Trypanocidal activity of Meliaceae and Rutaceae plant extracts
The in vitro trypanocidal activity of 22 extracts and 43 fractions of plants belonging to the families Meliaceae and Rutaceae was evaluated. The extracts from leaves of Conchocarphus heterophyllus and branches of Trichilia ramalhoi were the most active. The trypanocidal activity seems to be increase...
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| Format: | Article |
| Language: | English |
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Fundação Oswaldo Cruz (FIOCRUZ)
2004-03-01
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| Series: | Memorias do Instituto Oswaldo Cruz |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762004000200020 |
| _version_ | 1797757147104149504 |
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| author | Alessandra Regina Pepe Ambrozin Paulo Cezar Vieira João Batista Fernandes Maria Fátima das Graças Fernandes da Silva Sérgio de Albuquerque |
| author_facet | Alessandra Regina Pepe Ambrozin Paulo Cezar Vieira João Batista Fernandes Maria Fátima das Graças Fernandes da Silva Sérgio de Albuquerque |
| author_sort | Alessandra Regina Pepe Ambrozin |
| collection | DOAJ |
| description | The in vitro trypanocidal activity of 22 extracts and 43 fractions of plants belonging to the families Meliaceae and Rutaceae was evaluated. The extracts from leaves of Conchocarphus heterophyllus and branches of Trichilia ramalhoi were the most active. The trypanocidal activity seems to be increased by fractionation of the extracts. Fractions from C. heterophyllus and Galipea carinata were the most active and a 100% lysis of the parasites was observed for five fractions. From one of them were isolated two flavonoids: flavone and 7-methoxyflavone, which showed weak trypanocidal activity. The results obtained from the extracts and fractions revealed that the order Rutales is a promising source for the search of new drugs for Chagas disease. Phytochemical studies with the other active fractions are underway in order to isolate compounds, which could be associated with observed activities. |
| first_indexed | 2024-03-12T18:11:48Z |
| format | Article |
| id | doaj.art-f268a0ae172544c9a924249791e62295 |
| institution | Directory Open Access Journal |
| issn | 0074-0276 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T18:11:48Z |
| publishDate | 2004-03-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-f268a0ae172544c9a924249791e622952023-08-02T09:15:33ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz0074-02761678-80602004-03-0199222723110.1590/S0074-02762004000200020Trypanocidal activity of Meliaceae and Rutaceae plant extractsAlessandra Regina Pepe AmbrozinPaulo Cezar VieiraJoão Batista FernandesMaria Fátima das Graças Fernandes da SilvaSérgio de AlbuquerqueThe in vitro trypanocidal activity of 22 extracts and 43 fractions of plants belonging to the families Meliaceae and Rutaceae was evaluated. The extracts from leaves of Conchocarphus heterophyllus and branches of Trichilia ramalhoi were the most active. The trypanocidal activity seems to be increased by fractionation of the extracts. Fractions from C. heterophyllus and Galipea carinata were the most active and a 100% lysis of the parasites was observed for five fractions. From one of them were isolated two flavonoids: flavone and 7-methoxyflavone, which showed weak trypanocidal activity. The results obtained from the extracts and fractions revealed that the order Rutales is a promising source for the search of new drugs for Chagas disease. Phytochemical studies with the other active fractions are underway in order to isolate compounds, which could be associated with observed activities.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762004000200020MeliaceaeRutaceaeChagas diseasetrypanocidal activity |
| spellingShingle | Alessandra Regina Pepe Ambrozin Paulo Cezar Vieira João Batista Fernandes Maria Fátima das Graças Fernandes da Silva Sérgio de Albuquerque Trypanocidal activity of Meliaceae and Rutaceae plant extracts Memorias do Instituto Oswaldo Cruz Meliaceae Rutaceae Chagas disease trypanocidal activity |
| title | Trypanocidal activity of Meliaceae and Rutaceae plant extracts |
| title_full | Trypanocidal activity of Meliaceae and Rutaceae plant extracts |
| title_fullStr | Trypanocidal activity of Meliaceae and Rutaceae plant extracts |
| title_full_unstemmed | Trypanocidal activity of Meliaceae and Rutaceae plant extracts |
| title_short | Trypanocidal activity of Meliaceae and Rutaceae plant extracts |
| title_sort | trypanocidal activity of meliaceae and rutaceae plant extracts |
| topic | Meliaceae Rutaceae Chagas disease trypanocidal activity |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762004000200020 |
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