| Summary: | The aims of this work were to study bioactive compounds, antioxidant and alpha glucosidase inhibitory activites of Tot Mu Tot Ma (Paederia linearis) in crude extracts of root, stem and leaf. The maceration method was used with ethanol as solvent. Bioactive compounds in the phytochemical screening study, were flavonoid, terpenoid, saponin, steroid and cardiac glycosides. Total phenolic and flavonoid content were measured in all extracts. Investigation of antioxidant activites used 2,2-diphenyl-1-picrylhydrazyl (DPPH) and ferric reducing antioxidant power (FRAP). In vitro α-glucosidase
inhibitory assays were performed in this study. The results showed that the ethanolic leaf extracts had the highest total phenolic content (174.42±2.07 mgGAE.g-¹) and flavonoid content (41.32±1.94 mgQE.g-1). Antioxidant activity in leaf extracts was high in both testing methods, i.e. DPPH method (40.73±6.68%) and FRAP method (21.35±5.80 mMFe.g-1). In addition, the leaf of P. linearis revealed highest alpha glucosidase inhibitory activity at 93.04±1.63%. The results suggest that the leaf extract of P. linearis may be used to treat type 2 diabetes.
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