Impact of the MDM2 splice-variants MDM2-A, MDM2-B and MDM2-C on cytotoxic stress response in breast cancer cells

Impact of the MDM2 splice-variants MDM2-A, MDM2-B and MDM2-C on cytotoxic stress response in breast cancer cells

Abstract Background The murine double minute 2 (MDM2) is an oncogene and a negative regulator of the tumor suppressor protein p53. MDM2 is known to be amplified in numerous human cancers, and upregulation of MDM2 is considered to be an alternative mechanism of p53 inactivation. The presence of many...

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Bibliographic Details
Main Authors: Johanna Huun, Liv B. Gansmo, Bård Mannsåker, Gjertrud Titlestad Iversen, Jan Inge Øvrebø, Per E. Lønning, Stian Knappskog
Format: Article
Language:English
Published: BMC 2017-04-01
Series:BMC Cell Biology
Subjects:
MDM2
MDM2 splice variants
MDM2-A
MDM2-B
MDM2-C
Breast cancer
Online Access:http://link.springer.com/article/10.1186/s12860-017-0134-z

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