Photoactivated Chromophore for Keratitis-Corneal Collagen Cross-Linking (PACK-CXL) Improves Outcomes of Treatment-Resistant Infectious Keratitis
Rosario Gulias-Cañizo,1 Andres Benatti,2 Guillermo De Wit-Carter,3 Everardo Hernández-Quintela,3 Valeria Sánchez-Huerta3 1Universidad Anahuac Mexico, Huixquilucan, Estado de Mexico, Mexico; 2Cordoba Eye Clinic, Cornea and Refractive Surgery Department, Cordoba, Argen...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2020-12-01
|
| Series: | Clinical Ophthalmology |
| Subjects: | |
| Online Access: | https://www.dovepress.com/photoactivated-chromophore-for-keratitis-corneal-collagen-cross-linkin-peer-reviewed-article-OPTH |
| _version_ | 1830286569952509952 |
|---|---|
| author | Gulias-Cañizo R Benatti A De Wit-Carter G Hernández-Quintela E Sánchez-Huerta V |
| author_facet | Gulias-Cañizo R Benatti A De Wit-Carter G Hernández-Quintela E Sánchez-Huerta V |
| author_sort | Gulias-Cañizo R |
| collection | DOAJ |
| description | Rosario Gulias-Cañizo,1 Andres Benatti,2 Guillermo De Wit-Carter,3 Everardo Hernández-Quintela,3 Valeria Sánchez-Huerta3 1Universidad Anahuac Mexico, Huixquilucan, Estado de Mexico, Mexico; 2Cordoba Eye Clinic, Cornea and Refractive Surgery Department, Cordoba, Argentina; 3Asociación para Evitar la Ceguera en México, Hospital Dr. Luis Sanchez Bulnes, Cornea Department, Mexico City 04030, MexicoCorrespondence: Valeria Sánchez-HuertaAsociación para Evitar la Ceguera en México, Hospital Dr. Luis Sanchez Bulnes, Cornea Department, Vicente García Torres 46, San Lucas, Mexico City 04030, MexicoTel +5215525599999Fax +5215510841404Email valeriash@gmail.comPurpose: To investigate the efficacy of photoactivated chromophore corneal collagen cross-linking (PACK)-CXL in the management of treatment-resistant infectious keratitis.Design: Observational cohort study.Participants: Forty-two eyes from 41 patients with treatment-resistant infectious keratitis.Methods: Eyes underwent PACK-CXL treatment with the Dresden modified protocol in addition to standard antimicrobial therapy. The primary endpoint was the size of the corneal ulcer. Descriptive statistics, Wilcoxon rank test, McNemar test and Spearman correlation coefficient were used for statistical analysis, and p values lower than 0.05 were considered statistically significant.Results: Success rate at third postoperative month was of 90.5%. Statistical analyses showed a significant effect of (PACK)‑CXL with standard antimicrobial therapy to reduce corneal ulcer size (p=0.031).Conclusion: As adjuvant therapy to standard antimicrobial treatment, PACK-CXL improves the outcomes in patients with treatment-resistant corneal ulcers.Keywords: cross-linking, PACK-CXL, resistant keratitis |
| first_indexed | 2024-12-19T04:01:43Z |
| format | Article |
| id | doaj.art-f26aa246806647d9ac19a166469d8ae8 |
| institution | Directory Open Access Journal |
| issn | 1177-5483 |
| language | English |
| last_indexed | 2024-12-19T04:01:43Z |
| publishDate | 2020-12-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Clinical Ophthalmology |
| spelling | doaj.art-f26aa246806647d9ac19a166469d8ae82022-12-21T20:36:40ZengDove Medical PressClinical Ophthalmology1177-54832020-12-01Volume 144451445760517Photoactivated Chromophore for Keratitis-Corneal Collagen Cross-Linking (PACK-CXL) Improves Outcomes of Treatment-Resistant Infectious KeratitisGulias-Cañizo RBenatti ADe Wit-Carter GHernández-Quintela ESánchez-Huerta VRosario Gulias-Cañizo,1 Andres Benatti,2 Guillermo De Wit-Carter,3 Everardo Hernández-Quintela,3 Valeria Sánchez-Huerta3 1Universidad Anahuac Mexico, Huixquilucan, Estado de Mexico, Mexico; 2Cordoba Eye Clinic, Cornea and Refractive Surgery Department, Cordoba, Argentina; 3Asociación para Evitar la Ceguera en México, Hospital Dr. Luis