Annunzio”, Via Luigi Polacchi 11, 66100 Chieti, Italy; Department of Neuroscience and Imaging, University “G. d'Annunzio”, Via dei Vestini, 66100 Chieti, Italy; Corresponding author at: ITAB — Institute of Advanced Biomedical Technologies, University “G. d'Annunzio”, Via Luigi Polacchi 11, 66100 Chieti, Italy.Purpose: Abnormal brain perfusion is a critical mechanism in neonatal brain injury. The aim of the present study was to compare Cerebral Blood Flow (CBF) evaluated with ASL MRI in three groups of neonates: preterms without brain lesions on MRI (PN), preterms with periventricular white matter lesions (PNp) and term neonates with normal MRI (TN). The correlation between CBF and clinical outcome was explored. Materials and methods: The institutional review board approved this prospective study and waived informed consent. The perfusion ASL data from 49 consecutive preterm neonates (PN) studied at term-equivalent age and 15 TN were evaluated. Statistically significant differences in gray matter CBF were evaluated by using a linear mixed-model analysis and Mann-Whitney U test. Logistic regression analysis was used to assess the relation between CBF and neuromotor outcome at 12months. Results: Comparison of means indicated that the CBF of the whole brain were significantly higher in PN compared to TN (P=0.011). This difference remained significant when considering the frontal (P=0.038), parietal (P=0.002), temporal (P=0.030), occipital (P=0.041) and cerebellar (P=0.010) gray matter. In the PN group, lower CBF in basal ganglia was associated with a worse neuromotor outcome (P=0.012). Conclusions: ASL MRI demonstrated differences in brain perfusion of the basal ganglia between PN and TN. In PN, a positive correlation between CBF and neuromotor outcome was demonstrated in this area. Keywords: Brain perfusion, Neonate, Prematurityhttp://www.sciencedirect.com/science/article/pii/S2213158217301286 |
| spellingShingle | Domenico Tortora Peter Angelo Mattei Riccardo Navarra Valentina Panara Rita Salomone Andrea Rossi John A. Detre Massimo Caulo Prematurity and brain perfusion: Arterial spin labeling MRI NeuroImage: Clinical |
| title | Prematurity and brain perfusion: Arterial spin labeling MRI |
| title_full | Prematurity and brain perfusion: Arterial spin labeling MRI |
| title_fullStr | Prematurity and brain perfusion: Arterial spin labeling MRI |
| title_full_unstemmed | Prematurity and brain perfusion: Arterial spin labeling MRI |
| title_short | Prematurity and brain perfusion: Arterial spin labeling MRI |
| title_sort | prematurity and brain perfusion arterial spin labeling mri |
| url | http://www.sciencedirect.com/science/article/pii/S2213158217301286 |
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