Altered Endoplasmic Reticulum Calcium Pump Expression during Breast Tumorigenesis
Endoplasmic reticulum calcium homeostasis is involved in several essential cell functions including cell proliferation, protein synthesis, stress responses or secretion. Calcium uptake into the endoplasmic reticulum is performed by Sarco/Endoplasmic Reticulum Calcium ATPases (SERCA enzymes). In orde...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2011-01-01
|
| Series: | Breast Cancer: Basic and Clinical Research |
| Online Access: | https://doi.org/10.4137/BCBCR.S7481 |
| _version_ | 1819154283404197888 |
|---|---|
| author | Béla Papp Jean-Philippe Brouland |
| author_facet | Béla Papp Jean-Philippe Brouland |
| author_sort | Béla Papp |
| collection | DOAJ |
| description | Endoplasmic reticulum calcium homeostasis is involved in several essential cell functions including cell proliferation, protein synthesis, stress responses or secretion. Calcium uptake into the endoplasmic reticulum is performed by Sarco/Endoplasmic Reticulum Calcium ATPases (SERCA enzymes). In order to study endoplasmic reticulum calcium homeostasis in situ in mammary tissue, in this work SERCA3 expression was investigated in normal breast and in its benign and malignant lesions in function of the cell type, degree of malignancy, and histological and molecular parameters of the tumors. Our data indicate, that although normal breast acinar epithelial cells express SERCA3 abundantly, its expression is strongly decreased already in very early non-malignant epithelial lesions such as adenosis, and remains low in lobular carcinomas. Whereas normal duct epithelium expresses significant amounts of SERCA3, its expression is decreased in several benign ductal lesions, as well as in ductal adenocarcinoma. The loss of SERCA3 expression is correlated with Elston-Ellis grade, negative hormone receptor expression or triple negative status in ductal carcinomas. The concordance between decreased SERCA3 expression and several histological, as well as molecular markers of ductal carcinogenesis indicates that endoplasmic reticulum calcium homeostasis is remodeled during tumorigenesis in the breast epithelium. |
| first_indexed | 2024-12-22T15:18:37Z |
| format | Article |
| id | doaj.art-f26b398e265a41d9bcb5ba2924c2dd0c |
| institution | Directory Open Access Journal |
| issn | 1178-2234 |
| language | English |
| last_indexed | 2024-12-22T15:18:37Z |
| publishDate | 2011-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Breast Cancer: Basic and Clinical Research |
| spelling | doaj.art-f26b398e265a41d9bcb5ba2924c2dd0c2022-12-21T18:21:41ZengSAGE PublishingBreast Cancer: Basic and Clinical Research1178-22342011-01-01510.4137/BCBCR.S7481Altered Endoplasmic Reticulum Calcium Pump Expression during Breast TumorigenesisBéla Papp0Jean-Philippe Brouland1Institut National de la Santé et de la Recherche Médicale, Inserm UMR-S 940, Institut Universitaire d'Hématologie, 16, rue de la Grange aux Belles, 75010 Paris, Université Paris Diderot, Sorbonne Paris Cité.Service d'Anatomie et Cytologie Pathologiques, Hôpital Lariboisière, 2, rue Ambroise Paré, 75010 Paris, Université Paris Diderot, Sorbonne Paris Cité, APHP, France.Endoplasmic reticulum calcium homeostasis is involved in several essential cell functions including cell proliferation, protein synthesis, stress responses or secretion. Calcium uptake into the endoplasmic reticulum is performed by Sarco/Endoplasmic Reticulum Calcium ATPases (SERCA enzymes). In order to study endoplasmic reticulum calcium homeostasis in situ in mammary tissue, in this work SERCA3 expression was investigated in normal breast and in its benign and malignant lesions in function of the cell type, degree of malignancy, and histological and molecular parameters of the tumors. Our data indicate, that although normal breast acinar epithelial cells express SERCA3 abundantly, its expression is strongly decreased already in very early non-malignant epithelial lesions such as adenosis, and remains low in lobular carcinomas. Whereas normal duct epithelium expresses significant amounts of SERCA3, its expression is decreased in several benign ductal lesions, as well as in ductal adenocarcinoma. The loss of SERCA3 expression is correlated with Elston-Ellis grade, negative hormone receptor expression or triple negative status in ductal carcinomas. The concordance between decreased SERCA3 expression and several histological, as well as molecular markers of ductal carcinogenesis indicates that endoplasmic reticulum calcium homeostasis is remodeled during tumorigenesis in the breast epithelium.https://doi.org/10.4137/BCBCR.S7481 |
| spellingShingle | Béla Papp Jean-Philippe Brouland Altered Endoplasmic Reticulum Calcium Pump Expression during Breast Tumorigenesis Breast Cancer: Basic and Clinical Research |
| title | Altered Endoplasmic Reticulum Calcium Pump Expression during Breast Tumorigenesis |
| title_full | Altered Endoplasmic Reticulum Calcium Pump Expression during Breast Tumorigenesis |
| title_fullStr | Altered Endoplasmic Reticulum Calcium Pump Expression during Breast Tumorigenesis |
| title_full_unstemmed | Altered Endoplasmic Reticulum Calcium Pump Expression during Breast Tumorigenesis |
| title_short | Altered Endoplasmic Reticulum Calcium Pump Expression during Breast Tumorigenesis |
| title_sort | altered endoplasmic reticulum calcium pump expression during breast tumorigenesis |
| url | https://doi.org/10.4137/BCBCR.S7481 |
| work_keys_str_mv | AT belapapp alteredendoplasmicreticulumcalciumpumpexpressionduringbreasttumorigenesis AT jeanphilippebrouland alteredendoplasmicreticulumcalciumpumpexpressionduringbreasttumorigenesis |