Sanchez Bulnes, Cornea Department, Mexico City 04030, MexicoCorrespondence: Valeria Sánchez-HuertaAsociación para Evitar la Ceguera en México, Hospital Dr. Luis Sanchez Bulnes, Cornea Department, Vicente García Torres 46, San Lucas, Mexico City 04030, MexicoTel +5215525599999Fax +5215510841404Email valeriash@gmail.comPurpose: To investigate the efficacy of photoactivated chromophore corneal collagen cross-linking (PACK)-CXL in the management of treatment-resistant infectious keratitis.Design: Observational cohort study.Participants: Forty-two eyes from 41 patients with treatment-resistant infectious keratitis.Methods: Eyes underwent PACK-CXL treatment with the Dresden modified protocol in addition to standard antimicrobial therapy. The primary endpoint was the size of the corneal ulcer. Descriptive statistics, Wilcoxon rank test, McNemar test and Spearman correlation coefficient were used for statistical analysis, and p values lower than 0.05 were considered statistically significant.Results: Success rate at third postoperative month was of 90.5%. Statistical analyses showed a significant effect of (PACK)‑CXL with standard antimicrobial therapy to reduce corneal ulcer size (p=0.031).Conclusion: As adjuvant therapy to standard antimicrobial treatment, PACK-CXL improves the outcomes in patients with treatment-resistant corneal ulcers.Keywords: cross-linking, PACK-CXL, resistant keratitishttps://www.dovepress.com/photoactivated-chromophore-for-keratitis-corneal-collagen-cross-linkin-peer-reviewed-article-OPTHcross-linkingpack-cxlresistant keratitis |
| spellingShingle | Gulias-Cañizo R Benatti A De Wit-Carter G Hernández-Quintela E Sánchez-Huerta V Photoactivated Chromophore for Keratitis-Corneal Collagen Cross-Linking (PACK-CXL) Improves Outcomes of Treatment-Resistant Infectious Keratitis Clinical Ophthalmology cross-linking pack-cxl resistant keratitis |
| title | Photoactivated Chromophore for Keratitis-Corneal Collagen Cross-Linking (PACK-CXL) Improves Outcomes of Treatment-Resistant Infectious Keratitis |
| title_full | Photoactivated Chromophore for Keratitis-Corneal Collagen Cross-Linking (PACK-CXL) Improves Outcomes of Treatment-Resistant Infectious Keratitis |
| title_fullStr | Photoactivated Chromophore for Keratitis-Corneal Collagen Cross-Linking (PACK-CXL) Improves Outcomes of Treatment-Resistant Infectious Keratitis |
| title_full_unstemmed | Photoactivated Chromophore for Keratitis-Corneal Collagen Cross-Linking (PACK-CXL) Improves Outcomes of Treatment-Resistant Infectious Keratitis |
| title_short | Photoactivated Chromophore for Keratitis-Corneal Collagen Cross-Linking (PACK-CXL) Improves Outcomes of Treatment-Resistant Infectious Keratitis |
| title_sort | photoactivated chromophore for keratitis corneal collagen cross linking pack cxl improves outcomes of treatment resistant infectious keratitis |
| topic | cross-linking pack-cxl resistant keratitis |
| url | https://www.dovepress.com/photoactivated-chromophore-for-keratitis-corneal-collagen-cross-linkin-peer-reviewed-article-OPTH |
| work_keys_str_mv | AT guliascanizor photoactivatedchromophoreforkeratitiscornealcollagencrosslinkingpackcxlimprovesoutcomesoftreatmentresistantinfectiouskeratitis AT benattia photoactivatedchromophoreforkeratitiscornealcollagencrosslinkingpackcxlimprovesoutcomesoftreatmentresistantinfectiouskeratitis AT dewitcarterg photoactivatedchromophoreforkeratitiscornealcollagencrosslinkingpackcxlimprovesoutcomesoftreatmentresistantinfectiouskeratitis AT hernandezquintelae photoactivatedchromophoreforkeratitiscornealcollagencrosslinkingpackcxlimprovesoutcomesoftreatmentresistantinfectiouskeratitis AT sanchezhuertav photoactivatedchromophoreforkeratitiscornealcollagencrosslinkingpackcxlimprovesoutcomesoftreatmentresistantinfectiouskeratitis |