The Effect of Different Regimens of Vaccination against Pneumococcal Infection on the Clinical Course of Chronic Obstructive Pulmonary Disease: Focus on Changes in Sputum Microorganism Population
The objective: development of the best vaccination regimen against pneumococcal infection in patients with chronic obstructive pulmonary disease (COPD) with consideration of changes in microbiological and clinical parameters.Subjects and Methods. 115 patients with COPD were randomized into 4 pneumoc...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
New Terra Publishing House
2021-08-01
|
| Series: | Туберкулез и болезни лёгких |
| Subjects: | |
| Online Access: | https://www.tibl-journal.com/jour/article/view/1550 |
| _version_ | 1797700622544273408 |
|---|---|
| author | M. P. Kostinov А. D. Protasov А. V. Zhetkov M. L. Shteyner Yu. V. Tezikov I. S. Lipatov |
| author_facet | M. P. Kostinov А. D. Protasov А. V. Zhetkov M. L. Shteyner Yu. V. Tezikov I. S. Lipatov |
| author_sort | M. P. Kostinov |
| collection | DOAJ |
| description | The objective: development of the best vaccination regimen against pneumococcal infection in patients with chronic obstructive pulmonary disease (COPD) with consideration of changes in microbiological and clinical parameters.Subjects and Methods. 115 patients with COPD were randomized into 4 pneumococcal vaccination groups, they were examined and followed up for 4 years; 112 patients completed the study complying with the protocol. Detail medical history of all subjects was collected. To verify the diagnosis of COPD, all subjects underwent external respiratory function test and bronchodilator test (salbutamol, 400 μg) according to the standard method. The classic microbiological assessment was used in this study. The clinical effectiveness of vaccination was assessed. Statistical processing of the results was performed using StatPlus Pro 6.2.0.0 software (license number 2883).Results. Сonsecutive vaccination with pneumococcal conjugate and polysaccharide vaccines leads to decreased isolation rate of pneuniococcus from the sputum of CODP patients. The frequency of exacerbations, the need for antibiotic chemotherapy and hospitalizations also goes down. |
| first_indexed | 2024-03-12T04:24:29Z |
| format | Article |
| id | doaj.art-f26a4ca8842a42afa650e275e75767a2 |
| institution | Directory Open Access Journal |
| issn | 2075-1230 2542-1506 |
| language | Russian |
| last_indexed | 2024-03-12T04:24:29Z |
| publishDate | 2021-08-01 |
| publisher | New Terra Publishing House |
| record_format | Article |
| series | Туберкулез и болезни лёгких |
| spelling | doaj.art-f26a4ca8842a42afa650e275e75767a22023-09-03T10:32:17ZrusNew Terra Publishing HouseТуберкулез и болезни лёгких2075-12302542-15062021-08-0199771710.21292/2075-1230-2021-99-7-7-171547The Effect of Different Regimens of Vaccination against Pneumococcal Infection on the Clinical Course of Chronic Obstructive Pulmonary Disease: Focus on Changes in Sputum Microorganism PopulationM. P. Kostinov0А. D. Protasov1А. V. Zhetkov2M. L. Shteyner3Yu. V. Tezikov4I. S. Lipatov5ФГБНУ «НИИ вакцин и сывороток им. И. И. Мечникова»ФГБОУ ВО «Самарский государственный медицинский университет» МЗ РФФГБОУ ВО «Самарский государственный медицинский университет» МЗ РФФГБОУ ВО «Самарский государственный медицинский университет» МЗ РФФГБОУ ВО «Самарский государственный медицинский университет» МЗ РФФГБОУ ВО «Самарский государственный медицинский университет» МЗ РФThe objective: development of the best vaccination regimen against pneumococcal infection in patients with chronic obstructive pulmonary disease (COPD) with consideration of changes in microbiological and clinical parameters.Subjects and Methods. 115 patients with COPD were randomized into 4 pneumococcal vaccination groups, they were examined and followed up for 4 years; 112 patients completed the study complying with the protocol. Detail medical history of all subjects was collected. To verify the diagnosis of COPD, all subjects underwent external respiratory function test and bronchodilator test (salbutamol, 400 μg) according to the standard method. The classic microbiological assessment was used in this study. The clinical effectiveness of vaccination was assessed. Statistical processing of the results was performed using StatPlus Pro 6.2.0.0 software (license number 2883).Results. Сonsecutive vaccination with pneumococcal conjugate and polysaccharide vaccines leads to decreased isolation rate of pneuniococcus from the sputum of CODP patients. The frequency of exacerbations, the need for antibiotic chemotherapy and hospitalizations also goes down.https://www.tibl-journal.com/jour/article/view/1550пневмококковая инфекцияхроническая обструктивная болезнь легкихвакцинацияпревенар-13пневмовакс-23конъюгированная полисахаридная вакцинаполисахаридная вакцинамикробиологический эффект |
| spellingShingle | M. P. Kostinov А. D. Protasov А. V. Zhetkov M. L. Shteyner Yu. V. Tezikov I. S. Lipatov The Effect of Different Regimens of Vaccination against Pneumococcal Infection on the Clinical Course of Chronic Obstructive Pulmonary Disease: Focus on Changes in Sputum Microorganism Population Туберкулез и болезни лёгких пневмококковая инфекция хроническая обструктивная болезнь легких вакцинация превенар-13 пневмовакс-23 конъюгированная полисахаридная вакцина полисахаридная вакцина микробиологический эффект |
| title | The Effect of Different Regimens of Vaccination against Pneumococcal Infection on the Clinical Course of Chronic Obstructive Pulmonary Disease: Focus on Changes in Sputum Microorganism Population |
| title_full | The Effect of Different Regimens of Vaccination against Pneumococcal Infection on the Clinical Course of Chronic Obstructive Pulmonary Disease: Focus on Changes in Sputum Microorganism Population |
| title_fullStr | The Effect of Different Regimens of Vaccination against Pneumococcal Infection on the Clinical Course of Chronic Obstructive Pulmonary Disease: Focus on Changes in Sputum Microorganism Population |
| title_full_unstemmed | The Effect of Different Regimens of Vaccination against Pneumococcal Infection on the Clinical Course of Chronic Obstructive Pulmonary Disease: Focus on Changes in Sputum Microorganism Population |
| title_short | The Effect of Different Regimens of Vaccination against Pneumococcal Infection on the Clinical Course of Chronic Obstructive Pulmonary Disease: Focus on Changes in Sputum Microorganism Population |
| title_sort | effect of different regimens of vaccination against pneumococcal infection on the clinical course of chronic obstructive pulmonary disease focus on changes in sputum microorganism population |
| topic | пневмококковая инфекция хроническая обструктивная болезнь легких вакцинация превенар-13 пневмовакс-23 конъюгированная полисахаридная вакцина полисахаридная вакцина микробиологический эффект |
| url | https://www.tibl-journal.com/jour/article/view/1550 |
| work_keys_str_mv | AT mpkostinov theeffectofdifferentregimensofvaccinationagainstpneumococcalinfectionontheclinicalcourseofchronicobstructivepulmonarydiseasefocusonchangesinsputummicroorganismpopulation AT adprotasov theeffectofdifferentregimensofvaccinationagainstpneumococcalinfectionontheclinicalcourseofchronicobstructivepulmonarydiseasefocusonchangesinsputummicroorganismpopulation AT avzhetkov theeffectofdifferentregimensofvaccinationagainstpneumococcalinfectionontheclinicalcourseofchronicobstructivepulmonarydiseasefocusonchangesinsputummicroorganismpopulation AT mlshteyner theeffectofdifferentregimensofvaccinationagainstpneumococcalinfectionontheclinicalcourseofchronicobstructivepulmonarydiseasefocusonchangesinsputummicroorganismpopulation AT yuvtezikov theeffectofdifferentregimensofvaccinationagainstpneumococcalinfectionontheclinicalcourseofchronicobstructivepulmonarydiseasefocusonchangesinsputummicroorganismpopulation AT islipatov theeffectofdifferentregimensofvaccinationagainstpneumococcalinfectionontheclinicalcourseofchronicobstructivepulmonarydiseasefocusonchangesinsputummicroorganismpopulation AT mpkostinov effectofdifferentregimensofvaccinationagainstpneumococcalinfectionontheclinicalcourseofchronicobstructivepulmonarydiseasefocusonchangesinsputummicroorganismpopulation AT adprotasov effectofdifferentregimensofvaccinationagainstpneumococcalinfectionontheclinicalcourseofchronicobstructivepulmonarydiseasefocusonchangesinsputummicroorganismpopulation AT avzhetkov effectofdifferentregimensofvaccinationagainstpneumococcalinfectionontheclinicalcourseofchronicobstructivepulmonarydiseasefocusonchangesinsputummicroorganismpopulation AT mlshteyner effectofdifferentregimensofvaccinationagainstpneumococcalinfectionontheclinicalcourseofchronicobstructivepulmonarydiseasefocusonchangesinsputummicroorganismpopulation AT yuvtezikov effectofdifferentregimensofvaccinationagainstpneumococcalinfectionontheclinicalcourseofchronicobstructivepulmonarydiseasefocusonchangesinsputummicroorganismpopulation AT islipatov effectofdifferentregimensofvaccinationagainstpneumococcalinfectionontheclinicalcourseofchronicobstructivepulmonarydiseasefocusonchangesinsputummicroorganismpopulation |